Detailed information of TA system TA090335

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RHH(antitoxin)
• Location: 2390..2949
• Replicon: plasmid pSAG-76334
• Accession: NZ_CP025455
• Organism: Salmonella enterica subsp. enterica serovar Agona strain USDA-ARS-USMARC-76334

Toxin (Protein)

• Gene name: relE
• Uniprot ID: U9YB49
• Locus tag: CYL23_RS23165
• Protein ID: WP_000421259.1
• Coordinates: 2674..2949 (+)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: U9Y625
• Locus tag: CYL23_RS23160
• Protein ID: WP_001178087.1
• Coordinates: 2390..2674 (+)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CYL23_RS23140	455..1486	+	1032	WP_000907852.1	replication initiation protein	-
CYL23_RS23160	2390..2674	+	285	WP_001178087.1	ribbon-helix-helix protein, CopG family	Antitoxin
CYL23_RS23165	2674..2949	+	276	WP_000421259.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
CYL23_RS23170	3055..3336	+	282	WP_006855660.1	hypothetical protein	-
CYL23_RS23180	3760..5091	-	1332	Protein_4	Tn3 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..96532	96532

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (3-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (4-124)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 11810.03 Da
• Isoelectric Point: 12.7590

>T90335 WP_000421259.1 NZ_CP025455:2674-2949 [Salmonella enterica subsp. enterica serovar Agona]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKK

Nucleotide

• Length: 276 bp

>T90335 NZ_CP025455:2674-2949 [Salmonella enterica subsp. enterica serovar Agona]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 12194.55 Da
• Isoelectric Point: 12.7731

>AT90335 WP_001178087.1 NZ_CP025455:2390-2674 [Salmonella enterica subsp. enterica serovar Agona]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKK

Nucleotide

• Length: 285 bp

>AT90335 NZ_CP025455:2390-2674 [Salmonella enterica subsp. enterica serovar Agona]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Structures

Toxin

• AlphaFold DB: U9YB49

Antitoxin

• AlphaFold DB: U9Y625