Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
Location | 2543319..2544150 | Replicon | chromosome |
Accession | NZ_CP025573 | ||
Organism | Escherichia coli strain E-1246 |
Toxin (Protein)
Gene name | yeeV | Uniprot ID | S1P968 |
Locus tag | CY655_RS12925 | Protein ID | WP_000854814.1 |
Coordinates | 2543776..2544150 (+) | Length | 125 a.a. |
Antitoxin (Protein)
Gene name | yeeU | Uniprot ID | B3Y195 |
Locus tag | CY655_RS12920 | Protein ID | WP_001285585.1 |
Coordinates | 2543319..2543687 (+) | Length | 123 a.a. |
Genomic Context
Location: 2540888..2541574 (687 bp)
Type: Others
Protein ID: Protein_2448
Type: Others
Protein ID: Protein_2448
Location: 2541561..2541908 (348 bp)
Type: Others
Protein ID: Protein_2449
Type: Others
Protein ID: Protein_2449
Location: 2541990..2542469 (480 bp)
Type: Others
Protein ID: WP_000860074.1
Type: Others
Protein ID: WP_000860074.1
Location: 2542485..2542961 (477 bp)
Type: Others
Protein ID: WP_001186726.1
Type: Others
Protein ID: WP_001186726.1
Location: 2543024..2543245 (222 bp)
Type: Others
Protein ID: WP_000692300.1
Type: Others
Protein ID: WP_000692300.1
Location: 2543319..2543687 (369 bp)
Type: Antitoxin
Protein ID: WP_001285585.1
Type: Antitoxin
Protein ID: WP_001285585.1
Location: 2543776..2544150 (375 bp)
Type: Toxin
Protein ID: WP_000854814.1
Type: Toxin
Protein ID: WP_000854814.1
Location: 2544147..2544341 (195 bp)
Type: Others
Protein ID: WP_000988600.1
Type: Others
Protein ID: WP_000988600.1
Location: 2544354..2544467 (114 bp)
Type: Others
Protein ID: WP_032154230.1
Type: Others
Protein ID: WP_032154230.1
Location: 2544956..2545138 (183 bp)
Type: Others
Protein ID: WP_001016348.1
Type: Others
Protein ID: WP_001016348.1
Location: 2538390..2539136 (747 bp)
Type: Others
Protein ID: WP_001016257.1
Type: Others
Protein ID: WP_001016257.1
Location: 2539151..2540692 (1542 bp)
Type: Others
Protein ID: WP_001298859.1
Type: Others
Protein ID: WP_001298859.1
Location: 2544756..2544902 (147 bp)
Type: Others
Protein ID: Protein_2457
Type: Others
Protein ID: Protein_2457
Location: 2545239..2545568 (330 bp)
Type: Others
Protein ID: WP_000450409.1
Type: Others
Protein ID: WP_000450409.1
Location: 2545740..2546798 (1059 bp)
Type: Others
Protein ID: WP_001200884.1
Type: Others
Protein ID: WP_001200884.1
Location: 2546996..2547469 (474 bp)
Type: Others
Protein ID: WP_001105389.1
Type: Others
Protein ID: WP_001105389.1
Location: 2547588..2548754 (1167 bp)
Type: Others
Protein ID: WP_000830160.1
Type: Others
Protein ID: WP_000830160.1
Loading, please wait
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
CY655_RS12885 | 2538390..2539136 | - | 747 | WP_001016257.1 | IS21-like element ISEc12 family helper ATPase IstB | - |
CY655_RS12890 | 2539151..2540692 | - | 1542 | WP_001298859.1 | IS21-like element ISEc12 family transposase | - |
CY655_RS12895 | 2540888..2541574 | + | 687 | Protein_2448 | AIDA repeat-containing protein | - |
CY655_RS12900 | 2541561..2541908 | + | 348 | Protein_2449 | DUF932 domain-containing protein | - |
CY655_RS12905 | 2541990..2542469 | + | 480 | WP_000860074.1 | antirestriction protein | - |
CY655_RS12910 | 2542485..2542961 | + | 477 | WP_001186726.1 | RadC family protein | - |
CY655_RS12915 | 2543024..2543245 | + | 222 | WP_000692300.1 | DUF987 domain-containing protein | - |
CY655_RS12920 | 2543319..2543687 | + | 369 | WP_001285585.1 | type IV toxin-antitoxin system toxin CbtA | Antitoxin |
CY655_RS12925 | 2543776..2544150 | + | 375 | WP_000854814.1 | type IV toxin-antitoxin system toxin CbtA | Toxin |
CY655_RS12930 | 2544147..2544341 | + | 195 | WP_000988600.1 | hypothetical protein | - |
CY655_RS12935 | 2544354..2544467 | + | 114 | WP_032154230.1 | DUF957 domain-containing protein | - |
CY655_RS12940 | 2544756..2544902 | - | 147 | Protein_2457 | transposase domain-containing protein | - |
CY655_RS12945 | 2544956..2545138 | + | 183 | WP_001016348.1 | hypothetical protein | - |
CY655_RS12950 | 2545239..2545568 | - | 330 | WP_000450409.1 | DUF496 family protein | - |
CY655_RS12955 | 2545740..2546798 | - | 1059 | WP_001200884.1 | FUSC family protein | - |
CY655_RS12960 | 2546996..2547469 | - | 474 | WP_001105389.1 | DNA gyrase inhibitor SbmC | - |
CY655_RS12965 | 2547588..2548754 | - | 1167 | WP_000830160.1 | serine-type D-Ala-D-Ala carboxypeptidase DacD | - |
Associated MGEs
Loading, please wait
MGE detail | Similar MGEs | Relative position | MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
No matching records found |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 125 a.a. Molecular weight: 13898.94 Da Isoelectric Point: 7.8522
>T90579 WP_000854814.1 NZ_CP025573:2543776-2544150 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK
Download Length: 375 bp
>T90579 NZ_CP025573:2543776-2544150 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCTTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCTTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA
Antitoxin
Download Length: 123 a.a. Molecular weight: 13593.48 Da Isoelectric Point: 6.3139
>AT90579 WP_001285585.1 NZ_CP025573:2543319-2543687 [Escherichia coli]
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYLAVYPTPEMKN
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYLAVYPTPEMKN
Download Length: 369 bp
>AT90579 NZ_CP025573:2543319-2543687 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA
GTGTCAGACACACTCCCCGGGACAACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA
Structures
Toxin
Loading, please wait
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A829FY50 |
Antitoxin
Loading, please wait
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A7U9LW60 |