Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-MazE
Location 99610..100231 Replicon plasmid pPZ02
Accession NZ_CP025432
Organism Paracoccus zhejiangensis strain J6

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag CX676_RS20990 Protein ID WP_101754740.1
Coordinates 99830..100231 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag CX676_RS20985 Protein ID WP_101754739.1
Coordinates 99610..99840 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CX676_RS20965 95034..95351 - 318 WP_101754735.1 hypothetical protein -
CX676_RS20970 96018..96365 - 348 WP_157936030.1 hypothetical protein -
CX676_RS20975 97073..97660 + 588 WP_157936031.1 plasmid mobilization relaxosome protein MobC -
CX676_RS20980 97657..99531 + 1875 WP_101754738.1 relaxase/mobilization nuclease domain-containing protein -
CX676_RS20985 99610..99840 + 231 WP_101754739.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
CX676_RS20990 99830..100231 + 402 WP_101754740.1 PIN domain-containing protein Toxin
CX676_RS20995 100491..100868 - 378 WP_101754741.1 hypothetical protein -
CX676_RS21000 100884..101576 - 693 WP_101754742.1 ABC transporter ATP-binding protein -
CX676_RS21005 101581..102714 - 1134 WP_101754743.1 ABC transporter permease -
CX676_RS21010 102711..103856 - 1146 WP_101754744.1 efflux RND transporter periplasmic adaptor subunit -
CX676_RS21015 103860..104456 - 597 WP_101754745.1 TetR/AcrR family transcriptional regulator -
CX676_RS21020 104554..104826 - 273 WP_101754746.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..214101 214101


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-116)

Antitoxin

SpoVT-AbrB domain

(5-33)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14798.05 Da        Isoelectric Point: 4.8998

>T90329 WP_101754740.1 NZ_CP025432:99830-100231 [Paracoccus zhejiangensis]
MPGRFFDTNVLLYLLSEDRAKADIAEGLLRGGGTVSVQVLNEIANVTRRKFRMSWAQSDEFLLMLREFVTVEPLTYETHD
LGIALARKHALSVYDAMIVAAGLMAGCDTVLSEDMQDGFRVADRITIRNPFAA

Download         Length: 402 bp

>T90329 NZ_CP025432:99830-100231 [Paracoccus zhejiangensis]
ATGCCAGGTAGGTTCTTCGACACGAACGTCCTGCTTTACCTGCTCTCTGAAGACCGTGCCAAGGCCGACATCGCCGAAGG
GCTGCTGCGCGGCGGCGGAACCGTCAGTGTGCAGGTGTTGAACGAGATTGCGAATGTCACGCGGCGGAAGTTCAGGATGA
GCTGGGCGCAGAGCGATGAATTTCTACTCATGCTCCGTGAGTTCGTGACCGTCGAGCCGCTGACCTATGAGACGCATGAT
CTGGGCATCGCCCTGGCGCGGAAGCACGCGCTGTCTGTCTATGACGCGATGATCGTCGCGGCCGGGCTGATGGCGGGATG
CGACACCGTGCTTTCCGAGGACATGCAGGACGGGTTCAGGGTGGCCGACAGGATCACGATCAGGAATCCCTTCGCCGCAT
GA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8725.98 Da        Isoelectric Point: 10.0780

>AT90329 WP_101754739.1 NZ_CP025432:99610-99840 [Paracoccus zhejiangensis]
MQIAKWGNSLAVRLPARMVQELGLKAGDEIEITAADAGHFQVHRHRDPEEILARLREFRGLMPKGYRFDRNEANAR

Download         Length: 231 bp

>AT90329 NZ_CP025432:99610-99840 [Paracoccus zhejiangensis]
ATGCAGATCGCGAAATGGGGCAATTCTCTGGCCGTCCGCCTGCCTGCGCGGATGGTCCAGGAGCTCGGGCTGAAGGCAGG
TGACGAGATCGAGATCACCGCGGCCGATGCCGGGCATTTTCAGGTTCATCGCCACCGCGATCCCGAAGAAATCCTGGCTC
GCCTGCGCGAGTTTCGCGGATTGATGCCCAAGGGCTATCGGTTCGACCGGAACGAGGCGAATGCCAGGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References