90579

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2543319..2544150 Replicon chromosome
Accession NZ_CP025573
Organism Escherichia coli strain E-1246

Toxin (Protein)


Gene name yeeV Uniprot ID S1P968
Locus tag CY655_RS12925 Protein ID WP_000854814.1
Coordinates 2543776..2544150 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID B3Y195
Locus tag CY655_RS12920 Protein ID WP_001285585.1
Coordinates 2543319..2543687 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CY655_RS12885 2538390..2539136 - 747 WP_001016257.1 IS21-like element ISEc12 family helper ATPase IstB -
CY655_RS12890 2539151..2540692 - 1542 WP_001298859.1 IS21-like element ISEc12 family transposase -
CY655_RS12895 2540888..2541574 + 687 Protein_2448 AIDA repeat-containing protein -
CY655_RS12900 2541561..2541908 + 348 Protein_2449 DUF932 domain-containing protein -
CY655_RS12905 2541990..2542469 + 480 WP_000860074.1 antirestriction protein -
CY655_RS12910 2542485..2542961 + 477 WP_001186726.1 RadC family protein -
CY655_RS12915 2543024..2543245 + 222 WP_000692300.1 DUF987 domain-containing protein -
CY655_RS12920 2543319..2543687 + 369 WP_001285585.1 type IV toxin-antitoxin system toxin CbtA Antitoxin
CY655_RS12925 2543776..2544150 + 375 WP_000854814.1 type IV toxin-antitoxin system toxin CbtA Toxin
CY655_RS12930 2544147..2544341 + 195 WP_000988600.1 hypothetical protein -
CY655_RS12935 2544354..2544467 + 114 WP_032154230.1 DUF957 domain-containing protein -
CY655_RS12940 2544756..2544902 - 147 Protein_2457 transposase domain-containing protein -
CY655_RS12945 2544956..2545138 + 183 WP_001016348.1 hypothetical protein -
CY655_RS12950 2545239..2545568 - 330 WP_000450409.1 DUF496 family protein -
CY655_RS12955 2545740..2546798 - 1059 WP_001200884.1 FUSC family protein -
CY655_RS12960 2546996..2547469 - 474 WP_001105389.1 DNA gyrase inhibitor SbmC -
CY655_RS12965 2547588..2548754 - 1167 WP_000830160.1 serine-type D-Ala-D-Ala carboxypeptidase DacD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13898.94 Da        Isoelectric Point: 7.8522

>T90579 WP_000854814.1 NZ_CP025573:2543776-2544150 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T90579 NZ_CP025573:2543776-2544150 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCTTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13593.48 Da        Isoelectric Point: 6.3139

>AT90579 WP_001285585.1 NZ_CP025573:2543319-2543687 [Escherichia coli]
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT90579 NZ_CP025573:2543319-2543687 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FY50

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LW60

References