Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 657066..657649 Replicon chromosome
Accession NZ_CP025512
Organism Neorhizobium sp. SOG26

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag CYG48_RS03215 Protein ID WP_118849054.1
Coordinates 657066..657431 (-) Length 122 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag CYG48_RS03220 Protein ID WP_118849055.1
Coordinates 657428..657649 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CYG48_RS03190 652238..653128 - 891 WP_118849049.1 LysR family transcriptional regulator -
CYG48_RS03195 653231..654052 + 822 WP_118849050.1 class D beta-lactamase -
CYG48_RS03200 654073..654267 - 195 WP_118849051.1 hypothetical protein -
CYG48_RS03205 654328..655116 - 789 WP_118849052.1 SDR family oxidoreductase -
CYG48_RS03210 655385..657061 + 1677 WP_118849053.1 electron transfer flavoprotein-ubiquinone oxidoreductase -
CYG48_RS03215 657066..657431 - 366 WP_118849054.1 PIN domain-containing protein Toxin
CYG48_RS03220 657428..657649 - 222 WP_118849055.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
CYG48_RS03225 657817..658428 + 612 WP_118849056.1 L,D-transpeptidase -
CYG48_RS03230 658487..658903 - 417 WP_118849057.1 DoxX family protein -
CYG48_RS03235 659007..660023 - 1017 WP_118849058.1 zinc-binding alcohol dehydrogenase family protein -
CYG48_RS03240 660144..661385 - 1242 WP_118849059.1 MFS transporter -
CYG48_RS03245 661684..662622 + 939 WP_118849060.1 diacylglycerol kinase family lipid kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-112)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(1-47)


Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 13283.51 Da        Isoelectric Point: 6.8803

>T90461 WP_118849054.1 NZ_CP025512:c657431-657066 [Neorhizobium sp. SOG26]
MIIIDTSVWINHIRQPEVEVELLLKRDQALVRPFVIGELALGNMKRHDEIIDALLQMRPAAVAQTDDVLTIIKRHALSGS
GIGYVDAHLLASAAMAAGTRIFTRDKRLAKVATALDLAYDG

Download         Length: 366 bp

>T90461 NZ_CP025512:c657431-657066 [Neorhizobium sp. SOG26]
TTGATCATCATCGACACCTCCGTCTGGATCAATCACATTCGTCAGCCGGAGGTGGAGGTGGAGCTTCTTCTCAAGCGAGA
TCAAGCGCTGGTCCGCCCCTTCGTCATCGGAGAACTGGCGCTCGGCAACATGAAGCGTCACGACGAGATCATCGACGCGC
TCCTCCAGATGCGTCCGGCCGCAGTCGCACAAACTGACGACGTACTGACCATCATTAAGCGGCACGCGCTTTCGGGGAGC
GGGATTGGCTACGTCGACGCCCACCTGCTGGCCTCAGCAGCGATGGCTGCCGGGACACGCATCTTCACCCGCGACAAGCG
CCTCGCGAAGGTCGCGACGGCGCTTGATCTGGCTTACGACGGCTAG

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8030.02 Da        Isoelectric Point: 5.6401

>AT90461 WP_118849055.1 NZ_CP025512:c657649-657428 [Neorhizobium sp. SOG26]
MHMTITIDDELLSKAREATGLQETDAVVKAALMAVVQRNAAQKLIELGGSDPNATAAPRRRWKSDGTWQENHD

Download         Length: 222 bp

>AT90461 NZ_CP025512:c657649-657428 [Neorhizobium sp. SOG26]
ATGCATATGACGATCACCATCGACGACGAATTGCTCTCGAAGGCAAGAGAAGCGACAGGCCTGCAGGAAACAGACGCAGT
CGTGAAGGCGGCGTTGATGGCCGTTGTTCAGCGTAACGCGGCCCAGAAGCTGATCGAGCTTGGCGGAAGCGATCCCAATG
CCACTGCAGCGCCTAGACGACGCTGGAAATCTGACGGCACGTGGCAGGAAAATCACGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References