Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 30833..31359 Replicon plasmid p44-1
Accession NZ_CP025462
Organism Klebsiella pneumoniae strain F44

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag CYE02_RS27980 Protein ID WP_000323025.1
Coordinates 30833..31120 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag CYE02_RS27985 Protein ID WP_000534858.1
Coordinates 31120..31359 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CYE02_RS27935 25879..26112 - 234 WP_004181905.1 hypothetical protein -
CYE02_RS27940 26191..26538 - 348 WP_004181904.1 hypothetical protein -
CYE02_RS27945 26694..27761 - 1068 WP_004181903.1 hypothetical protein -
CYE02_RS27960 28451..28828 + 378 WP_004181901.1 hypothetical protein -
CYE02_RS31640 29026..30000 - 975 WP_004181899.1 hypothetical protein -
CYE02_RS27975 30603..30761 - 159 WP_004181898.1 type I toxin-antitoxin system Hok family toxin -
CYE02_RS27980 30833..31120 - 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
CYE02_RS27985 31120..31359 - 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
CYE02_RS27995 31622..32038 - 417 Protein_28 cation-efflux pump -
CYE02_RS28005 32111..33279 + 1169 WP_085929673.1 IS3-like element ISEc52 family transposase -
CYE02_RS28010 33289..33600 - 312 Protein_30 transposase -
CYE02_RS28015 34021..35361 - 1341 WP_000589001.1 ISNCY family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid mph(A) / blaTEM-1B / aac(3)-IId / blaSHV-12 rmpA / iutA / iucD / iucC / iucB / iucA 1..261706 261706


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T90382 WP_000323025.1 NZ_CP025462:c31120-30833 [Klebsiella pneumoniae]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T90382 NZ_CP025462:c31120-30833 [Klebsiella pneumoniae]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT90382 WP_000534858.1 NZ_CP025462:c31359-31120 [Klebsiella pneumoniae]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp

>AT90382 NZ_CP025462:c31359-31120 [Klebsiella pneumoniae]
ATGGGTAGCATTAACCTACGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGCGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGACTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
PDB 4FXE
PDB 2KC8
PDB 2K29
AlphaFold DB A0A4V1CTS8

References