Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 2295215..2295834 Replicon chromosome
Accession NZ_CP025309
Organism Pseudomonas chlororaphis strain Lzh-T5

Toxin (Protein)


Gene name hicA Uniprot ID A0A3G7DMG3
Locus tag CXP47_RS10470 Protein ID WP_009048155.1
Coordinates 2295652..2295834 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A285IZU0
Locus tag CXP47_RS10465 Protein ID WP_007923747.1
Coordinates 2295215..2295616 (-) Length 134 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CXP47_RS10450 2291095..2292984 + 1890 WP_101282089.1 PAS domain S-box protein -
CXP47_RS10455 2292981..2293616 + 636 WP_101282090.1 response regulator transcription factor -
CXP47_RS10460 2293710..2294474 + 765 WP_101282091.1 hypothetical protein -
CXP47_RS10465 2295215..2295616 - 402 WP_007923747.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
CXP47_RS10470 2295652..2295834 - 183 WP_009048155.1 type II toxin-antitoxin system HicA family toxin Toxin
CXP47_RS10475 2296212..2296493 - 282 WP_063429473.1 hypothetical protein -
CXP47_RS30810 2297051..2297875 - 825 WP_157832214.1 hypothetical protein -
CXP47_RS10480 2297877..2299577 - 1701 WP_101282092.1 ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2295215..2301196 5981


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6799.98 Da        Isoelectric Point: 10.9678

>T90045 WP_009048155.1 NZ_CP025309:c2295834-2295652 [Pseudomonas chlororaphis]
VQSRQLIKELEAAGWVLERVTGSHHLFKHPYRPETVPVPHPKKDLPRGTVRAIQKLAGLI

Download         Length: 183 bp

>T90045 NZ_CP025309:c2295834-2295652 [Pseudomonas chlororaphis]
GTGCAAAGCAGACAGTTGATCAAGGAGCTTGAAGCCGCAGGCTGGGTGCTGGAGCGCGTTACCGGCAGCCATCATCTGTT
CAAGCATCCCTATCGGCCCGAGACCGTTCCGGTGCCTCACCCGAAGAAGGATCTGCCACGGGGGACGGTCAGGGCCATCC
AGAAACTGGCCGGGCTGATATAG

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14579.54 Da        Isoelectric Point: 4.6017

>AT90045 WP_007923747.1 NZ_CP025309:c2295616-2295215 [Pseudomonas chlororaphis]
VQYPICIEWGDEHTATGIQIPDIPGAVTAGDTFEAAYSAAIEIAHVMLEELAREGQAIPLPSPTGTHRANPDFEGMGWGM
LDIDITPYLGKTEKVNVTLPGYVIQRIDRFVREHNIKSRSSFLADAAMEKLGR

Download         Length: 402 bp

>AT90045 NZ_CP025309:c2295616-2295215 [Pseudomonas chlororaphis]
GTGCAATATCCCATCTGCATCGAGTGGGGTGACGAGCACACTGCTACCGGCATCCAGATTCCTGATATTCCTGGGGCGGT
AACCGCCGGCGACACCTTCGAGGCCGCGTACAGCGCCGCCATCGAGATCGCCCACGTCATGCTCGAAGAACTGGCCCGCG
AGGGGCAAGCCATTCCCCTGCCCTCGCCCACCGGCACGCACCGCGCCAACCCCGACTTCGAGGGGATGGGCTGGGGCATG
CTGGATATCGACATCACGCCTTACCTGGGCAAAACCGAAAAGGTCAATGTGACCCTGCCGGGCTACGTGATTCAACGAAT
CGACCGCTTTGTACGGGAGCACAACATCAAGAGCCGGTCGTCTTTCCTGGCGGATGCGGCGATGGAAAAGCTGGGGCGTT
AA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G7DMG3

Antitoxin

Source ID Structure
AlphaFold DB A0A285IZU0

References