Detailed information of TA system TA090024

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-StbC
• Location: 2346973..2347647
• Replicon: chromosome
• Accession: NZ_CP025272
• Organism: Xanthomonas vasicola pv. vasculorum strain Xv1601

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: A0A837APC7
• Locus tag: CXP37_RS10965
• Protein ID: WP_010373126.1
• Coordinates: 2347228..2347647 (+)
• Length: 140 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A837APP1
• Locus tag: CXP37_RS10960
• Protein ID: WP_010373123.1
• Coordinates: 2346973..2347227 (+)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CXP37_RS10925	2342153..2342368	-	216	WP_010370235.1	hypothetical protein	-
CXP37_RS10930	2342926..2343288	+	363	WP_087910995.1	CopG family transcriptional regulator	-
CXP37_RS10935	2343390..2344385	+	996	WP_087910994.1	DUF4935 domain-containing protein	-
CXP37_RS10940	2344841..2345287	+	447	WP_017115703.1	hypothetical protein	-
CXP37_RS10945	2345352..2345543	+	192	WP_010373115.1	hypothetical protein	-
CXP37_RS10950	2345799..2346773	-	975	WP_199285780.1	DUF2326 domain-containing protein	-
CXP37_RS10960	2346973..2347227	+	255	WP_010373123.1	plasmid stabilization protein	Antitoxin
CXP37_RS10965	2347228..2347647	+	420	WP_010373126.1	type II toxin-antitoxin system VapC family toxin	Toxin
CXP37_RS10970	2347817..2348602	+	786	WP_087910997.1	P-type conjugative transfer protein TrbJ	-
CXP37_RS10975	2348618..2348893	+	276	WP_017115702.1	entry exclusion lipoprotein TrbK	-
CXP37_RS10980	2348890..2350524	+	1635	WP_010373135.1	P-type conjugative transfer protein TrbL	-
CXP37_RS10985	2350591..2350818	+	228	WP_010373138.1	type I toxin-antitoxin system ptaRNA1 family toxin	-
CXP37_RS10990	2351058..2351417	-	360	WP_010373141.1	hypothetical protein	-
CXP37_RS10995	2351592..2352173	+	582	WP_017122811.1	recombinase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	2277727..2364538	86811

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-128)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 140 a.a.
• Molecular weight: 15049.13 Da
• Isoelectric Point: 4.5762

>T90024 WP_010373126.1 NZ_CP025272:2347228-2347647 [Xanthomonas vasicola pv. vasculorum]
MIVLDTNVVSEAMKPEPDAAVRAWLNDQAAETLYLSSVTLAELLFGIRALPAGKRKNMLDRALTELLELFKDRVLPFDTD
AARHYADLAVTAKNGGRGFPTPDGYIAAVAASRGFIVASRDTSPYEAAGVNVINPWEDV

Nucleotide

• Length: 420 bp

>T90024 NZ_CP025272:2347228-2347647 [Xanthomonas vasicola pv. vasculorum]
ATGATCGTCCTGGATACCAACGTCGTTTCAGAGGCGATGAAGCCGGAGCCGGACGCGGCCGTGAGGGCCTGGCTGAACGA
CCAAGCGGCGGAAACCTTGTACCTGTCCAGCGTCACGCTGGCCGAGTTGCTGTTTGGCATCCGGGCGCTGCCGGCGGGCA
AGCGCAAGAACATGCTCGACCGCGCTCTGACCGAGCTGCTGGAACTGTTCAAGGATCGGGTCTTGCCGTTCGATACGGAT
GCAGCGCGCCACTATGCCGACCTGGCCGTGACGGCCAAGAACGGCGGGCGCGGCTTCCCGACGCCAGACGGCTACATCGC
GGCCGTTGCAGCCTCGCGGGGCTTCATCGTGGCATCGCGCGACACATCGCCCTATGAAGCGGCTGGCGTGAATGTCATCA
ACCCTTGGGAGGATGTATAG

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9274.71 Da
• Isoelectric Point: 10.5807

>AT90024 WP_010373123.1 NZ_CP025272:2346973-2347227 [Xanthomonas vasicola pv. vasculorum]
MAILTVRNVPDDVHRALRVRAAQHGRSTEAEVREILAAVVKPEKRVRVGEALAAIGRKIGLTNEDFAVFESVRDKTPAKP
LSFE

Nucleotide

• Length: 255 bp

>AT90024 NZ_CP025272:2346973-2347227 [Xanthomonas vasicola pv. vasculorum]
ATGGCAATTCTGACTGTAAGGAATGTGCCGGATGACGTGCATCGCGCTTTGCGCGTGCGGGCGGCCCAACATGGCCGCAG
TACGGAAGCGGAGGTGCGCGAGATTCTGGCGGCCGTGGTCAAGCCGGAGAAGCGCGTGCGTGTGGGTGAAGCCCTAGCCG
CCATCGGCCGCAAGATCGGGCTGACCAATGAGGATTTCGCCGTGTTCGAGAGCGTGCGCGACAAGACGCCGGCCAAACCG
TTGAGCTTCGAGTGA

Structures

Toxin

• AlphaFold DB: A0A837APC7

Antitoxin

• AlphaFold DB: A0A837APP1