Detailed information of TA system TA090124

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/-
• Location: 14581..14957
• Replicon: plasmid unnamed
• Accession: NZ_CP025329
• Organism: Escherichia coli strain ExPEC XM

Toxin (Protein)

• Gene name: parE
• Uniprot ID: A0A075MDK3
• Locus tag: CXG97_RS26830
• Protein ID: WP_000969988.1
• Coordinates: 14775..14957 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: CXG97_RS26825
• Protein ID: WP_001324224.1
• Coordinates: 14581..14778 (+)
• Length: 66 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CXG97_RS28810	9842..10078	+	237	WP_001323890.1	colicin V immunity protein	-
CXG97_RS26810	10056..10366	+	311	Protein_12	colicin V	-
CXG97_RS26815	10536..12650	-	2115	WP_001183603.1	peptidase domain-containing ABC transporter	-
CXG97_RS26820	12625..13899	-	1275	WP_000489608.1	HlyD family secretion protein	-
CXG97_RS26825	14581..14778	+	198	WP_001324224.1	toxin-antitoxin system protein	Antitoxin
CXG97_RS26830	14775..14957	+	183	WP_000969988.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
CXG97_RS26835	15056..15364	+	309	WP_000377483.1	hypothetical protein	-
CXG97_RS26845	15924..16958	+	1035	WP_001190233.1	3-deoxy-7-phosphoheptulonate synthase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Conjugative plasmid	sitABCD / aph(6)-Id / aph(3'')-Ib / tet(A)	vat / iroN / iroE / iroD / iroD / iroC / iroB / iucA / iucB / iucC / iucD / iutA	1..286854	286854

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Entericidin A/B (23-42)

Antitoxin

• Entericidin A/B (23-42)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6931.07 Da
• Isoelectric Point: 4.5349

>T90124 WP_000969988.1 NZ_CP025329:14775-14957 [Escherichia coli]
MMEIFWTMLASQDRKRIREYIAEQNLIAAIELDERIGCSASLLFSLSFISVQVHDNIITV

Nucleotide

• Length: 183 bp

>T90124 NZ_CP025329:14775-14957 [Escherichia coli]
ATGATGGAGATATTCTGGACCATGCTGGCCAGCCAGGACAGGAAGCGCATTCGTGAGTACATTGCGGAGCAGAACCTGAT
AGCCGCCATTGAACTGGACGAACGGATTGGTTGTTCAGCCAGCCTCCTGTTCTCCCTTTCTTTTATCAGTGTACAGGTGC
ATGACAACATAATCACGGTATGA

Antitoxin

Protein

• Length: 66 a.a.
• Molecular weight: 7658.53 Da
• Isoelectric Point: 7.2046

>AT90124 WP_001324224.1 NZ_CP025329:14581-14778 [Escherichia coli]
MDRNGSQLIRDFMRQTVERQHNTWFRDQVEAGRQQLERGDVLPHDMVESSAAAWRDEMSRKVAGK

Nucleotide

• Length: 198 bp

>AT90124 NZ_CP025329:14581-14778 [Escherichia coli]
ATGGACCGTAATGGCTCTCAGTTAATCCGGGATTTTATGCGCCAGACCGTGGAACGGCAGCATAATACCTGGTTCCGTGA
CCAGGTTGAGGCAGGACGTCAGCAACTCGAGCGCGGCGATGTGCTTCCCCATGACATGGTCGAATCTTCCGCTGCTGCAT
GGCGGGATGAAATGAGCAGGAAAGTCGCCGGTAAATGA

Structures

Toxin

• AlphaFold DB: A0A075MDK3