Detailed information of TA system TA090556

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ccdAB/CcdA(antitoxin)
• Location: 46126..46651
• Replicon: plasmid p1PIR00532
• Accession: NZ_CP025557
• Organism: Salmonella enterica subsp. enterica serovar Enteritidis strain PIR00532

Toxin (Protein)

• Gene name: ccdB
• Uniprot ID: I3W3D5
• Locus tag: C0Z07_RS00315
• Protein ID: WP_001159863.1
• Coordinates: 46346..46651 (+)
• Length: 102 a.a.

Antitoxin (Protein)

• Gene name: ccdA
• Uniprot ID: M7S5D0
• Locus tag: C0Z07_RS00310
• Protein ID: WP_000813641.1
• Coordinates: 46126..46344 (+)
• Length: 73 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C0Z07_RS00280	41739..42125	+	387	WP_000751876.1	YgiW/YdeI family stress tolerance OB fold protein	-
C0Z07_RS00285	42178..42339	+	162	WP_015059604.1	hypothetical protein	-
C0Z07_RS00290	42666..43655	-	990	WP_000461382.1	RepB family plasmid replication initiator protein	-
C0Z07_RS00295	44150..44445	-	296	Protein_57	cytoplasmic protein	-
C0Z07_RS24660	44457..44885	+	429	Protein_58	hypothetical protein	-
C0Z07_RS00305	44929..45450	-	522	WP_077681952.1	hypothetical protein	-
C0Z07_RS00310	46126..46344	+	219	WP_000813641.1	type II toxin-antitoxin system antitoxin CcdA	Antitoxin
C0Z07_RS00315	46346..46651	+	306	WP_001159863.1	type II toxin-antitoxin system toxin CcdB	Toxin
C0Z07_RS00320	46653..46943	+	291	WP_001266176.1	hypothetical protein	-
C0Z07_RS00325	46940..47461	+	522	WP_000198608.1	hypothetical protein	-
C0Z07_RS00330	47496..48278	+	783	WP_000082169.1	site-specific integrase	-
C0Z07_RS00335	48287..49000	+	714	WP_000545756.1	EAL domain-containing protein	-
C0Z07_RS00340	49004..49513	+	510	WP_001541544.1	CaiF/GrlA family transcriptional regulator	-
C0Z07_RS00345	49507..49992	+	486	WP_000905606.1	membrane protein	-
C0Z07_RS24540	50269..50556	-	288	WP_071530243.1	hypothetical protein	-
C0Z07_RS00350	50712..51272	+	561	WP_000900095.1	inverse autotransporter beta domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..59373	59373

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-83)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-69)

Sequences

Toxin

Protein

• Length: 102 a.a.
• Molecular weight: 13091.77 Da
• Isoelectric Point: 12.8043

>T90556 WP_001159863.1 NZ_CP025557:46346-46651 [Salmonella enterica subsp. enterica serovar Enteritidis]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKK

Nucleotide

• Length: 306 bp

>T90556 NZ_CP025557:46346-46651 [Salmonella enterica subsp. enterica serovar Enteritidis]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Antitoxin

Protein

• Length: 73 a.a.
• Molecular weight: 9374.72 Da
• Isoelectric Point: 12.6573

>AT90556 WP_000813641.1 NZ_CP025557:46126-46344 [Salmonella enterica subsp. enterica serovar Enteritidis]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK

Nucleotide

• Length: 219 bp

>AT90556 NZ_CP025557:46126-46344 [Salmonella enterica subsp. enterica serovar Enteritidis]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Structures

Toxin

• AlphaFold DB: I3W3D5

Antitoxin

• AlphaFold DB: A0A656ICA6