Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 448632..449250 Replicon chromosome
Accession NZ_CP025317
Organism Escherichia albertii strain 1551-2

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag CXP54_RS02180 Protein ID WP_001280991.1
Coordinates 448632..448850 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID B1EKM5
Locus tag CXP54_RS02185 Protein ID WP_000344798.1
Coordinates 448876..449250 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CXP54_RS02145 443921..444493 + 573 WP_000779847.1 YbaY family lipoprotein -
CXP54_RS02150 444523..444834 - 312 WP_000409915.1 MGMT family protein -
CXP54_RS02160 445215..445568 + 354 WP_000878151.1 DUF1428 family protein -
CXP54_RS02165 445606..447156 - 1551 WP_103053318.1 EAL domain-containing protein -
CXP54_RS02170 447320..447790 - 471 WP_059224581.1 YlaC family protein -
CXP54_RS02175 447898..448455 - 558 WP_000093561.1 maltose O-acetyltransferase -
CXP54_RS02180 448632..448850 - 219 WP_001280991.1 hemolysin expression modulator Hha Toxin
CXP54_RS02185 448876..449250 - 375 WP_000344798.1 Hha toxicity modulator TomB Antitoxin
CXP54_RS02190 449805..452954 - 3150 WP_001132500.1 multidrug efflux RND transporter permease subunit -
CXP54_RS02195 452977..454170 - 1194 WP_010334435.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T90051 WP_001280991.1 NZ_CP025317:c448850-448632 [Escherichia albertii]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T90051 NZ_CP025317:c448850-448632 [Escherichia albertii]
ATGTCCGATAAACCTTTAACAAAAACCGATTATTTGATGCGTCTGCGTCGTTGCCAGACAATTGACACGCTGGAACGTGT
TATCGAGAAAAATAAATATGAATTATCAGATAATGAATTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTTGCAGAGC
TGACTATGAATAAGCTATATGACAAGATCCCTTCCTCAGTGTGGAAATTCATTCGGTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14499.35 Da        Isoelectric Point: 4.8989

>AT90051 WP_000344798.1 NZ_CP025317:c449250-448876 [Escherichia albertii]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKANPASLSC

Download         Length: 375 bp

>AT90051 NZ_CP025317:c449250-448876 [Escherichia albertii]
ATGGATGAATACTCACCAAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGTAACCATGGCTGGGTAAATGACCCAACCTCGGCAATCAATCTACAGCTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAACAGATTGATGAATATCTG
GACGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAACCGATT
GTTCCGTTGCTTTGTTAACGCCACCAAAGCGAATCCTGCAAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A2T3RX90

References