Detailed information of TA system TA090555

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ccdAB/CcdA(antitoxin)
• Location: 61315..61840
• Replicon: plasmid pPIR00538
• Accession: NZ_CP025556
• Organism: Salmonella enterica subsp. enterica serovar Typhimurium strain PIR00538

Toxin (Protein)

• Gene name: ccdB
• Uniprot ID: I3W3D5
• Locus tag: C0Z08_RS25420
• Protein ID: WP_001159863.1
• Coordinates: 61535..61840 (+)
• Length: 102 a.a.

Antitoxin (Protein)

• Gene name: ccdA
• Uniprot ID: M7S5D0
• Locus tag: C0Z08_RS25415
• Protein ID: WP_000813641.1
• Coordinates: 61315..61533 (+)
• Length: 73 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C0Z08_RS25385	56602..56983	+	382	Protein_67	YgiW/YdeI family stress tolerance OB fold protein	-
C0Z08_RS25390	57152..57596	+	445	Protein_68	site-specific integrase	-
C0Z08_RS25395	57855..58844	-	990	WP_001527061.1	RepB family plasmid replication initiator protein	-
C0Z08_RS25400	59338..59634	-	297	WP_001687482.1	hypothetical protein	-
C0Z08_RS25410	60118..60639	-	522	WP_010999942.1	hypothetical protein	-
C0Z08_RS25415	61315..61533	+	219	WP_000813641.1	type II toxin-antitoxin system antitoxin CcdA	Antitoxin
C0Z08_RS25420	61535..61840	+	306	WP_001159863.1	type II toxin-antitoxin system toxin CcdB	Toxin
C0Z08_RS25425	61842..62132	+	291	WP_001266176.1	hypothetical protein	-
C0Z08_RS25430	62129..62650	+	522	WP_000198608.1	hypothetical protein	-
C0Z08_RS25435	62685..63467	+	783	WP_000082169.1	site-specific integrase	-
C0Z08_RS25440	63476..64189	+	714	Protein_77	EAL domain-containing protein	-
C0Z08_RS25450	64193..64702	+	510	WP_001541544.1	CaiF/GrlA family transcriptional regulator	-
C0Z08_RS25455	64696..65181	+	486	WP_000905606.1	membrane protein	-
C0Z08_RS25705	65458..65745	-	288	WP_071530243.1	hypothetical protein	-
C0Z08_RS25460	65901..66461	+	561	WP_000900095.1	inverse autotransporter beta domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..93832	93832

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (7-264)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (1-93)

Sequences

Toxin

Protein

• Length: 102 a.a.
• Molecular weight: 13091.77 Da
• Isoelectric Point: 12.8043

>T90555 WP_001159863.1 NZ_CP025556:61535-61840 [Salmonella enterica subsp. enterica serovar Typhimurium]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKK

Nucleotide

• Length: 306 bp

>T90555 NZ_CP025556:61535-61840 [Salmonella enterica subsp. enterica serovar Typhimurium]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Antitoxin

Protein

• Length: 73 a.a.
• Molecular weight: 9374.72 Da
• Isoelectric Point: 12.6573

>AT90555 WP_000813641.1 NZ_CP025556:61315-61533 [Salmonella enterica subsp. enterica serovar Typhimurium]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK

Nucleotide

• Length: 219 bp

>AT90555 NZ_CP025556:61315-61533 [Salmonella enterica subsp. enterica serovar Typhimurium]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Structures

Toxin

• AlphaFold DB: I3W3D5

Antitoxin

• AlphaFold DB: A0A656ICA6