Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-MazE
Location 89419..90040 Replicon plasmid pPZ03
Accession NZ_CP025433
Organism Paracoccus zhejiangensis strain J6

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag CX676_RS22005 Protein ID WP_101754919.1
Coordinates 89419..89820 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag CX676_RS22010 Protein ID WP_101754920.1
Coordinates 89810..90040 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CX676_RS21980 85261..85572 - 312 WP_101754915.1 hypothetical protein -
CX676_RS21985 85569..85841 - 273 WP_101754968.1 hypothetical protein -
CX676_RS21990 86257..86991 - 735 WP_101754916.1 Crp/Fnr family transcriptional regulator -
CX676_RS21995 87145..87381 + 237 WP_101754917.1 hypothetical protein -
CX676_RS22000 87518..89095 + 1578 WP_101754918.1 chaperonin GroEL -
CX676_RS22005 89419..89820 - 402 WP_101754919.1 PIN domain-containing protein Toxin
CX676_RS22010 89810..90040 - 231 WP_101754920.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
CX676_RS22015 90120..91994 - 1875 WP_101754921.1 relaxase/mobilization nuclease domain-containing protein -
CX676_RS22020 91991..92536 - 546 WP_101754922.1 plasmid mobilization relaxosome protein MobC -
CX676_RS22025 93285..93632 + 348 WP_101754923.1 hypothetical protein -
CX676_RS22030 94298..94615 + 318 WP_101754924.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..150390 150390


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-116)

Antitoxin

SpoVT-AbrB domain

(5-33)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14839.10 Da        Isoelectric Point: 4.8997

>T90330 WP_101754919.1 NZ_CP025433:c89820-89419 [Paracoccus zhejiangensis]
MPGRFFDTNVLLYLLSEDRAKADVAECLLRGGGTVSVQVLNEIANVTRRKFRMSWAQSDEFLLMIREFVTVEPLTYETHD
LGIALARKHALSVYDAMIVAAGLLAGCDNLLSEDMQDGFRVADRITIRNPFAA

Download         Length: 402 bp

>T90330 NZ_CP025433:c89820-89419 [Paracoccus zhejiangensis]
ATGCCAGGTAGGTTCTTCGACACCAACGTCCTGCTTTACCTGCTCTCTGAAGACCGTGCCAAGGCAGACGTTGCCGAATG
TCTGCTGCGCGGCGGCGGAACCGTCAGCGTGCAGGTGCTGAACGAGATCGCGAACGTCACGCGGCGGAAGTTCAGGATGA
GTTGGGCGCAGAGCGATGAATTTCTGCTCATGATCCGTGAGTTTGTGACCGTCGAGCCACTGACCTATGAGACGCATGAT
CTGGGCATCGCCCTGGCGCGGAAGCACGCGCTGTCTGTCTATGACGCGATGATCGTTGCGGCCGGGCTGCTGGCTGGCTG
TGATAACCTGCTTTCCGAGGACATGCAGGACGGGTTCAGGGTGGCCGACAGGATCACGATCAGGAATCCCTTCGCCGCAT
GA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8803.11 Da        Isoelectric Point: 10.4416

>AT90330 WP_101754920.1 NZ_CP025433:c90040-89810 [Paracoccus zhejiangensis]
MQIAKWGNSLAVRLPARMVQELGLKAGDEIEITAADAGHFEVHRRRDPEEILARLRKFRGLMPKDYRFDRNEANAR

Download         Length: 231 bp

>AT90330 NZ_CP025433:c90040-89810 [Paracoccus zhejiangensis]
ATGCAGATCGCGAAATGGGGCAATTCTCTGGCCGTCCGCCTGCCTGCGCGGATGGTCCAGGAACTCGGGTTGAAGGCGGG
CGACGAGATCGAAATCACCGCGGCCGATGCCGGGCATTTTGAGGTTCATCGCCGCCGCGATCCCGAAGAAATCCTGGCCC
GGCTTCGCAAGTTTCGCGGATTGATGCCCAAGGACTACCGGTTCGACCGGAACGAGGCGAATGCCAGGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References