Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2241669..2242500 Replicon chromosome
Accession NZ_CP025328
Organism Escherichia coli strain ExPEC XM

Toxin (Protein)


Gene name yeeV Uniprot ID S1P968
Locus tag CXG97_RS11920 Protein ID WP_000854814.1
Coordinates 2242126..2242500 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID S1PWQ3
Locus tag CXG97_RS11915 Protein ID WP_001285586.1
Coordinates 2241669..2242037 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CXG97_RS11875 2236886..2237956 + 1071 WP_000102631.1 patatin-like phospholipase family protein -
CXG97_RS11880 2238092..2238769 + 678 WP_001362823.1 hypothetical protein -
CXG97_RS11885 2238785..2239195 + 411 WP_000846704.1 hypothetical protein -
CXG97_RS11895 2239416..2240237 + 822 WP_001234569.1 DUF945 domain-containing protein -
CXG97_RS11900 2240328..2240813 + 486 WP_000213703.1 antirestriction protein -
CXG97_RS11905 2240829..2241305 + 477 WP_001351157.1 RadC family protein -
CXG97_RS11910 2241374..2241595 + 222 WP_000692323.1 DUF987 domain-containing protein -
CXG97_RS11915 2241669..2242037 + 369 WP_001285586.1 type IV toxin-antitoxin system toxin CbtA Antitoxin
CXG97_RS11920 2242126..2242500 + 375 WP_000854814.1 type IV toxin-antitoxin system toxin CbtA Toxin
CXG97_RS11925 2242497..2242691 + 195 WP_000988601.1 hypothetical protein -
CXG97_RS28970 2242704..2242817 + 114 WP_001161660.1 DUF957 domain-containing protein -
CXG97_RS11930 2243106..2243252 - 147 Protein_2185 transposase domain-containing protein -
CXG97_RS11935 2243306..2243488 + 183 WP_001016348.1 hypothetical protein -
CXG97_RS11940 2243589..2243918 - 330 WP_000450409.1 DUF496 family protein -
CXG97_RS11945 2244090..2245148 - 1059 WP_001200890.1 FUSC family protein -
CXG97_RS11950 2245346..2245819 - 474 WP_001105376.1 DNA gyrase inhibitor SbmC -
CXG97_RS11955 2245938..2247104 - 1167 WP_001297905.1 serine-type D-Ala-D-Ala carboxypeptidase DacD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13898.94 Da        Isoelectric Point: 7.8522

>T90117 WP_000854814.1 NZ_CP025328:2242126-2242500 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T90117 NZ_CP025328:2242126-2242500 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTACGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13563.41 Da        Isoelectric Point: 5.0468

>AT90117 WP_001285586.1 NZ_CP025328:2241669-2242037 [Escherichia coli]
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELSPRYQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT90117 NZ_CP025328:2241669-2242037 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTACCCTGCACCGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGTTGCTGATGAAACAACTGGAGCTCATGCTCACCAGTGGT
GAACTCAGCCCCCGCTATCAGCATACCGTCACGCTGTATGCGAAAGGACTGACCTGCGAAGCCGATACCCTGGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FY50

Antitoxin

Source ID Structure
AlphaFold DB S1PWQ3

References