Detailed information of TA system TA090327

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-RelB
• Location: 14561..15122
• Replicon: plasmid pPZ02
• Accession: NZ_CP025432
• Organism: Paracoccus zhejiangensis strain J6

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: CX676_RS20555
• Protein ID: WP_101754680.1
• Coordinates: 14561..14836 (-)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: CX676_RS20560
• Protein ID: WP_101754681.1
• Coordinates: 14829..15122 (-)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CX676_RS20530	9630..10364	+	735	WP_101754839.1	MmgE/PrpD family protein	-
CX676_RS20535	10325..11539	-	1215	WP_101754676.1	IS256 family transposase	-
CX676_RS20540	11526..12296	+	771	WP_157936023.1	MmgE/PrpD family protein	-
CX676_RS20545	12275..13351	-	1077	WP_101754678.1	NAD/NADP-dependent octopine/nopaline dehydrogenase family protein	-
CX676_RS20550	13754..14419	+	666	WP_101754679.1	recombinase family protein	-
CX676_RS20555	14561..14836	-	276	WP_101754680.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
CX676_RS20560	14829..15122	-	294	WP_101754681.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
CX676_RS20565	15376..15702	-	327	WP_040546036.1	YnfA family protein	-
CX676_RS20570	15759..17111	-	1353	WP_007803574.1	NAD(P)/FAD-dependent oxidoreductase	-
CX676_RS20575	17134..18582	-	1449	WP_007803573.1	mercury(II) reductase	-
CX676_RS22655	18566..18703	-	138	WP_007803572.1	hypothetical protein	-
CX676_RS20580	18700..19086	-	387	WP_101754682.1	mercury resistance system transport protein MerF	-
CX676_RS22660	19083..19334	-	252	WP_072629817.1	hypothetical protein	-
CX676_RS20585	19365..19667	-	303	WP_040545980.1	hypothetical protein	-
CX676_RS20590	19683..20090	-	408	WP_007803565.1	mercury transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..214101	214101

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-90)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (4-56)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10015.69 Da
• Isoelectric Point: 6.4556

>T90327 WP_101754680.1 NZ_CP025432:c14836-14561 [Paracoccus zhejiangensis]
VPELEWKAPAVADLMAIVDYISDDNPDAALALMEEIQGKVAQLPAHPKRCRPGRVKGTRELVVRPNYIVVYAETAAAVTV
LRVLHAAQMWP

Nucleotide

• Length: 276 bp

>T90327 NZ_CP025432:c14836-14561 [Paracoccus zhejiangensis]
GTGCCTGAACTCGAATGGAAGGCCCCGGCGGTGGCGGATCTGATGGCGATTGTCGATTACATCTCGGACGACAACCCAGA
TGCGGCCCTTGCCCTGATGGAGGAGATTCAGGGCAAGGTGGCACAGCTTCCAGCGCATCCAAAACGCTGCCGCCCCGGCA
GAGTAAAGGGGACACGAGAGCTGGTGGTCCGGCCCAACTACATCGTTGTCTACGCCGAAACAGCAGCGGCGGTGACGGTG
CTGCGAGTGCTTCACGCCGCGCAGATGTGGCCATGA

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 10376.82 Da
• Isoelectric Point: 6.4608

>AT90327 WP_101754681.1 NZ_CP025432:c15122-14829 [Paracoccus zhejiangensis]
MPAQTSMLHVRVDDQLKAQATDALSGVGLTLSDAVRILLTRVAAEGGLPAGLTTDPAAYDTWFRAKVQEALADPRPATPH
DQVMQEARALIDGKRRA

Nucleotide

• Length: 294 bp

>AT90327 NZ_CP025432:c15122-14829 [Paracoccus zhejiangensis]
ATGCCCGCCCAAACCTCGATGCTCCATGTCCGCGTAGACGACCAGCTCAAGGCACAAGCAACCGACGCCCTGTCCGGCGT
CGGCCTGACGCTCTCAGACGCCGTGCGCATCCTGCTGACCCGGGTCGCTGCCGAGGGAGGCCTGCCCGCCGGTCTGACCA
CGGACCCAGCTGCCTATGACACTTGGTTCCGCGCCAAGGTTCAGGAAGCCTTGGCCGATCCCCGCCCGGCCACACCGCAT
GACCAAGTGATGCAGGAGGCGCGAGCCCTGATCGACGGGAAGCGCCGTGCCTGA