Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 2058650..2059118 Replicon chromosome
Accession NZ_CP025396
Organism Staphylococcus haemolyticus strain B

Toxin (Protein)


Gene name TsaT Uniprot ID Q4L4Q4
Locus tag CYD28_RS09960 Protein ID WP_011276326.1
Coordinates 2058930..2059118 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID Q4L4Q5
Locus tag CYD28_RS09955 Protein ID WP_011276325.1
Coordinates 2058650..2058907 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CYD28_RS09920 2053826..2054551 - 726 WP_033079650.1 type I 3-dehydroquinate dehydratase -
CYD28_RS09925 2054714..2055136 + 423 WP_016931015.1 organic hydroperoxide resistance protein -
CYD28_RS09930 2055399..2055890 + 492 WP_049395890.1 GNAT family N-acetyltransferase -
CYD28_RS09935 2056022..2056639 + 618 WP_033079648.1 LysE/ArgO family amino acid transporter -
CYD28_RS09940 2056826..2057434 - 609 WP_011276323.1 phosphoglycerate mutase family protein -
CYD28_RS09945 2057662..2057904 + 243 WP_011276324.1 hypothetical protein -
CYD28_RS09950 2057896..2058099 - 204 WP_033079647.1 sterile alpha motif-like domain-containing protein -
CYD28_RS09955 2058650..2058907 + 258 WP_011276325.1 hypothetical protein Antitoxin
CYD28_RS09960 2058930..2059118 + 189 WP_011276326.1 hypothetical protein Toxin
CYD28_RS09965 2059236..2059817 + 582 WP_033079646.1 orthopoxovirus protein, PF05708 family -
CYD28_RS09970 2059865..2060101 - 237 WP_016931008.1 hypothetical protein -
CYD28_RS09975 2060271..2061017 + 747 WP_033079645.1 membrane lipoprotein lipid attachment site-containing protein -
CYD28_RS09980 2061086..2061694 - 609 WP_033079644.1 GNAT family N-acetyltransferase -
CYD28_RS09985 2061831..2062577 + 747 WP_033079643.1 poly-gamma-glutamate hydrolase family protein -
CYD28_RS09990 2062653..2062940 + 288 WP_033079642.1 hypothetical protein -
CYD28_RS09995 2063184..2063408 + 225 WP_033079641.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(22-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(85-138)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7110.80 Da        Isoelectric Point: 9.6269

>T90264 WP_011276326.1 NZ_CP025396:2058930-2059118 [Staphylococcus haemolyticus]
MSLHLTILLWLGIIFVIAASIILGLLLKSKKEERKESYLGFTVIFYIFGFALLIYVFIFGIL

Download         Length: 189 bp

>T90264 NZ_CP025396:2058930-2059118 [Staphylococcus haemolyticus]
ATGAGTTTGCATTTAACTATATTGTTATGGCTTGGTATCATTTTTGTAATAGCAGCCTCAATTATATTGGGCTTATTACT
TAAATCTAAAAAAGAAGAACGTAAAGAATCATATTTAGGTTTTACCGTAATATTTTATATTTTTGGATTTGCTTTACTCA
TCTACGTATTCATATTTGGTATATTATAG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9914.97 Da        Isoelectric Point: 4.0625

>AT90264 WP_011276325.1 NZ_CP025396:2058650-2058907 [Staphylococcus haemolyticus]
MNNNKIFWINIFMTLLFLGFNIIVTYNADLDDFFWLIPGLTISGITIVLSLSTALICKNLVSEVIFLINIVMLLYYIYPM
VYTFF

Download         Length: 258 bp

>AT90264 NZ_CP025396:2058650-2058907 [Staphylococcus haemolyticus]
ATGAATAATAATAAAATTTTTTGGATAAATATTTTTATGACGCTATTATTTTTGGGTTTCAATATCATTGTCACTTACAA
TGCAGACTTAGATGATTTCTTCTGGCTAATTCCAGGACTGACAATTAGTGGTATCACAATTGTACTAAGCTTAAGTACTG
CGCTCATTTGCAAGAACCTGGTTAGCGAAGTTATTTTTCTAATCAATATTGTTATGCTTTTATACTACATTTATCCTATG
GTATATACATTCTTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A1KAB5

Antitoxin

Source ID Structure
AlphaFold DB A0A2A1KAX9

References