Detailed information of TA system TA090315

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): sezT-pezT/zeta-couple_hipB
• Location: 1126298..1127568
• Replicon: chromosome
• Accession: NZ_CP025419
• Organism: Streptococcus suis strain SH0104

Toxin (Protein)

• Gene name: sezT
• Uniprot ID: A0A0Z8INM2
• Locus tag: CRH08_RS05830
• Protein ID: WP_024409332.1
• Coordinates: 1126298..1127092 (-)
• Length: 265 a.a.

Antitoxin (Protein)

• Gene name: pezT
• Uniprot ID: -
• Locus tag: CRH08_RS05835
• Protein ID: WP_024409333.1
• Coordinates: 1127092..1127568 (-)
• Length: 159 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CRH08_RS05805	1121326..1123251	-	1926	WP_024409328.1	ATP-dependent helicase	-
CRH08_RS05810	1123248..1125071	-	1824	Protein_1076	AAA family ATPase	-
CRH08_RS05815	1125079..1126023	-	945	WP_024409330.1	IS30 family transposase	-
CRH08_RS05825	1126114..1126317	-	204	Protein_1078	AAA family ATPase	-
CRH08_RS05830	1126298..1127092	-	795	WP_024409332.1	zeta toxin family protein	Toxin
CRH08_RS05835	1127092..1127568	-	477	WP_024409333.1	helix-turn-helix domain-containing protein	Antitoxin
CRH08_RS05840	1127638..1127922	-	285	WP_024409334.1	hypothetical protein	-
CRH08_RS05845	1127966..1128361	-	396	WP_017285409.1	hypothetical protein	-
CRH08_RS05850	1128365..1128592	-	228	WP_024409335.1	hypothetical protein	-
CRH08_RS05855	1128646..1129734	-	1089	WP_024409336.1	toprim domain-containing protein	-
CRH08_RS05860	1129774..1130412	-	639	WP_024409337.1	hypothetical protein	-
CRH08_RS05865	1130523..1130813	-	291	WP_024409338.1	hypothetical protein	-
CRH08_RS05870	1130828..1131127	-	300	WP_024382151.1	hypothetical protein	-
CRH08_RS05875	1131197..1132108	-	912	WP_032505215.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	tet(O)	-	1105334..1166349	61015

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Zeta toxin domain (26-215)

Antitoxin

• Cro/C1-type helix-turn-helix domain (3-60)

Sequences

Toxin

Protein

• Length: 265 a.a.
• Molecular weight: 30360.57 Da
• Isoelectric Point: 6.6151

>T90315 WP_024409332.1 NZ_CP025419:c1127092-1126298 [Streptococcus suis]
MRLEEFSKDDFDLALKRTIRSLTRGKTTSVTPKAILLGGQSGAGKTTIHRIKQKEFQGNIIIIDGDSYRSLHPNYLTLQE
EYGKDSVDYTKGFAGKMVEQLVDELSKQGYHLLIEGTLRTTEVPRKTARLLKARGYQVSLALIATKPELSYLSTLIRYEE
VYVVNPNQARATPKEHHDGIVNHLVDNLRELENDHLFDYIQIYQRDRSCVYDSETDDGSAAEVLQECLFGKWSKVEEEMM
KMGQELLMEFLEMKKGRIYENKKN

Nucleotide

• Length: 795 bp

>T90315 NZ_CP025419:c1127092-1126298 [Streptococcus suis]
ATGCGGTTAGAAGAATTTAGCAAAGATGACTTTGACTTAGCCTTAAAACGAACTATTCGTTCCTTAACTCGTGGTAAAAC
GACATCAGTTACCCCAAAAGCCATCTTACTTGGTGGGCAAAGTGGAGCAGGAAAAACAACGATACACCGTATCAAGCAGA
AAGAGTTCCAAGGTAATATTATCATTATTGACGGTGATAGCTACCGCTCTTTACACCCGAATTATCTAACTTTACAAGAA
GAGTACGGGAAGGATAGCGTGGATTATACCAAAGGTTTTGCAGGAAAAATGGTGGAACAGCTTGTGGATGAACTCAGTAA
ACAAGGTTATCATTTGTTAATCGAAGGAACTTTGAGAACGACAGAAGTCCCACGAAAAACAGCACGGCTATTGAAAGCGA
GAGGTTATCAAGTCTCATTAGCTTTGATAGCAACCAAGCCTGAATTGTCTTATCTCAGCACCTTAATCCGCTACGAAGAA
GTCTATGTGGTTAATCCAAACCAAGCTAGAGCAACTCCTAAAGAACATCATGATGGAATTGTCAATCACTTGGTTGATAA
CTTACGAGAGCTAGAAAACGACCATCTCTTTGATTATATTCAAATTTATCAAAGAGATAGAAGTTGTGTTTATGATTCGG
AAACTGATGACGGTTCAGCAGCAGAAGTGCTACAAGAATGCCTCTTCGGAAAATGGAGCAAGGTGGAGGAAGAGATGATG
AAGATGGGACAGGAATTGTTGATGGAGTTTTTGGAAATGAAAAAAGGTAGAATTTATGAAAATAAAAAAAATTAA

Antitoxin

Protein

• Length: 159 a.a.
• Molecular weight: 18119.46 Da
• Isoelectric Point: 4.3193

>AT90315 WP_024409333.1 NZ_CP025419:c1127568-1127092 [Streptococcus suis]
MIGDNIKSLRKTHDLTQPEFAKIVGISRNSLSRYENGTSSLSTELIDRICQKFNVSYVDIVGEEKMLTPVEDYQLTLKIE
VIKERGAAILSELYRYQDSQGITFDDETSPWILMSDDLSDLINTKIYLVNTFDEVERYNGYLDGIERMLELANHQVVA

Nucleotide

• Length: 477 bp

>AT90315 NZ_CP025419:c1127568-1127092 [Streptococcus suis]
ATGATTGGAGATAATATTAAATCGTTACGTAAAACCCATGATTTAACACAACCAGAATTCGCAAAGATTGTTGGAATTTC
TCGAAATAGTTTGAGCCGTTATGAAAATGGGACAAGCTCGTTATCAACAGAGCTCATAGACCGTATCTGTCAGAAATTTA
ATGTATCATATGTTGATATTGTAGGAGAAGAAAAAATGTTAACACCAGTGGAAGATTATCAATTAACCTTAAAAATTGAA
GTTATCAAAGAGCGTGGCGCAGCGATTTTGTCCGAACTATATCGCTATCAAGATAGTCAAGGAATTACTTTTGATGATGA
GACTAGCCCTTGGATTTTGATGAGTGATGATTTGTCTGATCTTATCAATACCAAGATTTACCTTGTCAATACTTTTGATG
AAGTGGAGCGTTACAATGGTTATTTAGATGGTATTGAGCGAATGTTGGAGCTTGCTAATCATCAGGTGGTGGCTTAA

Structures

Toxin

• AlphaFold DB: A0A0Z8INM2