Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4583246..4583900 Replicon chromosome
Accession NZ_CP025461
Organism Klebsiella pneumoniae strain F44

Toxin (Protein)


Gene name cptA Uniprot ID R4YHX2
Locus tag CYE02_RS23245 Protein ID WP_004144731.1
Coordinates 4583246..4583653 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag CYE02_RS23250 Protein ID WP_002916312.1
Coordinates 4583634..4583900 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CYE02_RS23225 4579246..4580979 - 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -
CYE02_RS23230 4580985..4581698 - 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
CYE02_RS23235 4581721..4582617 - 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
CYE02_RS23240 4582718..4583239 + 522 WP_002916308.1 flavodoxin FldB -
CYE02_RS23245 4583246..4583653 - 408 WP_004144731.1 protein YgfX Toxin
CYE02_RS23250 4583634..4583900 - 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
CYE02_RS23255 4584146..4585129 + 984 WP_002916313.1 tRNA-modifying protein YgfZ -
CYE02_RS23260 4585280..4585939 - 660 WP_002916317.1 hemolysin III family protein -
CYE02_RS23265 4586103..4586414 - 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
CYE02_RS23270 4586464..4587192 + 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
CYE02_RS23275 4587311..4588744 + 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15936.69 Da        Isoelectric Point: 11.4778

>T90378 WP_004144731.1 NZ_CP025461:c4583653-4583246 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNAE
WEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 408 bp

>T90378 NZ_CP025461:c4583653-4583246 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCGTGC
GCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCCGAA
TGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGGACA
GCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGGCGC
AGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT90378 WP_002916312.1 NZ_CP025461:c4583900-4583634 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT90378 NZ_CP025461:c4583900-4583634 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A378E4P6

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References