90417

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB(antitoxin)
Location 540603..541271 Replicon chromosome
Accession NZ_CP025473
Organism Enterococcus mundtii strain Pe161

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag CYK55_RS02865 Protein ID WP_080693183.1
Coordinates 540603..540776 (+) Length 58 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag CYK55_RS02870 Protein ID WP_126133906.1
Coordinates 540816..541271 (+) Length 152 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CYK55_RS02845 536728..537807 + 1080 WP_126133904.1 prephenate dehydrogenase -
CYK55_RS02850 537812..539095 + 1284 WP_126133905.1 3-phosphoshikimate 1-carboxyvinyltransferase -
CYK55_RS02855 539095..539601 + 507 WP_034690324.1 shikimate kinase -
CYK55_RS02860 539598..540464 + 867 WP_034690322.1 prephenate dehydratase -
CYK55_RS02865 540603..540776 + 174 WP_080693183.1 addiction module toxin, HicA family Toxin
CYK55_RS02870 540816..541271 + 456 WP_126133906.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
CYK55_RS02875 541396..541905 + 510 WP_010736264.1 type 1 glutamine amidotransferase -
CYK55_RS02885 542551..542883 + 333 WP_126133907.1 arsenic metallochaperone ArsD family protein -
CYK55_RS02890 542963..544129 - 1167 WP_126133908.1 galactokinase -
CYK55_RS02895 544126..545166 - 1041 WP_126133909.1 galactose mutarotase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(7-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(18-69)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6028.41 Da        Isoelectric Point: 11.9969

>T90417 WP_080693183.1 NZ_CP025473:540603-540776 [Enterococcus mundtii]
MPMAQQGMVKLLISIGGLKVKGGKGSHIKVKLLGVNRLIIVPSKLPKGTEHATLRQG

Download         Length: 174 bp

>T90417 NZ_CP025473:540603-540776 [Enterococcus mundtii]
ATGCCAATGGCACAACAGGGAATGGTCAAACTCTTGATTTCCATAGGTGGGTTAAAAGTTAAAGGTGGAAAAGGTTCTCA
TATAAAAGTGAAACTACTAGGAGTAAATCGACTAATCATTGTTCCTTCCAAGCTACCTAAAGGGACAGAACATGCGACAC
TGAGGCAGGGTTAA

Antitoxin


Download         Length: 152 a.a.        Molecular weight: 16738.88 Da        Isoelectric Point: 3.8915

>AT90417 WP_126133906.1 NZ_CP025473:540816-541271 [Enterococcus mundtii]
MLVSYPVLFYLETSEDYASGFSVFFPDFPEMSGTSGSDIPEALENASDYLDIFLAAEIAEDRTLPNPSLISSLSLLENNP
IKSGSEFTLEYDAEKSFISMVSVDLTEYLGSEEPIKKTVMIPKWADKLGEEMHLSFSKTLTEAIVREKLGA

Download         Length: 456 bp

>AT90417 NZ_CP025473:540816-541271 [Enterococcus mundtii]
ATGCTTGTTTCATATCCGGTATTATTCTATTTAGAAACAAGTGAAGACTATGCCTCGGGATTTTCTGTTTTCTTTCCAGA
TTTTCCGGAGATGTCTGGTACAAGCGGATCTGATATTCCTGAAGCGCTCGAAAATGCCTCTGATTACTTAGATATTTTTT
TGGCGGCTGAGATAGCAGAAGACCGAACATTACCTAATCCATCTCTTATCAGTTCATTGTCACTTCTAGAAAATAATCCT
ATTAAAAGTGGTTCCGAGTTCACATTAGAATATGATGCTGAAAAATCATTTATTTCAATGGTCTCTGTAGATCTAACAGA
ATATTTAGGCTCAGAGGAACCTATAAAAAAGACGGTAATGATCCCAAAATGGGCAGATAAGTTAGGTGAAGAAATGCATC
TAAGTTTTTCAAAGACATTGACCGAAGCCATTGTTCGTGAAAAACTAGGTGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References