Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TscAT/-
Location 422398..422936 Replicon chromosome
Accession NZ_CP025395
Organism Staphylococcus aureus O46

Toxin (Protein)


Gene name TscT Uniprot ID -
Locus tag SAO46_RS02040 Protein ID WP_001103963.1
Coordinates 422610..422936 (+) Length 109 a.a.

Antitoxin (Protein)


Gene name TscA Uniprot ID -
Locus tag SAO46_RS02035 Protein ID WP_001058493.1
Coordinates 422398..422607 (+) Length 70 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SAO46_RS01985 417447..417638 - 192 WP_001052483.1 hypothetical protein -
SAO46_RS01995 417882..418178 + 297 WP_001261460.1 30S ribosomal protein S6 -
SAO46_RS02000 418199..418702 + 504 WP_000934799.1 single-stranded DNA-binding protein -
SAO46_RS02005 418754..418996 + 243 WP_000897044.1 30S ribosomal protein S18 -
SAO46_RS02010 419237..420466 - 1230 WP_000270123.1 site-specific integrase -
SAO46_RS02015 420923..421618 - 696 WP_000668212.1 helix-turn-helix domain-containing protein -
SAO46_RS02020 421762..421974 + 213 WP_000794656.1 helix-turn-helix transcriptional regulator -
SAO46_RS02025 421975..422247 + 273 WP_000091734.1 helix-turn-helix domain-containing protein -
SAO46_RS02030 422259..422405 + 147 WP_031824147.1 hypothetical protein -
SAO46_RS02035 422398..422607 + 210 WP_001058493.1 hypothetical protein Antitoxin
SAO46_RS02040 422610..422936 + 327 WP_001103963.1 DUF1474 family protein Toxin
SAO46_RS02045 423001..423870 + 870 WP_001002726.1 primase alpha helix C-terminal domain-containing protein -
SAO46_RS02050 423884..425593 + 1710 WP_000447457.1 DUF927 domain-containing protein -
SAO46_RS02055 425905..426285 + 381 WP_000356937.1 hypothetical protein -
SAO46_RS02060 426282..426923 + 642 WP_001019787.1 hypothetical protein -
SAO46_RS02065 427270..427611 + 342 WP_001190600.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 418199..464324 46125


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1474

(1-100)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 109 a.a.        Molecular weight: 13092.50 Da        Isoelectric Point: 4.7172

>T90251 WP_001103963.1 NZ_CP025395:422610-422936 [Staphylococcus aureus O46]
MNWEIKSLFSDLELLKDSFKDLKDNHGWHFDKLYPHEPNHVLNKDELIREGFSYHERRIHNNQMFDLFHLYIEQFDNIIE
KFYEIEKASSENFGEESDDAKNSIKVAE

Download         Length: 327 bp

>T90251 NZ_CP025395:422610-422936 [Staphylococcus aureus O46]
ATGAATTGGGAAATTAAAAGTTTATTTAGCGATTTAGAGTTGTTGAAAGATAGTTTTAAGGATTTAAAGGATAATCATGG
TTGGCATTTTGATAAGTTATATCCTCATGAACCAAATCATGTCTTAAATAAAGATGAATTAATTAGAGAGGGTTTTTCTT
ATCATGAGAGACGTATTCACAATAATCAAATGTTTGATTTATTCCATCTCTATATAGAGCAGTTCGATAATATTATCGAA
AAGTTTTATGAAATAGAAAAAGCATCATCTGAGAACTTTGGCGAGGAATCAGATGACGCAAAGAATTCAATAAAAGTAGC
AGAGTAA

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 8152.19 Da        Isoelectric Point: 4.4665

>AT90251 WP_001058493.1 NZ_CP025395:422398-422607 [Staphylococcus aureus O46]
MNNEQKEVIEHVVYQLELSVMNNLESYEHTEYVNGIEVVSEVSREKHLELIMKWCAQELKNNFQLGKGE

Download         Length: 210 bp

>AT90251 NZ_CP025395:422398-422607 [Staphylococcus aureus O46]
ATGAATAATGAACAAAAAGAAGTAATAGAACACGTGGTTTATCAACTCGAGTTAAGTGTCATGAATAATTTGGAAAGTTA
TGAACACACAGAATATGTTAATGGTATTGAAGTGGTTTCAGAGGTTAGTCGTGAAAAGCACTTAGAATTGATAATGAAAT
GGTGCGCACAAGAATTAAAGAATAATTTTCAATTAGGAAAAGGAGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References