Detailed information of TA system TA089978

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/-
• Location: 1628738..1629391
• Replicon: chromosome
• Accession: NZ_CP025266
• Organism: Acinetobacter baumannii isolate SMC_Paed_Ab_BL01

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: CV094_RS07735
• Protein ID: WP_000607077.1
• Coordinates: 1628738..1629127 (-)
• Length: 130 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: V5V966
• Locus tag: CV094_RS07740
• Protein ID: WP_001288210.1
• Coordinates: 1629134..1629391 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CV094_RS07720	1623856..1626051	-	2196	WP_001158906.1	TRAP transporter large permease subunit	-
CV094_RS07725	1626239..1626805	-	567	WP_000651538.1	rhombosortase	-
CV094_RS07730	1626883..1627968	-	1086	WP_000049106.1	hypothetical protein	-
CV094_RS07735	1628738..1629127	-	390	WP_000607077.1	membrane protein	Toxin
CV094_RS07740	1629134..1629391	-	258	WP_001288210.1	succinate dehydrogenase assembly factor 2	Antitoxin
CV094_RS07745	1629579..1630751	+	1173	WP_001190542.1	acyl-CoA dehydrogenase family protein	-
CV094_RS07750	1630800..1632290	-	1491	WP_000415125.1	NAD(P)/FAD-dependent oxidoreductase	-
CV094_RS07755	1632472..1632849	-	378	WP_001216380.1	50S ribosomal protein L17	-
CV094_RS07760	1632868..1633875	-	1008	WP_000198631.1	DNA-directed RNA polymerase subunit alpha	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Flavinator of succinate dehydrogenase (10-82)

Sequences

Toxin

Protein

• Length: 130 a.a.
• Molecular weight: 15552.88 Da
• Isoelectric Point: 10.4313

>T89978 WP_000607077.1 NZ_CP025266:c1629127-1628738 [Acinetobacter baumannii]
MINHLNFKLKYSRFSIIFQFFIGLSLAVLFYQLMPLLWWLVVISLLFISFIFFLKRPQLAQIAYLDKKLWSLAYKSQNTV
SRVKILKIIDCQIFIVIYFEGHKTLTSIIWFDQMSLAEWKKLKTLEKLY

Nucleotide

• Length: 390 bp

>T89978 NZ_CP025266:c1629127-1628738 [Acinetobacter baumannii]
TTGATCAACCATTTGAATTTTAAGCTGAAATATAGTCGTTTTTCGATTATATTTCAGTTTTTTATTGGCTTAAGCTTAGC
AGTTCTATTTTATCAATTAATGCCGTTACTATGGTGGTTAGTTGTAATCAGCTTACTATTTATCAGCTTTATTTTCTTTT
TAAAGCGTCCGCAGCTTGCACAAATTGCTTATTTAGATAAAAAACTATGGTCGCTTGCTTATAAGTCACAGAACACCGTT
TCTCGCGTCAAAATTTTAAAAATAATTGATTGTCAGATTTTCATAGTGATCTATTTTGAAGGTCATAAAACACTAACTTC
TATCATTTGGTTTGATCAAATGTCATTAGCAGAGTGGAAAAAGCTTAAAACTTTAGAAAAACTCTATTAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 10318.77 Da
• Isoelectric Point: 4.6150

>AT89978 WP_001288210.1 NZ_CP025266:c1629391-1629134 [Acinetobacter baumannii]
MSEEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLK
HYVHG

Nucleotide

• Length: 258 bp

>AT89978 NZ_CP025266:c1629391-1629134 [Acinetobacter baumannii]
ATGTCTGAAGAAATGACCTTGGAAGAACGTAAAGTAATCTATCGCGCACGTCGTGGTTTAAAGGAAATTGATGTCTATTT
TGACCCTTATGTGAAAAATTATTATTTAAAGGCAGACCCGGCAGAAAAAGCGTTGTTTGCTGAGTTGGTAGAACAGGAAG
ACCCTGATTTACTAGATTGGTTTATGGAAGTATCAGAACCACCACGTACCGAATTACGTGACTTTATCTATAAATTAAAA
CACTATGTTCATGGTTAA

Structures

Antitoxin

• AlphaFold DB: A0A7U4BQM7