Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3308163..3308998 Replicon chromosome
Accession NZ_CP025401
Organism Escherichia coli strain MS8345

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag MS8345_RS17345 Protein ID WP_023180999.1
Coordinates 3308621..3308998 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag MS8345_RS17340 Protein ID WP_001285113.1
Coordinates 3308163..3308531 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MS8345_RS17290 3303456..3304136 + 681 Protein_3198 WYL domain-containing protein -
MS8345_RS17295 3304284..3304961 + 678 WP_001097369.1 hypothetical protein -
MS8345_RS17300 3304967..3305200 + 234 WP_001278282.1 DUF905 family protein -
MS8345_RS17310 3305290..3306106 + 817 Protein_3201 DUF932 domain-containing protein -
MS8345_RS17315 3306183..3306668 + 486 WP_000213705.1 antirestriction protein -
MS8345_RS17325 3306684..3307160 + 477 WP_001186715.1 RadC family protein -
MS8345_RS17330 3307229..3307450 + 222 WP_000692345.1 DUF987 domain-containing protein -
MS8345_RS17335 3307469..3308113 + 645 WP_000086770.1 hypothetical protein -
MS8345_RS17340 3308163..3308531 + 369 WP_001285113.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
MS8345_RS17345 3308621..3308998 + 378 WP_023180999.1 TA system toxin CbtA family protein Toxin
MS8345_RS17350 3308995..3309483 + 489 WP_000761678.1 hypothetical protein -
MS8345_RS17355 3309495..3309692 + 198 WP_000839240.1 DUF957 domain-containing protein -
MS8345_RS17360 3309777..3310642 + 866 Protein_3210 DUF4942 domain-containing protein -
MS8345_RS17365 3310714..3310977 + 264 WP_001143297.1 type II toxin-antitoxin system ParD family antitoxin -
MS8345_RS17370 3310974..3311300 + 327 WP_000779483.1 type II toxin-antitoxin system RelE/ParE family toxin -
MS8345_RS17375 3311763..3313025 + 1263 WP_001218820.1 integrase arm-type DNA-binding domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - papG / papF / papE / papK / papJ / papD / papC / papH / papA / papB / papI / kpsF / kpsE / kpsD / kpsU / kpsC / kpsS / neuE / neuC / neuA / neuB / neuD / kpsT / kpsM / gspM / gspL / gspK / gspJ / gspI / gspH / gspG / gspF / gspE / gspD / gspC 3289303..3461612 172309


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14103.15 Da        Isoelectric Point: 8.2905

>T90289 WP_023180999.1 NZ_CP025401:3308621-3308998 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCTRSQLINSIDILRARRATGLMARENYRTVNNITLGKHPGAKQ

Download         Length: 378 bp

>T90289 NZ_CP025401:3308621-3308998 [Escherichia coli]
ATGAAAACATTACCCGACACGCATGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTACGGCCTTACGCTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCACTGGTACGAACCGACCAGCCGGGGTTC
AGCACCTGTACCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCCCGCCGGGCAACCGGCCTGATGGCCCGCGA
AAATTACAGAACGGTAAATAACATTACCCTGGGTAAACATCCGGGGGCGAAACAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13693.33 Da        Isoelectric Point: 5.4970

>AT90289 WP_001285113.1 NZ_CP025401:3308163-3308531 [Escherichia coli]
VSDSLHETNYPDDNNDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELSPRHQHTVTLYARGLTCEADTLGSCGYVYLAVYPTSETKT

Download         Length: 369 bp

>AT90289 NZ_CP025401:3308163-3308531 [Escherichia coli]
GTGTCAGACTCACTCCATGAAACAAATTATCCCGACGATAACAACGACCGCCCCTGGTGGGGGCTACCCTGCACCGTGAC
GCCCTGTTTTGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTCAGCCCCCGCCATCAGCATACCGTCACGCTGTATGCCAGAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGCTG
TGGTTACGTTTATCTGGCTGTTTATCCAACATCCGAAACGAAAACGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References