Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higB-toxA/Tad-HTH_37
Location 417165..417793 Replicon chromosome
Accession NZ_CP025582
Organism Lacticaseibacillus paracasei strain HD1.7

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag CWS34_RS02125 Protein ID WP_003583266.1
Coordinates 417425..417793 (-) Length 123 a.a.

Antitoxin (Protein)


Gene name toxA Uniprot ID -
Locus tag CWS34_RS02120 Protein ID WP_003583264.1
Coordinates 417165..417425 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CWS34_RS02095 413056..413799 + 744 WP_003563368.1 SDR family oxidoreductase -
CWS34_RS02100 413912..414538 + 627 WP_003583257.1 flavodoxin -
CWS34_RS02105 414789..415292 + 504 WP_003583259.1 TetR/AcrR family transcriptional regulator -
CWS34_RS02110 415297..416358 + 1062 WP_003583262.1 ABC transporter permease -
CWS34_RS02115 416363..417052 + 690 WP_003583263.1 ABC transporter ATP-binding protein -
CWS34_RS02120 417165..417425 - 261 WP_003583264.1 helix-turn-helix transcriptional regulator Antitoxin
CWS34_RS02125 417425..417793 - 369 WP_003583266.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CWS34_RS02130 418083..419453 - 1371 WP_003573580.1 FAD-dependent oxidoreductase -
CWS34_RS02135 419817..420635 - 819 WP_101512325.1 Cof-type HAD-IIB family hydrolase -
CWS34_RS02140 420954..421223 - 270 WP_003563382.1 type II toxin-antitoxin system YafQ family toxin -
CWS34_RS02145 421464..422471 + 1008 WP_003563383.1 LacI family DNA-binding transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(34-112)

Antitoxin

Cro/C1-type helix-turn-helix domain

(28-79)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 14939.01 Da        Isoelectric Point: 8.3986

>T90623 WP_003583266.1 NZ_CP025582:c417793-417425 [Lacticaseibacillus paracasei]
MYKIDFYEDRDGYSEIEDFLDQLRHSHQKNNVSLLNKITKELYMLQNLGPRLREPHAKFLKGYAYPIMELRPMPERIFYA
AWQKDHFVLLHHYTKKTNKTDHREILRAQSNLEDWLSRKEEN

Download         Length: 369 bp

>T90623 NZ_CP025582:c417793-417425 [Lacticaseibacillus paracasei]
ATGTATAAAATTGACTTCTATGAGGATCGCGATGGCTACTCTGAGATCGAAGACTTTCTTGATCAGTTACGCCATAGTCA
TCAAAAAAATAATGTGAGCCTTTTAAACAAAATCACAAAGGAACTCTACATGCTGCAAAATCTTGGTCCGCGCTTACGTG
AACCTCACGCGAAGTTTCTGAAGGGATATGCTTATCCGATCATGGAATTGCGTCCCATGCCAGAAAGAATCTTTTATGCT
GCATGGCAAAAGGATCATTTCGTTTTGCTTCATCACTACACCAAGAAAACAAACAAAACTGATCACAGAGAAATTTTACG
GGCACAGTCTAACCTCGAAGATTGGCTCTCTAGAAAGGAAGAAAATTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9828.45 Da        Isoelectric Point: 10.2439

>AT90623 WP_003583264.1 NZ_CP025582:c417425-417165 [Lacticaseibacillus paracasei]
MTTWEDFSQKLKKDNPEKLAIIKTLADLESERIKQGISQKDFAEKIGMKQPQLAKIERLDSLPTLATLNRYARGLGKEIR
LSIVTQ

Download         Length: 261 bp

>AT90623 NZ_CP025582:c417425-417165 [Lacticaseibacillus paracasei]
ATGACGACATGGGAAGACTTCAGTCAGAAACTGAAGAAGGACAATCCAGAAAAGTTGGCAATCATCAAAACCTTGGCCGA
TTTAGAAAGTGAACGAATCAAGCAAGGAATCTCTCAAAAGGACTTTGCAGAAAAAATTGGTATGAAACAGCCGCAACTAG
CAAAGATTGAGCGCTTAGACTCTCTTCCGACTCTGGCAACACTCAATCGATACGCGAGAGGGCTTGGAAAAGAAATTCGT
TTATCAATTGTTACTCAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References