Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 573545..574128 Replicon chromosome
Accession NZ_CP025512
Organism Neorhizobium sp. SOG26

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag CYG48_RS02770 Protein ID WP_118848982.1
Coordinates 573545..573799 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag CYG48_RS02775 Protein ID WP_199925266.1
Coordinates 573808..574128 (+) Length 107 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CYG48_RS02735 568852..569118 + 267 WP_118848976.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
CYG48_RS02740 569115..569561 + 447 WP_118848977.1 type II toxin-antitoxin system VapC family toxin -
CYG48_RS02745 569601..570443 + 843 WP_118848978.1 metallophosphoesterase -
CYG48_RS02750 570456..571154 - 699 WP_118848979.1 YafY family transcriptional regulator -
CYG48_RS02755 571289..571921 + 633 WP_118851456.1 LysE family translocator -
CYG48_RS02760 572078..572515 + 438 WP_118848980.1 cytochrome c -
CYG48_RS02765 572588..573505 + 918 WP_118848981.1 cytochrome c -
CYG48_RS02770 573545..573799 + 255 WP_118848982.1 type II toxin-antitoxin system HicA family toxin Toxin
CYG48_RS02775 573808..574128 + 321 WP_199925266.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
CYG48_RS02780 574140..574709 - 570 WP_118848984.1 DJ-1/PfpI family protein -
CYG48_RS02785 574732..575232 - 501 WP_118851457.1 GNAT family N-acetyltransferase -
CYG48_RS02790 575313..575603 + 291 WP_118848985.1 hypothetical protein -
CYG48_RS02795 575624..575893 - 270 WP_118848986.1 hypothetical protein -
CYG48_RS02800 576058..578166 - 2109 WP_118848987.1 S9 family peptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(23-73)

Antitoxin

Uncharacterised protein family HicB

(51-101)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9614.14 Da        Isoelectric Point: 10.7098

>T90459 WP_118848982.1 NZ_CP025512:573545-573799 [Neorhizobium sp. SOG26]
MNSRHRKTLEAVFRDPVSRTLEWAAIESLLLSLGCDIIEGSGSRVRFHKDGKVETFHRPHPAKEAKQYQVRAARAYLIRL
GIMP

Download         Length: 255 bp

>T90459 NZ_CP025512:573545-573799 [Neorhizobium sp. SOG26]
ATGAACAGCAGGCACCGCAAGACGCTTGAGGCGGTCTTCCGAGACCCAGTCTCGAGAACGCTGGAGTGGGCGGCGATTGA
AAGCCTGTTGCTCTCCCTCGGCTGCGACATCATCGAAGGAAGCGGCTCGCGCGTCCGCTTTCATAAAGATGGCAAGGTCG
AAACGTTTCATCGTCCACATCCCGCAAAGGAAGCCAAACAGTACCAGGTGCGGGCAGCGCGCGCGTACCTGATCCGATTG
GGAATCATGCCATGA

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 11605.95 Da        Isoelectric Point: 4.7552

>AT90459 WP_199925266.1 NZ_CP025512:573808-574128 [Neorhizobium sp. SOG26]
MTYKGYSARIEYDDEDGIFFGRLAGISDGVGFHADNVEELRTAFRESVDDYIETCAKIGKSPEKPYSGKVMFRIDPEVHA
RAARAAELAGKSLNEWAGEVLAKAAG

Download         Length: 321 bp

>AT90459 NZ_CP025512:573808-574128 [Neorhizobium sp. SOG26]
ATGACCTACAAAGGTTATTCCGCTCGCATCGAGTATGACGATGAGGACGGAATCTTCTTCGGGCGCCTAGCAGGCATTAG
CGATGGTGTCGGTTTTCATGCGGACAATGTCGAGGAACTGCGGACCGCTTTCAGGGAATCCGTCGATGACTACATCGAAA
CCTGCGCCAAGATCGGCAAGTCACCTGAAAAACCTTATTCCGGCAAGGTGATGTTCCGTATCGATCCTGAAGTTCATGCG
CGGGCAGCGCGGGCCGCGGAACTTGCGGGCAAGAGCCTCAACGAATGGGCAGGGGAAGTGCTGGCCAAGGCCGCCGGTTA
A

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References