Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1543999..1544673 Replicon chromosome
Accession NZ_CP025419
Organism Streptococcus suis strain SH0104

Toxin (Protein)


Gene name hicA Uniprot ID A0A123U128
Locus tag CRH08_RS07995 Protein ID WP_009910449.1
Coordinates 1544491..1544673 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A7Y6VEQ2
Locus tag CRH08_RS07990 Protein ID WP_009910448.1
Coordinates 1543999..1544451 (-) Length 151 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CRH08_RS07960 1539994..1540998 + 1005 WP_009910438.1 lactonase family protein -
CRH08_RS07965 1541062..1541247 + 186 WP_002935693.1 hypothetical protein -
CRH08_RS07970 1541280..1541921 - 642 WP_002935700.1 HAD family hydrolase -
CRH08_RS07975 1542088..1542348 - 261 WP_009910443.1 type II toxin-antitoxin system RelE/ParE family toxin -
CRH08_RS07980 1542350..1542571 - 222 WP_012775256.1 hypothetical protein -
CRH08_RS07985 1543678..1543887 - 210 WP_009910447.1 hypothetical protein -
CRH08_RS07990 1543999..1544451 - 453 WP_009910448.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
CRH08_RS07995 1544491..1544673 - 183 WP_009910449.1 type II toxin-antitoxin system HicA family toxin Toxin
CRH08_RS08000 1544857..1545243 - 387 WP_009910450.1 hypothetical protein -
CRH08_RS08005 1545383..1545883 - 501 WP_024409209.1 hypothetical protein -
CRH08_RS08010 1545953..1546393 - 441 WP_024409208.1 hypothetical protein -
CRH08_RS08015 1546861..1547706 - 846 WP_024409207.1 ATP-binding protein -
CRH08_RS08020 1547722..1548516 - 795 WP_079269917.1 DnaD domain protein -
CRH08_RS08025 1548530..1548745 - 216 WP_024409205.1 hypothetical protein -
CRH08_RS11675 1548750..1548908 - 159 WP_162841287.1 hypothetical protein -
CRH08_RS08030 1548919..1549185 - 267 WP_024409204.1 hypothetical protein -
CRH08_RS08035 1549196..1549399 - 204 WP_024409203.1 hypothetical protein -
CRH08_RS08040 1549392..1549595 - 204 WP_024409202.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1541280..1552177 10897


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(17-82)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6681.93 Da        Isoelectric Point: 10.8207

>T90317 WP_009910449.1 NZ_CP025419:c1544673-1544491 [Streptococcus suis]
MPMTQKEMVKLLTAHGWTKTKGGKGSHVKLEKVGERPITIPHGEINKYTERGIKKQAGLL

Download         Length: 183 bp

>T90317 NZ_CP025419:c1544673-1544491 [Streptococcus suis]
ATGCCTATGACACAAAAAGAAATGGTTAAGCTACTTACCGCCCATGGTTGGACAAAAACTAAAGGTGGTAAGGGGTCTCA
CGTTAAACTTGAAAAAGTAGGCGAGCGACCTATAACCATTCCCCACGGTGAAATTAACAAATACACCGAAAGGGGTATCA
AAAAGCAAGCAGGGCTGTTATAA

Antitoxin


Download         Length: 151 a.a.        Molecular weight: 16672.68 Da        Isoelectric Point: 4.0098

>AT90317 WP_009910448.1 NZ_CP025419:c1544451-1543999 [Streptococcus suis]
MLVTYPALFYYDDTDGATAPYFVTFPDFEHSATQGEDMADAMAMASDWLGIHLADYIENGRDIPTPTPINALSLADNNPF
RDDKDIELVYDPSKSFVSMVMVDVAEYLGSQEPVKKTLTIPRWADTLGRELGLNFSQTLTDAIADKKIHA

Download         Length: 453 bp

>AT90317 NZ_CP025419:c1544451-1543999 [Streptococcus suis]
ATGCTTGTCACTTATCCAGCTTTATTTTATTATGACGATACAGACGGAGCTACCGCCCCTTATTTTGTCACTTTCCCAGA
CTTTGAACATTCAGCAACTCAGGGCGAAGATATGGCAGACGCTATGGCAATGGCTAGTGATTGGTTAGGTATTCATCTAG
CTGATTATATTGAGAATGGGCGTGATATTCCCACTCCTACCCCTATTAACGCTTTATCATTGGCTGATAATAACCCTTTC
CGTGATGATAAGGACATAGAGCTAGTTTATGACCCTAGCAAGTCTTTTGTATCTATGGTTATGGTTGACGTTGCTGAGTA
TCTAGGCAGTCAAGAGCCTGTAAAGAAAACACTAACTATTCCACGTTGGGCGGATACTTTAGGGCGTGAGTTAGGGCTAA
ATTTCTCACAGACCTTAACAGACGCTATTGCAGATAAGAAAATTCATGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A123U128

Antitoxin

Source ID Structure
AlphaFold DB A0A7Y6VEQ2

References