Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1993217..1993815 Replicon chromosome
Accession NZ_CP025512
Organism Neorhizobium sp. SOG26

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag CYG48_RS09875 Protein ID WP_118851589.1
Coordinates 1993217..1993405 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag CYG48_RS09880 Protein ID WP_118850226.1
Coordinates 1993411..1993815 (+) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CYG48_RS09865 1991862..1992335 + 474 WP_118850224.1 Lrp/AsnC ligand binding domain-containing protein -
CYG48_RS09870 1992360..1993106 - 747 WP_118850225.1 hypothetical protein -
CYG48_RS09875 1993217..1993405 + 189 WP_118851589.1 type II toxin-antitoxin system HicA family toxin Toxin
CYG48_RS09880 1993411..1993815 + 405 WP_118850226.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
CYG48_RS09885 1993828..1994184 - 357 WP_118850227.1 hydroxyisourate hydrolase -
CYG48_RS09890 1994181..1994681 - 501 WP_118850228.1 ureidoglycolate lyase -
CYG48_RS09895 1994681..1995043 - 363 WP_118850229.1 DUF86 domain-containing protein -
CYG48_RS09900 1995040..1995330 - 291 WP_118851590.1 nucleotidyltransferase family protein -
CYG48_RS09905 1995387..1996409 - 1023 WP_118850230.1 allantoicase -
CYG48_RS09910 1996406..1996909 - 504 WP_118850231.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
CYG48_RS09915 1996906..1997832 - 927 WP_118850232.1 allantoinase PuuE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-124)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 6947.22 Da        Isoelectric Point: 11.6882

>T90463 WP_118851589.1 NZ_CP025512:1993217-1993405 [Neorhizobium sp. SOG26]
MKSAEVIALLRKDGWVEVAQRGSHIQFKHPVKPGRATVPHPKRDIPLGTLRSIEKQAGIKLR

Download         Length: 189 bp

>T90463 NZ_CP025512:1993217-1993405 [Neorhizobium sp. SOG26]
ATGAAGAGCGCCGAGGTCATCGCACTGCTGCGCAAGGATGGCTGGGTTGAAGTTGCTCAACGCGGCAGCCACATCCAGTT
CAAACATCCTGTGAAACCGGGCCGAGCAACGGTCCCACATCCGAAGCGGGACATCCCGCTCGGCACGCTGCGCAGCATCG
AGAAGCAGGCAGGCATCAAGCTGAGGTAA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14241.01 Da        Isoelectric Point: 4.1867

>AT90463 WP_118850226.1 NZ_CP025512:1993411-1993815 [Neorhizobium sp. SOG26]
MSNYIGLIHKEPDSDYGVSFPDFPGLITAAPTLDEARQMAEEALAFHVEGMIGDGDAIPEPSTLESIMTDPSNKDGVAVL
VSLKTAAAKAVRINITLPEDVLQTVDAYAEARGLSRSGFLARAAIHEIERETAG

Download         Length: 405 bp

>AT90463 NZ_CP025512:1993411-1993815 [Neorhizobium sp. SOG26]
ATGAGCAACTACATCGGTCTCATCCACAAGGAACCGGACAGTGACTACGGCGTGTCCTTTCCGGACTTCCCGGGGCTTAT
AACGGCTGCACCCACGCTGGACGAGGCGCGGCAGATGGCCGAAGAAGCGTTGGCTTTTCATGTCGAAGGAATGATCGGGG
ACGGTGACGCCATTCCAGAGCCATCAACCCTGGAAAGCATCATGACTGACCCGTCAAACAAGGACGGCGTGGCGGTACTC
GTGAGCCTGAAGACCGCCGCTGCCAAGGCCGTGCGCATCAACATCACGCTACCGGAAGACGTGCTGCAAACGGTCGATGC
TTATGCCGAAGCACGGGGCCTATCGCGCTCCGGATTCCTCGCACGCGCAGCGATCCACGAGATTGAACGAGAGACCGCCG
GCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References