90382

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 30833..31359 Replicon plasmid p44-1
Accession NZ_CP025462
Organism Klebsiella pneumoniae strain F44

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag CYE02_RS27980 Protein ID WP_000323025.1
Coordinates 30833..31120 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag CYE02_RS27985 Protein ID WP_000534858.1
Coordinates 31120..31359 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CYE02_RS27935 25879..26112 - 234 WP_004181905.1 hypothetical protein -
CYE02_RS27940 26191..26538 - 348 WP_004181904.1 hypothetical protein -
CYE02_RS27945 26694..27761 - 1068 WP_004181903.1 hypothetical protein -
CYE02_RS27960 28451..28828 + 378 WP_004181901.1 hypothetical protein -
CYE02_RS31640 29026..30000 - 975 WP_004181899.1 hypothetical protein -
CYE02_RS27975 30603..30761 - 159 WP_004181898.1 type I toxin-antitoxin system Hok family toxin -
CYE02_RS27980 30833..31120 - 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
CYE02_RS27985 31120..31359 - 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
CYE02_RS27995 31622..32038 - 417 Protein_28 cation-efflux pump -
CYE02_RS28005 32111..33279 + 1169 WP_085929673.1 IS3-like element ISEc52 family transposase -
CYE02_RS28010 33289..33600 - 312 Protein_30 transposase -
CYE02_RS28015 34021..35361 - 1341 WP_000589001.1 ISNCY family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid mph(A) / blaTEM-1B / aac(3)-IId / blaSHV-12 rmpA / iutA / iucD / iucC / iucB / iucA 1..261706 261706


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T90382 WP_000323025.1 NZ_CP025462:c31120-30833 [Klebsiella pneumoniae]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T90382 NZ_CP025462:c31120-30833 [Klebsiella pneumoniae]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT90382 WP_000534858.1 NZ_CP025462:c31359-31120 [Klebsiella pneumoniae]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp

>AT90382 NZ_CP025462:c31359-31120 [Klebsiella pneumoniae]
ATGGGTAGCATTAACCTACGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGCGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGACTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
AlphaFold DB A0A4V1CTS8

References