Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 873989..874466 Replicon chromosome
Accession NZ_CP025395
Organism Staphylococcus aureus O46

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag SAO46_RS04395 Protein ID WP_000052076.1
Coordinates 873989..874177 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag SAO46_RS04400 Protein ID WP_001059690.1
Coordinates 874206..874466 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SAO46_RS04365 870029..870499 + 471 WP_000824473.1 hypothetical protein -
SAO46_RS04370 870840..871526 + 687 WP_000141556.1 thermonuclease family protein -
SAO46_RS04375 871883..872083 + 201 WP_001059082.1 cold-shock protein -
SAO46_RS04380 872580..872798 - 219 WP_000005883.1 hypothetical protein -
SAO46_RS04385 872860..873144 - 285 WP_001004401.1 hypothetical protein -
SAO46_RS04390 873232..873801 - 570 WP_001106647.1 hypothetical protein -
SAO46_RS04395 873989..874177 - 189 WP_000052076.1 hypothetical protein Toxin
SAO46_RS04400 874206..874466 - 261 WP_001059690.1 hypothetical protein Antitoxin
SAO46_RS04405 874807..875010 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
SAO46_RS04410 875007..875243 - 237 WP_000368687.1 hypothetical protein -
SAO46_RS04415 875468..876049 + 582 WP_001140691.1 phosphoglycerate mutase family protein -
SAO46_RS04420 876122..876739 - 618 WP_000255553.1 LysE/ArgO family amino acid transporter -
SAO46_RS04425 876896..877390 - 495 WP_000569881.1 GNAT family N-acetyltransferase -
SAO46_RS04430 877789..878211 - 423 WP_000974457.1 organic hydroperoxide resistance protein -
SAO46_RS04435 878359..879075 + 717 WP_000150028.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type I toxin-antitoxin system, toxin Ldr

(1-35)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T90252 WP_000052076.1 NZ_CP025395:c874177-873989 [Staphylococcus aureus O46]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T90252 NZ_CP025395:c874177-873989 [Staphylococcus aureus O46]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTCGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT90252 WP_001059690.1 NZ_CP025395:c874466-874206 [Staphylococcus aureus O46]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT90252 NZ_CP025395:c874466-874206 [Staphylococcus aureus O46]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References