Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 446368..447017 Replicon chromosome
Accession NZ_CP025542
Organism Pseudomonas fluorescens strain 2P24

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag C0J56_RS01970 Protein ID WP_134922454.1
Coordinates 446368..446787 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A923FFX2
Locus tag C0J56_RS01975 Protein ID WP_058546214.1
Coordinates 446787..447017 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C0J56_RS01945 442397..443086 - 690 WP_134922449.1 ABC transporter permease -
C0J56_RS01950 443083..443778 - 696 WP_134922450.1 ABC transporter permease -
C0J56_RS01955 443856..444605 - 750 WP_134922451.1 ABC transporter substrate-binding protein -
C0J56_RS01960 444619..445392 - 774 WP_134922452.1 ABC transporter ATP-binding protein -
C0J56_RS01965 445694..446194 - 501 WP_134922453.1 hypothetical protein -
C0J56_RS01970 446368..446787 - 420 WP_134922454.1 tRNA(fMet)-specific endonuclease VapC Toxin
C0J56_RS01975 446787..447017 - 231 WP_058546214.1 antitoxin Antitoxin
C0J56_RS01980 447200..447649 + 450 WP_134922455.1 carboxypeptidase-like regulatory domain-containing protein -
C0J56_RS01985 447659..448105 - 447 WP_134922456.1 hypothetical protein -
C0J56_RS01990 448146..450380 - 2235 WP_134922457.1 GAF domain-containing protein -
C0J56_RS01995 450377..450982 - 606 WP_134922458.1 biliverdin-producing heme oxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15296.90 Da        Isoelectric Point: 7.2919

>T90544 WP_134922454.1 NZ_CP025542:c446787-446368 [Pseudomonas fluorescens]
MIKFMLDTNVCIFTIKNKPQIVREAFNLHHGQLCISAVTLMELIYGAEKSSAPEKNLGVIEGFCARLEVLPFGYDAAAHT
GMIRAELAKIGRPIGPYDQMIAGHARSLGLIVVTNNLKEFERVPGLRIEDWTTATTPGL

Download         Length: 420 bp

>T90544 NZ_CP025542:c446787-446368 [Pseudomonas fluorescens]
ATGATCAAATTCATGCTCGATACCAACGTTTGTATTTTCACCATCAAGAATAAACCCCAGATCGTTAGAGAAGCCTTCAA
TCTTCATCACGGCCAGCTCTGCATTAGCGCCGTCACGCTGATGGAATTGATCTACGGCGCAGAAAAGTCATCCGCCCCGG
AGAAAAATCTCGGCGTCATCGAAGGGTTCTGTGCCCGACTTGAGGTTTTACCTTTTGGTTATGACGCCGCAGCACATACC
GGAATGATCCGGGCAGAGCTGGCAAAGATAGGCAGGCCAATCGGCCCCTACGACCAGATGATTGCCGGCCATGCCCGTTC
CCTCGGGCTGATCGTAGTCACCAACAATCTGAAAGAATTCGAAAGAGTCCCCGGACTGCGCATCGAGGACTGGACCACTG
CGACTACACCTGGGTTGTAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8503.52 Da        Isoelectric Point: 4.3719

>AT90544 WP_058546214.1 NZ_CP025542:c447017-446787 [Pseudomonas fluorescens]
MEQTTLFMSNRSQAVRLPKAVAMPSDVKRVDVIAIGRARIITPAGEAWDSWFDGDSATADFMAEREQPADQERESF

Download         Length: 231 bp

>AT90544 NZ_CP025542:c447017-446787 [Pseudomonas fluorescens]
ATGGAACAAACCACCCTTTTCATGAGCAACCGCAGCCAAGCGGTCCGGCTACCCAAAGCTGTGGCGATGCCAAGCGACGT
AAAGCGTGTAGACGTGATCGCCATAGGCAGGGCCCGCATCATCACGCCGGCCGGCGAAGCGTGGGATAGCTGGTTCGATG
GCGATAGCGCGACAGCAGACTTTATGGCAGAGCGTGAGCAGCCTGCCGATCAGGAGCGTGAGTCTTTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References