Detailed information of TA system TA090551

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-Phd
• Location: 3423906..3424431
• Replicon: chromosome
• Accession: NZ_CP025551
• Organism: Streptomyces rimosus strain WT5260

Toxin (Protein)

• Gene name: relE
• Uniprot ID: L8EGB8
• Locus tag: CTZ40_RS14025
• Protein ID: WP_003987428.1
• Coordinates: 3424168..3424431 (+)
• Length: 88 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: L8ED57
• Locus tag: CTZ40_RS14020
• Protein ID: WP_003987429.1
• Coordinates: 3423906..3424175 (+)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CTZ40_RS13995	3418939..3419661	+	723	WP_030181983.1	PIG-L family deacetylase	-
CTZ40_RS14000	3419649..3420617	-	969	WP_003982326.1	alpha/beta hydrolase	-
CTZ40_RS14005	3420747..3421256	+	510	WP_003982327.1	hypothetical protein	-
CTZ40_RS14010	3421297..3421881	+	585	WP_003982328.1	Uma2 family endonuclease	-
CTZ40_RS14015	3421923..3423602	-	1680	WP_076611972.1	IS1182-like element ISSdi1 family transposase	-
CTZ40_RS14020	3423906..3424175	+	270	WP_003987429.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
CTZ40_RS14025	3424168..3424431	+	264	WP_003987428.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
CTZ40_RS14030	3424566..3425654	-	1089	WP_003987427.1	redox-regulated ATPase YchF	-
CTZ40_RS14035	3426197..3426904	+	708	WP_063604328.1	hypothetical protein	-
CTZ40_RS14040	3426870..3427742	-	873	WP_078586864.1	ROK family protein	-
CTZ40_RS14045	3427828..3428871	-	1044	WP_078586862.1	4-hydroxy-3-methylbut-2-enyl diphosphate reductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	3421923..3423602	1679

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-85)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (9-56)

Sequences

Toxin

Protein

• Length: 88 a.a.
• Molecular weight: 10084.54 Da
• Isoelectric Point: 8.5041

>T90551 WP_003987428.1 NZ_CP025551:3424168-3424431 [Streptomyces rimosus]
VSEYRTVFRPEAQTELRKVPRDMALRILAKLTELETDPLGFNTTALVSQPDRRRLRVGDYRLIYTIDNGELVVWVVHVGH
RSTVYDA

Nucleotide

• Length: 264 bp

>T90551 NZ_CP025551:3424168-3424431 [Streptomyces rimosus]
GTGAGTGAGTACCGCACCGTCTTCCGCCCCGAGGCTCAGACCGAACTCCGCAAGGTCCCGCGAGACATGGCTCTCCGCAT
TCTGGCGAAGCTGACCGAGTTGGAGACCGACCCGCTGGGGTTCAACACCACCGCCCTCGTCTCCCAGCCCGACCGCCGAC
GCCTACGAGTGGGTGACTACCGCCTGATCTACACGATCGACAACGGCGAGCTGGTGGTGTGGGTGGTACACGTCGGGCAT
CGCTCCACCGTCTACGACGCCTGA

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 10290.73 Da
• Isoelectric Point: 4.7473

>AT90551 WP_003987429.1 NZ_CP025551:3423906-3424175 [Streptomyces rimosus]
MTQPLPIESIRDVRAHLAEVVERADRDDVPTVITRRGKQVAAVVSIETLRKYQEWEEREINRIIDERMANPAPGIPLEDI
MRETLARSE

Nucleotide

• Length: 270 bp

>AT90551 NZ_CP025551:3423906-3424175 [Streptomyces rimosus]
ATGACGCAGCCACTGCCCATAGAGTCCATCCGCGATGTCCGGGCGCATCTGGCCGAGGTCGTTGAGCGAGCCGACCGGGA
CGACGTACCCACCGTGATCACCCGACGCGGCAAGCAGGTCGCCGCCGTCGTCTCCATCGAGACGCTGCGCAAGTACCAGG
AGTGGGAAGAGCGCGAGATCAACCGGATCATCGATGAGCGCATGGCCAACCCTGCACCCGGCATCCCGCTCGAGGACATC
ATGAGGGAGACGCTGGCACGCAGTGAGTGA

Structures

Toxin

• AlphaFold DB: L8EGB8

Antitoxin

• AlphaFold DB: L8ED57