Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-Phd
Location 24004..24662 Replicon plasmid pBM151
Accession NZ_CP025409
Organism Paracoccus sp. BM15

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag CUV01_RS18605 Protein ID WP_101462244.1
Coordinates 24004..24405 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag CUV01_RS18610 Protein ID WP_101462245.1
Coordinates 24405..24662 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CUV01_RS18570 19879..20118 + 240 WP_101462238.1 hypothetical protein -
CUV01_RS18575 20105..20305 + 201 WP_101462239.1 hypothetical protein -
CUV01_RS18580 20302..21195 + 894 WP_101462240.1 DUF1738 domain-containing protein -
CUV01_RS19755 21192..21377 + 186 WP_143795280.1 hypothetical protein -
CUV01_RS19760 21484..21768 + 285 WP_157994914.1 hypothetical protein -
CUV01_RS18590 21768..22145 + 378 WP_101462242.1 winged helix-turn-helix domain-containing protein -
CUV01_RS19765 22142..22612 - 471 WP_157994915.1 hypothetical protein -
CUV01_RS18600 22826..23848 - 1023 WP_157994916.1 DUF1403 family protein -
CUV01_RS18605 24004..24405 - 402 WP_101462244.1 type II toxin-antitoxin system VapC family toxin Toxin
CUV01_RS18610 24405..24662 - 258 WP_101462245.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
CUV01_RS18615 24714..25751 + 1038 WP_101462246.1 tyrosine-type recombinase/integrase -
CUV01_RS18620 26039..27226 + 1188 WP_101462310.1 plasmid partitioning protein RepA -
CUV01_RS18625 27226..28140 + 915 WP_101462247.1 plasmid partitioning protein RepB -
CUV01_RS18630 28327..29490 + 1164 WP_101462248.1 replication initiation protein RepC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..92522 92522
- flank IS/Tn - - 18748..19464 716


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-119)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-49)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14413.37 Da        Isoelectric Point: 4.8668

>T90311 WP_101462244.1 NZ_CP025409:c24405-24004 [Paracoccus sp. BM15]
MYLLDTNVISAVRRPDRAPQVAAWLADKAEAELFLSVITLGEIERGIHQQASRNAGFAADLRAWLDRTLRLFGDRLLPFG
PEDARIWGRLSQEIGHDGADLMIAATALARGATVVTGNTADFAPTGVALENPF

Download         Length: 402 bp

>T90311 NZ_CP025409:c24405-24004 [Paracoccus sp. BM15]
ATGTACCTGCTCGATACCAATGTCATCTCGGCGGTGCGCCGGCCGGACCGCGCGCCGCAGGTGGCGGCCTGGCTGGCCGA
CAAAGCCGAAGCCGAGCTGTTTCTCTCGGTCATCACGCTTGGCGAGATCGAGCGTGGGATCCATCAGCAGGCGTCCCGCA
ATGCCGGCTTTGCCGCCGACCTGCGCGCCTGGCTGGACCGGACCCTGCGGCTCTTCGGCGATCGGCTGCTGCCCTTCGGA
CCTGAGGATGCGCGTATTTGGGGCCGCCTCAGCCAGGAGATCGGCCATGACGGCGCCGACCTGATGATTGCAGCCACGGC
GCTCGCACGGGGCGCCACGGTCGTCACCGGCAACACCGCCGATTTTGCGCCCACCGGGGTGGCGCTGGAAAACCCGTTCT
GA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9562.79 Da        Isoelectric Point: 7.0136

>AT90311 WP_101462245.1 NZ_CP025409:c24662-24405 [Paracoccus sp. BM15]
MWTLQDAKNRFSAVVDAALAGQPQQVSRRGKPAVVVMAAEEYRRLLDSAREERGSFVAHLMAFPDDGSDEFDLPRGRVTP
RDVRF

Download         Length: 258 bp

>AT90311 NZ_CP025409:c24662-24405 [Paracoccus sp. BM15]
ATGTGGACCCTGCAGGATGCCAAGAATCGCTTCAGCGCCGTGGTGGATGCGGCCCTGGCCGGCCAGCCGCAACAGGTCAG
CCGGCGCGGCAAGCCGGCCGTGGTGGTGATGGCGGCGGAGGAATACCGGCGGCTTCTCGACAGCGCCCGAGAGGAGCGCG
GCAGTTTTGTCGCACATCTGATGGCCTTTCCGGATGACGGCAGCGACGAGTTCGACCTGCCGCGAGGCCGGGTGACACCG
CGTGATGTCCGTTTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References