Detailed information of TA system TA090247

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-RelB
• Location: 2478388..2478927
• Replicon: chromosome
• Accession: NZ_CP025394
• Organism: Kitasatospora sp. MMS16-BH015

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: CFP65_RS10690
• Protein ID: WP_104815886.1
• Coordinates: 2478649..2478927 (+)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: CFP65_RS10685
• Protein ID: WP_174805632.1
• Coordinates: 2478388..2478645 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CFP65_RS10665	2474460..2475011	+	552	WP_104815881.1	flavoprotein	-
CFP65_RS10670	2475247..2476563	+	1317	WP_158702129.1	oligopeptide:H+ symporter	-
CFP65_RS10675	2476656..2477636	-	981	WP_104815883.1	YafY family transcriptional regulator	-
CFP65_RS10680	2477748..2478287	+	540	WP_104815884.1	DinB family protein	-
CFP65_RS10685	2478388..2478645	+	258	WP_174805632.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
CFP65_RS10690	2478649..2478927	+	279	WP_104815886.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
CFP65_RS10695	2478953..2480029	-	1077	WP_104815887.1	Zn-dependent alcohol dehydrogenase	-
CFP65_RS10700	2480276..2481628	+	1353	WP_104815888.1	M48 family metallopeptidase	-
CFP65_RS10705	2481773..2482426	+	654	WP_104815889.1	class I SAM-dependent methyltransferase	-
CFP65_RS10710	2482443..2483174	-	732	WP_104820773.1	nucleotidyltransferase domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-89)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (2-63)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10648.25 Da
• Isoelectric Point: 10.9485

>T90247 WP_104815886.1 NZ_CP025394:2478649-2478927 [Kitasatospora sp. MMS16-BH015]
MGYATRFTPHAQRDLLKIPRPDALRILRHLAELQQGLSSGDTTHLDIKTLQGHSARWRLRVGDYRVVYTVENGQLLVWVL
AVGNRRDVYRQL

Nucleotide

• Length: 279 bp

>T90247 NZ_CP025394:2478649-2478927 [Kitasatospora sp. MMS16-BH015]
ATGGGCTACGCGACCCGCTTCACCCCGCACGCCCAGCGCGACCTCCTCAAGATCCCCCGCCCGGACGCCCTACGCATCCT
GCGCCACCTCGCCGAGCTGCAGCAGGGATTGAGCAGCGGCGATACGACGCACCTCGACATCAAGACGCTCCAAGGCCACA
GTGCGCGCTGGCGCCTCAGGGTCGGGGACTACCGAGTCGTCTACACCGTCGAGAACGGTCAACTCCTGGTGTGGGTACTG
GCGGTCGGCAACAGGCGGGACGTCTACCGACAGCTGTGA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9566.61 Da
• Isoelectric Point: 4.2900

>AT90247 WP_174805632.1 NZ_CP025394:2478388-2478645 [Kitasatospora sp. MMS16-BH015]
MAEVRSHLADVLDRARREDTPTIITRRGKQEAVVIDIREYQRLSLLAEQAEEDWLNRLADEAESEGSEGSVSLEEMAAIL
RAQGT

Nucleotide

• Length: 258 bp

>AT90247 NZ_CP025394:2478388-2478645 [Kitasatospora sp. MMS16-BH015]
ATGGCCGAGGTCCGCAGCCATCTCGCCGACGTCCTCGACCGGGCCCGCCGCGAGGACACCCCGACGATCATCACGCGGCG
CGGCAAGCAGGAAGCCGTCGTGATCGACATTCGCGAGTACCAGCGCCTGAGCCTGCTGGCGGAGCAGGCCGAGGAGGACT
GGCTCAACAGGCTTGCGGACGAAGCCGAGTCCGAAGGCTCCGAGGGCTCGGTCTCCCTGGAGGAGATGGCCGCCATCCTC
CGCGCGCAGGGCACCTGA