Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4824650..4825485 Replicon chromosome
Accession NZ_CP025401
Organism Escherichia coli strain MS8345

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag MS8345_RS25205 Protein ID WP_023180999.1
Coordinates 4824650..4825027 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag MS8345_RS25210 Protein ID WP_001285113.1
Coordinates 4825117..4825485 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MS8345_RS25175 4820618..4821883 - 1266 WP_001218869.1 integrase arm-type DNA-binding domain-containing protein -
MS8345_RS25180 4822347..4822673 - 327 WP_000779483.1 type II toxin-antitoxin system RelE/ParE family toxin -
MS8345_RS25185 4822670..4822933 - 264 WP_001143297.1 type II toxin-antitoxin system ParD family antitoxin -
MS8345_RS25190 4823005..4823871 - 867 WP_021547704.1 DUF4942 domain-containing protein -
MS8345_RS25195 4823956..4824153 - 198 WP_000839240.1 DUF957 domain-containing protein -
MS8345_RS25200 4824165..4824653 - 489 WP_000761678.1 hypothetical protein -
MS8345_RS25205 4824650..4825027 - 378 WP_023180999.1 TA system toxin CbtA family protein Toxin
MS8345_RS25210 4825117..4825485 - 369 WP_001285113.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
MS8345_RS25215 4825535..4826179 - 645 WP_000086770.1 hypothetical protein -
MS8345_RS25220 4826198..4826419 - 222 WP_000692345.1 DUF987 domain-containing protein -
MS8345_RS25225 4826488..4826964 - 477 WP_001186715.1 RadC family protein -
MS8345_RS25235 4826980..4827465 - 486 WP_000213705.1 antirestriction protein -
MS8345_RS25240 4827541..4828359 - 819 WP_001175145.1 DUF945 domain-containing protein -
MS8345_RS25245 4828449..4828682 - 234 WP_001278282.1 DUF905 family protein -
MS8345_RS25250 4828688..4829365 - 678 WP_001097369.1 hypothetical protein -
MS8345_RS25255 4829513..4830193 - 681 Protein_4634 WYL domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island erm(B) / ant(3'')-Ia / sul1 papX 4817125..4871711 54586


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14103.15 Da        Isoelectric Point: 8.2905

>T90301 WP_023180999.1 NZ_CP025401:c4825027-4824650 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCTRSQLINSIDILRARRATGLMARENYRTVNNITLGKHPGAKQ

Download         Length: 378 bp

>T90301 NZ_CP025401:c4825027-4824650 [Escherichia coli]
ATGAAAACATTACCCGACACGCATGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTACGGCCTTACGCTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCACTGGTACGAACCGACCAGCCGGGGTTC
AGCACCTGTACCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCCCGCCGGGCAACCGGCCTGATGGCCCGCGA
AAATTACAGAACGGTAAATAACATTACCCTGGGTAAACATCCGGGGGCGAAACAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13693.33 Da        Isoelectric Point: 5.4970

>AT90301 WP_001285113.1 NZ_CP025401:c4825485-4825117 [Escherichia coli]
VSDSLHETNYPDDNNDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELSPRHQHTVTLYARGLTCEADTLGSCGYVYLAVYPTSETKT

Download         Length: 369 bp

>AT90301 NZ_CP025401:c4825485-4825117 [Escherichia coli]
GTGTCAGACTCACTCCATGAAACAAATTATCCCGACGATAACAACGACCGCCCCTGGTGGGGGCTACCCTGCACCGTGAC
GCCCTGTTTTGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTCAGCCCCCGCCATCAGCATACCGTCACGCTGTATGCCAGAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGCTG
TGGTTACGTTTATCTGGCTGTTTATCCAACATCCGAAACGAAAACGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References