Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 4098999..4099615 Replicon chromosome
Accession NZ_CP025317
Organism Escherichia albertii strain 1551-2

Toxin (Protein)


Gene name vapC Uniprot ID A0A8D9PNC1
Locus tag CXP54_RS20880 Protein ID WP_044713737.1
Coordinates 4099241..4099615 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag CXP54_RS20875 Protein ID WP_103054107.1
Coordinates 4098999..4099241 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CXP54_RS20830 4094549..4095148 + 600 WP_002460585.1 glucose-1-phosphatase -
CXP54_RS20835 4095142..4096014 + 873 WP_000916663.1 virulence factor BrkB family protein -
CXP54_RS20840 4096011..4096448 + 438 WP_000560977.1 D-tyrosyl-tRNA(Tyr) deacylase -
CXP54_RS20845 4096493..4097434 + 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
CXP54_RS20850 4097452..4097517 + 66 Protein_3841 transcriptional regulator -
CXP54_RS20855 4097602..4097814 + 213 WP_103054105.1 hypothetical protein -
CXP54_RS20860 4097876..4098154 + 279 WP_103054106.1 hypothetical protein -
CXP54_RS20870 4098553..4098771 + 219 WP_001314326.1 ribbon-helix-helix domain-containing protein -
CXP54_RS20875 4098999..4099241 + 243 WP_103054107.1 ribbon-helix-helix domain-containing protein Antitoxin
CXP54_RS20880 4099241..4099615 + 375 WP_044713737.1 type II toxin-antitoxin system VapC family toxin Toxin
CXP54_RS20885 4099652..4100581 - 930 WP_000027704.1 formate dehydrogenase accessory protein FdhE -
CXP54_RS20890 4100578..4101213 - 636 WP_000829019.1 formate dehydrogenase cytochrome b556 subunit -
CXP54_RS20895 4101210..4102112 - 903 WP_059225175.1 formate dehydrogenase O subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-115)

Antitoxin

Ribbon-helix-helix protein, CopG

(15-48)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13940.21 Da        Isoelectric Point: 9.4803

>T90073 WP_044713737.1 NZ_CP025317:4099241-4099615 [Escherichia albertii]
MAKRTALFDTNILIDLFSGRIEAKQALEAWPLQNAISLVTWMEVLAGAKKYNQEHRIRIAMSAFNVIGISQDIAERSVAL
RQEYRMKLPDAIILATAQIYGFELVTRNTRDFAGIAGVITPYQP

Download         Length: 375 bp

>T90073 NZ_CP025317:4099241-4099615 [Escherichia albertii]
ATGGCAAAAAGAACTGCGCTTTTTGATACCAATATCCTTATTGATTTGTTCAGCGGACGAATTGAGGCAAAACAGGCACT
GGAGGCATGGCCCCTACAGAATGCGATTAGTCTGGTCACATGGATGGAGGTGCTGGCTGGCGCTAAAAAATACAATCAAG
AACATCGCATACGGATTGCAATGAGTGCGTTTAACGTTATTGGGATTTCGCAGGATATAGCGGAACGAAGCGTTGCTTTG
AGGCAAGAGTATAGAATGAAACTTCCAGATGCCATTATTCTGGCAACAGCACAGATTTATGGCTTTGAATTGGTAACGCG
AAATACGAGAGATTTTGCGGGAATAGCAGGTGTAATCACACCCTATCAACCGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9272.61 Da        Isoelectric Point: 4.4819

>AT90073 WP_103054107.1 NZ_CP025317:4098999-4099241 [Escherichia albertii]
MSAMAGMDMGRILLDLSDEVIKRLDDLKVQRNLPRAELLREAVAQYLENQSKTTIFSALGIWQGCEEDGVEYQRKLREEW

Download         Length: 243 bp

>AT90073 NZ_CP025317:4098999-4099241 [Escherichia albertii]
ATGAGCGCTATGGCAGGTATGGATATGGGCAGAATTTTACTCGATTTATCCGATGAGGTGATTAAGCGACTTGATGATCT
CAAAGTGCAGCGCAATCTTCCTCGCGCAGAGCTATTACGAGAAGCGGTAGCTCAATATCTGGAAAATCAATCGAAAACGA
CAATATTCAGTGCTCTTGGTATCTGGCAAGGGTGTGAGGAAGATGGTGTCGAATATCAGCGTAAGCTGCGTGAGGAATGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References