Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2137214..2137728 Replicon chromosome
Accession NZ_CP025395
Organism Staphylococcus aureus O46

Toxin (Protein)


Gene name TsdT Uniprot ID -
Locus tag SAO46_RS10930 Protein ID WP_000603099.1
Coordinates 2137214..2137423 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID -
Locus tag SAO46_RS10935 Protein ID WP_000138931.1
Coordinates 2137435..2137728 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SAO46_RS10910 2132722..2134080 - 1359 WP_000611472.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
SAO46_RS10915 2134095..2135165 - 1071 WP_000159631.1 D-alanine--D-alanine ligase -
SAO46_RS10920 2135483..2136685 + 1203 WP_001109939.1 rod shape-determining protein RodA -
SAO46_RS10925 2136949..2137086 - 138 WP_000828354.1 hypothetical protein -
SAO46_RS10930 2137214..2137423 - 210 WP_000603099.1 heavy-metal-associated domain-containing protein Toxin
SAO46_RS10935 2137435..2137728 - 294 WP_000138931.1 copper-sensing transcriptional repressor CsoR Antitoxin
SAO46_RS10940 2137894..2139378 + 1485 WP_000571551.1 cardiolipin synthase -
SAO46_RS10945 2139406..2140068 + 663 WP_001187618.1 HD domain-containing protein -
SAO46_RS10960 2140818..2141690 - 873 WP_000725802.1 membrane protein insertase YidC -
SAO46_RS10965 2141776..2142417 - 642 WP_000483158.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(3-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7819.79 Da        Isoelectric Point: 3.9389

>T90257 WP_000603099.1 NZ_CP025395:c2137423-2137214 [Staphylococcus aureus O46]
MILQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T90257 NZ_CP025395:c2137423-2137214 [Staphylococcus aureus O46]
ATGATACTTCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATAGATGGTCAAGTAACTGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11199.84 Da        Isoelectric Point: 6.7122

>AT90257 WP_000138931.1 NZ_CP025395:c2137728-2137435 [Staphylococcus aureus O46]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDIYCDDVLTQIRATRSALNSVATKLLEQHMKSCIMNKVNKGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT90257 NZ_CP025395:c2137728-2137435 [Staphylococcus aureus O46]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATATCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGACAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATAAAGGTGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References