Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 3025418..3026852 Replicon chromosome
Accession NZ_CP025491
Organism Legionella sainthelensi strain LA01-117

Toxin (Protein)


Gene name HipA1 Uniprot ID -
Locus tag CAB17_RS13340 Protein ID WP_101898591.1
Coordinates 3025632..3026852 (+) Length 407 a.a.

Antitoxin (Protein)


Gene name HipB1 Uniprot ID -
Locus tag CAB17_RS13335 Protein ID WP_101898590.1
Coordinates 3025418..3025645 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CAB17_RS13315 3021091..3021618 - 528 WP_101898588.1 hypothetical protein -
CAB17_RS13320 3021996..3022361 - 366 WP_129556898.1 TraK family protein -
CAB17_RS13325 3022681..3024431 - 1751 Protein_2603 DUF927 domain-containing protein -
CAB17_RS13330 3024498..3024773 - 276 WP_101898589.1 DNA-binding protein -
CAB17_RS13335 3025418..3025645 + 228 WP_101898590.1 helix-turn-helix transcriptional regulator Antitoxin
CAB17_RS13340 3025632..3026852 + 1221 WP_101898591.1 type II toxin-antitoxin system HipA family toxin Toxin
CAB17_RS13345 3027110..3028621 + 1512 WP_101898592.1 Fic family protein -
CAB17_RS13350 3028658..3029365 + 708 WP_101898593.1 hypothetical protein -
CAB17_RS13355 3029754..3029981 + 228 WP_101898594.1 helix-turn-helix transcriptional regulator -
CAB17_RS13360 3029978..3030286 + 309 WP_101898595.1 HipA N-terminal domain-containing protein -
CAB17_RS13365 3030283..3031221 + 939 WP_101898596.1 lpg2370 family Dot/Icm T4SS effector -
CAB17_RS13370 3031310..3031495 - 186 Protein_2612 integrase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(7-104)

Antitoxin

Cro/C1-type helix-turn-helix domain

(12-61)


Sequences

Toxin        


Download         Length: 407 a.a.        Molecular weight: 45586.72 Da        Isoelectric Point: 7.9867

>T90428 WP_101898591.1 NZ_CP025491:3025632-3026852 [Legionella sainthelensi]
MKNHKLGVYLNQILAGQLSIDTRGDMSFEYDNYYLENKQNRPLSHSLPLQKASYSTKQCRPFFSGLLPEAHMRTAIARQL
GISEKNDFALLAAIGGECAGAVMILPQNTSIAQLKPDYKIIKKKDVLEILQTMHQRPMIVGEDGVRLSLAGAQDKLPVAI
IEENLAIPMNGAPSTHILKPINRDFPTLIENECFCLNLAQKIGLNAVDAAIHYADDTPYLLVKRYDRVETEQGIQRLHQE
DFCQALGISPEMKYQREGGPKISECFGLIREISSLPIFDIKELLQGILFNVIIGNNDAHSKNFSLLYHGSKTRLAPFYDM
ISTIYYPNLSSKMAMKVGSKYDFDGLFPRHFTQMAEEALLSGALVRKEVLDLVSKIQKNITASPFTGIILQRADKLFQRF
QKSSAE

Download         Length: 1221 bp

>T90428 NZ_CP025491:3025632-3026852 [Legionella sainthelensi]
ATGAAAAATCATAAACTGGGTGTCTATCTTAACCAAATATTAGCAGGCCAATTAAGTATTGATACGCGTGGCGATATGTC
TTTTGAGTATGACAATTATTATCTGGAAAACAAGCAAAATCGCCCCTTGTCACACTCCCTCCCTCTTCAAAAAGCCTCTT
ACTCAACAAAACAATGCCGCCCGTTTTTTAGTGGACTCTTGCCTGAAGCCCATATGCGCACAGCAATTGCTCGTCAATTG
GGTATCAGTGAAAAAAATGATTTTGCTTTGTTAGCTGCTATTGGTGGTGAGTGTGCCGGGGCGGTGATGATATTGCCGCA
AAATACATCCATAGCTCAGCTAAAGCCAGACTATAAAATTATCAAAAAAAAGGACGTATTAGAAATCCTGCAAACTATGC
ATCAACGACCTATGATAGTTGGTGAGGATGGAGTCCGGCTATCCCTTGCAGGCGCGCAGGATAAGCTCCCAGTTGCTATT
ATTGAAGAAAATCTTGCCATACCAATGAACGGTGCGCCCAGTACTCACATTTTAAAACCAATCAATCGAGACTTTCCCAC
CCTAATTGAAAATGAGTGCTTCTGCCTTAATCTGGCACAAAAAATTGGATTAAATGCTGTGGACGCAGCTATCCATTATG
CCGATGATACCCCTTATCTGTTAGTTAAACGTTATGATCGGGTTGAGACAGAGCAAGGAATCCAACGCCTTCATCAAGAA
GATTTTTGTCAGGCACTAGGCATAAGCCCTGAGATGAAATATCAGCGAGAAGGTGGCCCCAAAATTAGTGAGTGCTTTGG
TTTGATAAGAGAGATATCAAGTCTCCCTATCTTTGACATTAAAGAATTATTACAGGGGATTCTGTTTAATGTGATTATTG
GCAACAATGATGCACATAGCAAAAATTTCTCTTTGCTCTACCATGGTTCAAAAACTCGTTTAGCACCTTTCTACGATATG
ATTTCAACCATATATTATCCTAATCTTTCTAGTAAAATGGCAATGAAAGTTGGTAGTAAATATGATTTTGATGGCCTCTT
CCCACGTCACTTTACACAAATGGCAGAAGAGGCTCTTTTATCTGGCGCCCTAGTACGTAAAGAAGTCTTGGATCTAGTTA
GCAAAATTCAAAAAAACATAACAGCAAGCCCCTTTACCGGCATTATTTTGCAACGTGCTGACAAATTATTTCAAAGGTTT
CAGAAGTCTTCAGCAGAATAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8380.82 Da        Isoelectric Point: 8.5275

>AT90428 WP_101898590.1 NZ_CP025491:3025418-3025645 [Legionella sainthelensi]
MIQSPEKIGCYIRKVRKELNVTQKDLALTAGTGLRFIIDLENGKPTCQIGKILQVLQVLGIQLNLSHADFENEKS

Download         Length: 228 bp

>AT90428 NZ_CP025491:3025418-3025645 [Legionella sainthelensi]
ATGATTCAATCTCCAGAAAAAATAGGATGTTATATTCGCAAAGTTCGTAAAGAACTTAATGTTACCCAAAAAGATTTGGC
TTTAACTGCTGGAACTGGATTGCGTTTTATTATTGATTTGGAAAATGGAAAGCCAACTTGCCAAATTGGAAAAATACTGC
AAGTACTACAAGTACTTGGGATTCAACTCAACTTATCTCATGCTGATTTCGAAAATGAAAAATCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References