Detailed information of TA system TA090257

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsdAT/-
• Location: 2137214..2137728
• Replicon: chromosome
• Accession: NZ_CP025395
• Organism: Staphylococcus aureus O46

Toxin (Protein)

• Gene name: TsdT
• Uniprot ID: -
• Locus tag: SAO46_RS10930
• Protein ID: WP_000603099.1
• Coordinates: 2137214..2137423 (-)
• Length: 70 a.a.

Antitoxin (Protein)

• Gene name: TsdA
• Uniprot ID: -
• Locus tag: SAO46_RS10935
• Protein ID: WP_000138931.1
• Coordinates: 2137435..2137728 (-)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SAO46_RS10910	2132722..2134080	-	1359	WP_000611472.1	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase	-
SAO46_RS10915	2134095..2135165	-	1071	WP_000159631.1	D-alanine--D-alanine ligase	-
SAO46_RS10920	2135483..2136685	+	1203	WP_001109939.1	rod shape-determining protein RodA	-
SAO46_RS10925	2136949..2137086	-	138	WP_000828354.1	hypothetical protein	-
SAO46_RS10930	2137214..2137423	-	210	WP_000603099.1	heavy-metal-associated domain-containing protein	Toxin
SAO46_RS10935	2137435..2137728	-	294	WP_000138931.1	copper-sensing transcriptional repressor CsoR	Antitoxin
SAO46_RS10940	2137894..2139378	+	1485	WP_000571551.1	cardiolipin synthase	-
SAO46_RS10945	2139406..2140068	+	663	WP_001187618.1	HD domain-containing protein	-
SAO46_RS10960	2140818..2141690	-	873	WP_000725802.1	membrane protein insertase YidC	-
SAO46_RS10965	2141776..2142417	-	642	WP_000483158.1	thiamine phosphate synthase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Heavy metal-associated domain, HMA (23-66)

Antitoxin

• Metal-sensitive transcriptional repressor (3-95)

Sequences

Toxin

Protein

• Length: 70 a.a.
• Molecular weight: 7819.79 Da
• Isoelectric Point: 3.9389

>T90257 WP_000603099.1 NZ_CP025395:c2137423-2137214 [Staphylococcus aureus O46]
MILQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Nucleotide

• Length: 210 bp

>T90257 NZ_CP025395:c2137423-2137214 [Staphylococcus aureus O46]
ATGATACTTCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATAGATGGTCAAGTAACTGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 11199.84 Da
• Isoelectric Point: 6.7122

>AT90257 WP_000138931.1 NZ_CP025395:c2137728-2137435 [Staphylococcus aureus O46]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDIYCDDVLTQIRATRSALNSVATKLLEQHMKSCIMNKVNKGAQ
EEAMEELLVTFQKLIKD

Nucleotide

• Length: 294 bp

>AT90257 NZ_CP025395:c2137728-2137435 [Staphylococcus aureus O46]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATATCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGACAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATAAAGGTGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA