Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/PRK09812-MazE
Location 3568113..3568703 Replicon chromosome
Accession NZ_CP025541
Organism Klebsiella pneumoniae strain 2N3

Toxin (Protein)


Gene name pemK Uniprot ID -
Locus tag CY657_RS17490 Protein ID WP_032421545.1
Coordinates 3568113..3568445 (-) Length 111 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID -
Locus tag CY657_RS17495 Protein ID WP_096106567.1
Coordinates 3568446..3568703 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CY657_RS17475 3564132..3566117 - 1986 WP_040220518.1 DUF3732 domain-containing protein -
CY657_RS17480 3566117..3566611 - 495 WP_000881071.1 hypothetical protein -
CY657_RS17485 3566615..3567826 - 1212 WP_038807401.1 hypothetical protein -
CY657_RS17490 3568113..3568445 - 333 WP_032421545.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
CY657_RS17495 3568446..3568703 - 258 WP_096106567.1 antitoxin Antitoxin
CY657_RS17505 3569038..3569244 - 207 WP_096106566.1 helix-turn-helix domain-containing protein -
CY657_RS17510 3569241..3569701 - 461 Protein_3383 hypothetical protein -
CY657_RS17515 3569984..3570532 - 549 WP_096106565.1 hypothetical protein -
CY657_RS17520 3570611..3572359 - 1749 WP_096106564.1 hypothetical protein -
CY657_RS17525 3572626..3572868 + 243 WP_022615591.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-109)

Antitoxin

Antitoxin PemI-like

(4-84)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 11917.79 Da        Isoelectric Point: 10.0968

>T90541 WP_032421545.1 NZ_CP025541:c3568445-3568113 [Klebsiella pneumoniae]
MDRGEIWLVSLDPTSGHEQSGKRPVLIVSKASFNKLTQLPVIVPVTSGGNFARTAGFTVSLEEAGTKTTGVIRCDQPRTI
DMAARKGKRLERIPDVVVNEVLARLDAMLS

Download         Length: 333 bp

>T90541 NZ_CP025541:c3568445-3568113 [Klebsiella pneumoniae]
ATGGACAGAGGGGAAATCTGGCTCGTTTCACTGGATCCCACCAGCGGCCATGAACAAAGCGGAAAACGTCCGGTACTCAT
CGTGTCGAAGGCATCATTTAACAAGCTGACCCAGCTACCCGTTATTGTTCCCGTCACCAGCGGCGGAAACTTTGCACGTA
CAGCAGGTTTCACGGTTTCACTGGAAGAGGCGGGGACCAAAACAACAGGCGTTATTCGCTGCGACCAGCCCAGGACTATC
GATATGGCGGCCCGGAAAGGCAAGCGTCTGGAACGAATACCTGACGTCGTTGTCAACGAGGTGCTTGCCAGGCTGGATGC
GATGCTGAGTTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9189.65 Da        Isoelectric Point: 4.7468

>AT90541 WP_096106567.1 NZ_CP025541:c3568703-3568446 [Klebsiella pneumoniae]
MYTTRLKKVGGSIMLAVPPAVLKTLGLSTDSEVGMTIDNGCLVIEPQKRPHYSLEELLAQCDPHAEISEGGREWIDAPAV
GKEIL

Download         Length: 258 bp

>AT90541 NZ_CP025541:c3568703-3568446 [Klebsiella pneumoniae]
ATGTATACAACTCGCCTGAAAAAGGTCGGCGGATCCATCATGCTGGCGGTTCCCCCCGCCGTGCTGAAAACGCTGGGGCT
GTCGACGGACAGCGAAGTGGGCATGACCATTGATAATGGCTGCCTGGTTATTGAACCTCAAAAACGTCCTCACTATTCGC
TTGAAGAACTGCTGGCGCAGTGCGATCCGCACGCTGAAATAAGCGAAGGGGGGCGTGAATGGATTGATGCGCCTGCGGTG
GGCAAGGAGATCCTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References