Detailed information of TA system TA090553

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ccdAB/CcdA(antitoxin)
• Location: 15172..15697
• Replicon: plasmid pPIR00558
• Accession: NZ_CP025553
• Organism: Salmonella enterica subsp. enterica serovar Enteritidis strain ATCC BAA-708

Toxin (Protein)

• Gene name: ccdB
• Uniprot ID: I3W3D5
• Locus tag: C0Z09_RS00100
• Protein ID: WP_001159863.1
• Coordinates: 15172..15477 (-)
• Length: 102 a.a.

Antitoxin (Protein)

• Gene name: ccdA
• Uniprot ID: M7S5D0
• Locus tag: C0Z09_RS00105
• Protein ID: WP_000813641.1
• Coordinates: 15479..15697 (-)
• Length: 73 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C0Z09_RS00060	10552..11111	-	560	Protein_11	inverse autotransporter beta domain-containing protein	-
C0Z09_RS24405	11267..11554	+	288	WP_071530243.1	hypothetical protein	-
C0Z09_RS00070	11831..12316	-	486	WP_000905606.1	membrane protein	-
C0Z09_RS00075	12310..12819	-	510	WP_001541544.1	CaiF/GrlA family transcriptional regulator	-
C0Z09_RS00080	12823..13536	-	714	WP_000545756.1	EAL domain-containing protein	-
C0Z09_RS00085	13545..14327	-	783	WP_000082169.1	site-specific integrase	-
C0Z09_RS00090	14362..14883	-	522	WP_000198608.1	hypothetical protein	-
C0Z09_RS00095	14880..15170	-	291	WP_001266176.1	hypothetical protein	-
C0Z09_RS00100	15172..15477	-	306	WP_001159863.1	type II toxin-antitoxin system toxin CcdB	Toxin
C0Z09_RS00105	15479..15697	-	219	WP_000813641.1	type II toxin-antitoxin system antitoxin CcdA	Antitoxin
C0Z09_RS00110	16372..16893	+	522	WP_077681952.1	hypothetical protein	-
C0Z09_RS24410	16936..17364	-	429	Protein_22	hypothetical protein	-
C0Z09_RS00120	17376..17671	+	296	Protein_23	cytoplasmic protein	-
C0Z09_RS00125	18165..19154	+	990	WP_000461382.1	RepB family plasmid replication initiator protein	-
C0Z09_RS00130	19481..19642	-	162	WP_015059604.1	hypothetical protein	-
C0Z09_RS00135	19695..20081	-	387	WP_000751876.1	YgiW/YdeI family stress tolerance OB fold protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..59331	59331

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Fido domain (13-86)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-50)

Sequences

Toxin

Protein

• Length: 102 a.a.
• Molecular weight: 15030.03 Da
• Isoelectric Point: 5.5500

>T90553 WP_001159863.1 NZ_CP025553:c15477-15172 [Salmonella enterica subsp. enterica serovar Enteritidis]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFF

Nucleotide

• Length: 306 bp

>T90553 NZ_CP025553:c15477-15172 [Salmonella enterica subsp. enterica serovar Enteritidis]
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT

Antitoxin

Protein

• Length: 73 a.a.
• Molecular weight: 10761.91 Da
• Isoelectric Point: 5.5500

>AT90553 WP_000813641.1 NZ_CP025553:c15697-15479 [Salmonella enterica subsp. enterica serovar Enteritidis]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF

Nucleotide

• Length: 219 bp

>AT90553 NZ_CP025553:c15697-15479 [Salmonella enterica subsp. enterica serovar Enteritidis]
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT

Structures

Toxin

• AlphaFold DB: I3W3D5

Antitoxin

• AlphaFold DB: A0A656ICA6