Detailed information of TA system TA090525

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-DinJ
• Location: 1238247..1238803
• Replicon: chromosome
• Accession: NZ_CP025536
• Organism: Streptococcus pluranimalium strain TH11417

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: C0J00_RS06345
• Protein ID: WP_104968080.1
• Coordinates: 1238531..1238803 (+)
• Length: 91 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: C0J00_RS06340
• Protein ID: WP_104968079.1
• Coordinates: 1238247..1238528 (+)
• Length: 94 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C0J00_RS06310	1233517..1235109	-	1593	WP_104968073.1	terminase large subunit	-
C0J00_RS06315	1235106..1235579	-	474	WP_104968074.1	phage terminase small subunit P27 family	-
C0J00_RS06320	1235639..1235845	-	207	WP_104968075.1	DUF4314 domain-containing protein	-
C0J00_RS06325	1235845..1236108	-	264	WP_104968076.1	hypothetical protein	-
C0J00_RS06330	1236169..1237452	-	1284	WP_104968077.1	DNA modification methylase	-
C0J00_RS06335	1237464..1237880	-	417	WP_104968078.1	hypothetical protein	-
C0J00_RS06340	1238247..1238528	+	282	WP_104968079.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
C0J00_RS06345	1238531..1238803	+	273	WP_104968080.1	type II toxin-antitoxin system YafQ family toxin	Toxin
C0J00_RS06350	1238826..1239191	-	366	WP_104968081.1	HNH endonuclease	-
C0J00_RS10490	1239241..1239411	-	171	WP_177216649.1	hypothetical protein	-
C0J00_RS06355	1239501..1240538	-	1038	WP_104968082.1	methionine adenosyltransferase	-
C0J00_RS06360	1240776..1241258	-	483	WP_104968083.1	hypothetical protein	-
C0J00_RS06365	1241773..1242123	-	351	WP_104968084.1	type II toxin-antitoxin system PemK/MazF family toxin	-
C0J00_RS06370	1242132..1242623	-	492	WP_104968085.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (1-90)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (5-72)

Sequences

Toxin

Protein

• Length: 91 a.a.
• Molecular weight: 10290.04 Da
• Isoelectric Point: 9.1473

>T90525 WP_104968080.1 NZ_CP025536:1238531-1238803 [Streptococcus pluranimalium]
MLTLVTTNQFKKDLKRIKKRGLALSKLEAVLDCLLKEQTLDPKHRDHALVGNYIGFRECHIEPDWLLVYAIDKGQLILTA
SRTGSHSDLF

Nucleotide

• Length: 273 bp

>T90525 NZ_CP025536:1238531-1238803 [Streptococcus pluranimalium]
ATGTTAACCTTAGTAACCACCAATCAGTTTAAAAAAGACCTCAAACGTATCAAGAAACGTGGTCTTGCATTGAGCAAATT
AGAAGCTGTCCTTGACTGTCTTCTTAAGGAGCAAACGCTAGACCCAAAGCACCGTGATCACGCCTTAGTTGGAAACTACA
TCGGTTTTCGTGAATGTCACATTGAACCTGACTGGCTTTTAGTTTACGCCATTGATAAGGGTCAGTTAATTCTTACCGCA
TCACGGACAGGTTCTCACTCGGATTTATTTTAG

Antitoxin

Protein

• Length: 94 a.a.
• Molecular weight: 10335.62 Da
• Isoelectric Point: 4.5659

>AT90525 WP_104968079.1 NZ_CP025536:1238247-1238528 [Streptococcus pluranimalium]
MAKTANINLRIEPATKSQAEALFNSFGISVTDAINIFLNTSIMEGGFPFQIKQPRYNQETEAAIKEARQIMAGTTKAERY
NSVSELFSSLDEE

Nucleotide

• Length: 282 bp

>AT90525 NZ_CP025536:1238247-1238528 [Streptococcus pluranimalium]
ATGGCAAAAACAGCAAACATTAATCTACGTATTGAACCCGCAACTAAATCCCAAGCTGAAGCTCTCTTTAATAGTTTTGG
TATTTCAGTAACAGATGCTATCAACATCTTTCTAAACACGTCCATCATGGAAGGTGGATTTCCTTTTCAAATTAAACAAC
CTCGCTATAACCAAGAGACAGAAGCTGCTATTAAAGAGGCTCGTCAGATCATGGCAGGAACCACCAAGGCTGAGCGTTAC
AATAGTGTTTCCGAGCTCTTTTCATCTCTTGATGAGGAGTAG