90037

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) BrnTA/BrnT_toxin-BrnA
Location 534807..535344 Replicon chromosome
Accession NZ_CP025307
Organism Burkholderia pseudomallei strain D286

Toxin (Protein)


Gene name brnT Uniprot ID Q2T6G2
Locus tag D286_RS21590 Protein ID WP_004549731.1
Coordinates 534807..535076 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name brnA Uniprot ID Q63NA3
Locus tag D286_RS21595 Protein ID WP_004525420.1
Coordinates 535060..535344 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D286_RS21555 530551..531591 - 1041 WP_197970191.1 ImmA/IrrE family metallo-endopeptidase -
D286_RS21560 531807..532091 - 285 WP_009961460.1 type II toxin-antitoxin system HigB family toxin -
D286_RS33475 532995..533237 - 243 WP_009961458.1 hypothetical protein -
D286_RS33480 533285..533443 - 159 WP_004549802.1 hypothetical protein -
D286_RS21570 533440..533682 - 243 WP_004545584.1 hypothetical protein -
D286_RS21580 533820..533951 - 132 WP_009923452.1 bacteriophage protein Gp48 -
D286_RS21585 533961..534236 - 276 WP_025988352.1 hypothetical protein -
D286_RS21590 534807..535076 + 270 WP_004549731.1 BrnT family toxin Toxin
D286_RS21595 535060..535344 + 285 WP_004525420.1 BrnA antitoxin family protein Antitoxin
D286_RS21600 535991..536374 + 384 Protein_440 DDE-type integrase/transposase/recombinase -
D286_RS21605 536337..536765 + 429 Protein_441 IS110 family transposase -
D286_RS21610 536992..537108 - 117 Protein_442 IS3 family transposase -
D286_RS21615 537355..538815 + 1461 WP_011326543.1 metallophosphoesterase -
D286_RS21620 538974..540236 + 1263 WP_004537187.1 c-type cytochrome -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 516832..536374 19542


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(5-81)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(27-88)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10157.46 Da        Isoelectric Point: 5.6831

>T90037 WP_004549731.1 NZ_CP025307:534807-535076 [Burkholderia pseudomallei]
MDITFDPTKNETNIAKHGVSLALAAQLDWSDVLSYVDDRRDYSEVREVGFGVIGDRLYCVVFTQRGDSMHIISMRKANKR
EVKSYVEQA

Download         Length: 270 bp

>T90037 NZ_CP025307:534807-535076 [Burkholderia pseudomallei]
ATGGACATCACCTTTGACCCGACCAAGAACGAAACGAACATTGCCAAGCATGGAGTGTCGTTGGCGCTTGCAGCGCAACT
CGACTGGTCGGACGTGTTGTCCTACGTGGACGACCGACGCGACTACAGTGAAGTGCGCGAAGTCGGGTTCGGTGTGATCG
GCGATCGCCTCTATTGCGTGGTGTTCACGCAGCGCGGCGACTCGATGCACATCATCAGCATGCGTAAGGCGAACAAGCGG
GAGGTCAAGAGCTATGTCGAGCAAGCGTAA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10697.10 Da        Isoelectric Point: 5.8930

>AT90037 WP_004525420.1 NZ_CP025307:535060-535344 [Burkholderia pseudomallei]
MSSKRKIVMPTDEEDAAINRGIAADPDTFEVPAEDFAKMTRRGKRGRPPLEAPKVQLTVRYDVDIVDAFKATGEGWQTRM
NDALREWLREHQPA

Download         Length: 285 bp

>AT90037 NZ_CP025307:535060-535344 [Burkholderia pseudomallei]
ATGTCGAGCAAGCGTAAGATCGTCATGCCGACGGACGAGGAAGACGCGGCAATCAACCGCGGCATCGCGGCCGATCCCGA
CACGTTCGAAGTGCCGGCGGAAGACTTCGCGAAGATGACGCGGCGAGGCAAGCGTGGTCGTCCGCCGCTCGAAGCGCCCA
AGGTGCAATTGACGGTGCGCTATGACGTCGACATTGTCGACGCCTTCAAGGCAACGGGCGAAGGTTGGCAGACGCGCATG
AATGATGCGTTACGCGAGTGGCTGAGGGAACATCAGCCTGCGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q2T6G2

Antitoxin

Source ID Structure
AlphaFold DB A0A0F6L9S8

References