Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 3188302..3188780 Replicon chromosome
Accession NZ_CP025318
Organism Escherichia coli strain FORC_042

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A891SFN9
Locus tag FORC42_RS17180 Protein ID WP_001303876.1
Coordinates 3188493..3188780 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XD67
Locus tag FORC42_RS17175 Protein ID WP_000536233.1
Coordinates 3188302..3188493 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FORC42_RS17140 3183682..3184452 - 771 WP_024215598.1 DUF1627 domain-containing protein -
FORC42_RS17145 3184474..3185220 - 747 WP_000788751.1 ATP-binding protein -
FORC42_RS17150 3185227..3186342 - 1116 WP_001205820.1 hypothetical protein -
FORC42_RS17155 3186421..3186876 + 456 WP_000273724.1 hypothetical protein -
FORC42_RS17160 3187083..3187508 - 426 WP_000693855.1 Rha family transcriptional regulator -
FORC42_RS17165 3187492..3187764 - 273 WP_000887453.1 helix-turn-helix domain-containing protein -
FORC42_RS17170 3187873..3188274 + 402 WP_000986592.1 helix-turn-helix domain-containing protein -
FORC42_RS17175 3188302..3188493 + 192 WP_000536233.1 hypothetical protein Antitoxin
FORC42_RS17180 3188493..3188780 + 288 WP_001303876.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FORC42_RS17185 3189057..3189212 + 156 WP_000379575.1 DUF1391 family protein -
FORC42_RS17195 3189354..3189743 + 390 WP_000394511.1 hypothetical protein -
FORC42_RS17200 3189930..3190115 - 186 WP_024215602.1 hypothetical protein -
FORC42_RS17210 3190689..3190877 + 189 WP_000413705.1 cell division inhibition protein DicB -
FORC42_RS17215 3190874..3191065 + 192 WP_001098307.1 DUF1482 family protein -
FORC42_RS17220 3191159..3193594 + 2436 WP_104951234.1 exonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10978.84 Da        Isoelectric Point: 10.1360

>T90090 WP_001303876.1 NZ_CP025318:3188493-3188780 [Escherichia coli]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI

Download         Length: 288 bp

>T90090 NZ_CP025318:3188493-3188780 [Escherichia coli]
ATGTTACCCATTTTATGGCTACCGTCTGCTCGCGATGATTTGCGCCAGATCATAACTTACATCGCCAAGGAGAACCCACC
GGCAGCACGTAGACTAAAAATACGCATTGAAACATCGGTATTACCTCTATCTGAGCATCCGTACTTATATCCACCAAGCG
AACGGGTTTCTGGATTGAGAGAGATCGTGACCCACCCTAACTACATAATCCTGTACAGAGTAGCAGCTTCAAGCATTGAG
ATTGTAAGCGTGACACATTCTCGGCGACAATTTCCCTTCTCTATCTGA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7025.80 Da        Isoelectric Point: 4.0270

>AT90090 WP_000536233.1 NZ_CP025318:3188302-3188493 [Escherichia coli]
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE

Download         Length: 192 bp

>AT90090 NZ_CP025318:3188302-3188493 [Escherichia coli]
ATGGGTACAGCCCTTTCTCCGATAGTTTCAGAATTCGAAACTACCGAACAAGAAAACAGTTACAACGAATGGTTGCGCAC
TAAAGTAACGTCAAGCCTTGCAGACACTCGCCCCGCAATTCCACATGACGAGGTAATGGCTGAAATGGAAAATCTTATTG
CTCAAATTGCTGTAACTAACAAGAGCGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References