Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1542088..1542571 Replicon chromosome
Accession NZ_CP025419
Organism Streptococcus suis strain SH0104

Toxin (Protein)


Gene name relE Uniprot ID A0A0Z8BIZ7
Locus tag CRH08_RS07975 Protein ID WP_009910443.1
Coordinates 1542088..1542348 (-) Length 87 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0Z8BIX7
Locus tag CRH08_RS07980 Protein ID WP_012775256.1
Coordinates 1542350..1542571 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CRH08_RS07950 1537473..1538702 - 1230 WP_009910437.1 tetratricopeptide repeat protein -
CRH08_RS07955 1538692..1539858 - 1167 WP_002935690.1 AI-2E family transporter -
CRH08_RS07960 1539994..1540998 + 1005 WP_009910438.1 lactonase family protein -
CRH08_RS07965 1541062..1541247 + 186 WP_002935693.1 hypothetical protein -
CRH08_RS07970 1541280..1541921 - 642 WP_002935700.1 HAD family hydrolase -
CRH08_RS07975 1542088..1542348 - 261 WP_009910443.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CRH08_RS07980 1542350..1542571 - 222 WP_012775256.1 hypothetical protein Antitoxin
CRH08_RS07985 1543678..1543887 - 210 WP_009910447.1 hypothetical protein -
CRH08_RS07990 1543999..1544451 - 453 WP_009910448.1 type II toxin-antitoxin system HicB family antitoxin -
CRH08_RS07995 1544491..1544673 - 183 WP_009910449.1 type II toxin-antitoxin system HicA family toxin -
CRH08_RS08000 1544857..1545243 - 387 WP_009910450.1 hypothetical protein -
CRH08_RS08005 1545383..1545883 - 501 WP_024409209.1 hypothetical protein -
CRH08_RS08010 1545953..1546393 - 441 WP_024409208.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1541280..1552177 10897


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-86)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10270.78 Da        Isoelectric Point: 9.6925

>T90316 WP_009910443.1 NZ_CP025419:c1542348-1542088 [Streptococcus suis]
MYHLEYSKKAQKQIKKLDRQIQRLLFAWIDKHLEGTDNPRANGKGLTGNHANEWRYRIGDYRLICDIQDDKLVILALEFG
HRKDVY

Download         Length: 261 bp

>T90316 NZ_CP025419:c1542348-1542088 [Streptococcus suis]
ATGTATCATTTAGAGTATTCTAAAAAGGCTCAAAAGCAAATTAAGAAATTAGATAGGCAAATTCAGAGGTTGTTGTTTGC
TTGGATTGATAAACACTTAGAAGGGACTGATAATCCACGCGCCAATGGTAAAGGTTTGACAGGCAATCATGCTAACGAGT
GGCGTTATCGTATCGGAGATTACCGACTGATTTGCGATATTCAAGATGATAAGTTGGTTATTTTAGCACTTGAGTTTGGA
CATCGTAAAGATGTCTATTGA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8566.55 Da        Isoelectric Point: 4.4791

>AT90316 WP_012775256.1 NZ_CP025419:c1542571-1542350 [Streptococcus suis]
MSTVTIRLNQEEEVFFKSYAQLTGQSLSSLFKKALERDIEDEYDLKIYHQAYDEYKADPETISHADFKKELGL

Download         Length: 222 bp

>AT90316 NZ_CP025419:c1542571-1542350 [Streptococcus suis]
ATGAGTACAGTGACAATCAGATTAAATCAAGAAGAAGAAGTATTCTTTAAAAGCTATGCACAATTAACAGGTCAAAGTCT
TTCTAGCCTTTTTAAGAAAGCTTTGGAGCGTGATATTGAAGATGAGTATGATTTAAAAATCTATCATCAAGCTTATGATG
AGTACAAAGCAGATCCAGAAACAATTAGTCATGCTGATTTTAAGAAAGAGCTAGGATTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Z8BIZ7

Antitoxin

Source ID Structure
AlphaFold DB A0A0Z8BIX7

References