Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2543319..2544150 Replicon chromosome
Accession NZ_CP025573
Organism Escherichia coli strain E-1246

Toxin (Protein)


Gene name yeeV Uniprot ID S1P968
Locus tag CY655_RS12925 Protein ID WP_000854814.1
Coordinates 2543776..2544150 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID B3Y195
Locus tag CY655_RS12920 Protein ID WP_001285585.1
Coordinates 2543319..2543687 (+) Length 123 a.a.

Genomic Context


CY655_RS12895CY655_RS12900CY655_RS12905CY655_RS12910CY655_RS12915CY655_RS12920CY655_RS12925CY655_RS12930CY655_RS12935CY655_RS12945CY655_RS12885CY655_RS12890CY655_RS12940CY655_RS12950CY655_RS12955CY655_RS12960CY655_RS12965
Location: 2540888..2541574 (687 bp)
Type: Others
Protein ID: Protein_2448
Location: 2541561..2541908 (348 bp)
Type: Others
Protein ID: Protein_2449
Location: 2541990..2542469 (480 bp)
Type: Others
Protein ID: WP_000860074.1
Location: 2542485..2542961 (477 bp)
Type: Others
Protein ID: WP_001186726.1
Location: 2543024..2543245 (222 bp)
Type: Others
Protein ID: WP_000692300.1
Location: 2543319..2543687 (369 bp)
Type: Antitoxin
Protein ID: WP_001285585.1
Location: 2543776..2544150 (375 bp)
Type: Toxin
Protein ID: WP_000854814.1
Location: 2544147..2544341 (195 bp)
Type: Others
Protein ID: WP_000988600.1
Location: 2544354..2544467 (114 bp)
Type: Others
Protein ID: WP_032154230.1
Location: 2544956..2545138 (183 bp)
Type: Others
Protein ID: WP_001016348.1
Location: 2538390..2539136 (747 bp)
Type: Others
Protein ID: WP_001016257.1
Location: 2539151..2540692 (1542 bp)
Type: Others
Protein ID: WP_001298859.1
Location: 2544756..2544902 (147 bp)
Type: Others
Protein ID: Protein_2457
Location: 2545239..2545568 (330 bp)
Type: Others
Protein ID: WP_000450409.1
Location: 2545740..2546798 (1059 bp)
Type: Others
Protein ID: WP_001200884.1
Location: 2546996..2547469 (474 bp)
Type: Others
Protein ID: WP_001105389.1
Location: 2547588..2548754 (1167 bp)
Type: Others
Protein ID: WP_000830160.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
CY655_RS128852538390..2539136-747WP_001016257.1IS21-like element ISEc12 family helper ATPase IstB-
CY655_RS128902539151..2540692-1542WP_001298859.1IS21-like element ISEc12 family transposase-
CY655_RS128952540888..2541574+687Protein_2448AIDA repeat-containing protein-
CY655_RS129002541561..2541908+348Protein_2449DUF932 domain-containing protein-
CY655_RS129052541990..2542469+480WP_000860074.1antirestriction protein-
CY655_RS129102542485..2542961+477WP_001186726.1RadC family protein-
CY655_RS129152543024..2543245+222WP_000692300.1DUF987 domain-containing protein-
CY655_RS129202543319..2543687+369WP_001285585.1type IV toxin-antitoxin system toxin CbtAAntitoxin
CY655_RS129252543776..2544150+375WP_000854814.1type IV toxin-antitoxin system toxin CbtAToxin
CY655_RS129302544147..2544341+195WP_000988600.1hypothetical protein-
CY655_RS129352544354..2544467+114WP_032154230.1DUF957 domain-containing protein-
CY655_RS129402544756..2544902-147Protein_2457transposase domain-containing protein-
CY655_RS129452544956..2545138+183WP_001016348.1hypothetical protein-
CY655_RS129502545239..2545568-330WP_000450409.1DUF496 family protein-
CY655_RS129552545740..2546798-1059WP_001200884.1FUSC family protein-
CY655_RS129602546996..2547469-474WP_001105389.1DNA gyrase inhibitor SbmC-
CY655_RS129652547588..2548754-1167WP_000830160.1serine-type D-Ala-D-Ala carboxypeptidase DacD-

Associated MGEs


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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-112)

Antitoxin

(18-117)


Sequences


Toxin        


Download         Length: 125 a.a.        Molecular weight: 13898.94 Da        Isoelectric Point: 7.8522

>T90579 WP_000854814.1 NZ_CP025573:2543776-2544150 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T90579 NZ_CP025573:2543776-2544150 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCTTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13593.48 Da        Isoelectric Point: 6.3139

>AT90579 WP_001285585.1 NZ_CP025573:2543319-2543687 [Escherichia coli]
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT90579 NZ_CP025573:2543319-2543687 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Similar Proteins


Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures


Toxin

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Source
ID
Structure
AlphaFold DBA0A829FY50


Antitoxin

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Source
ID
Structure
AlphaFold DBA0A7U9LW60

References