Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1064863..1065514 Replicon chromosome
Accession NZ_CP025266
Organism Acinetobacter baumannii isolate SMC_Paed_Ab_BL01

Toxin (Protein)


Gene name hicA Uniprot ID S3TWT7
Locus tag CV094_RS05050 Protein ID WP_000838146.1
Coordinates 1065332..1065514 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A0J1AAF8
Locus tag CV094_RS05045 Protein ID WP_000966689.1
Coordinates 1064863..1065267 (-) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CV094_RS05030 1059896..1060237 - 342 WP_001281459.1 phage tail protein -
CV094_RS05035 1060355..1064320 - 3966 WP_000191304.1 tape measure protein -
CV094_RS05040 1064381..1064782 - 402 WP_000720591.1 hypothetical protein -
CV094_RS05045 1064863..1065267 - 405 WP_000966689.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
CV094_RS05050 1065332..1065514 - 183 WP_000838146.1 type II toxin-antitoxin system HicA family toxin Toxin
CV094_RS05055 1065845..1066378 - 534 WP_001185622.1 hypothetical protein -
CV094_RS05060 1066423..1067352 - 930 WP_000094300.1 hypothetical protein -
CV094_RS05065 1067460..1067672 - 213 WP_000121166.1 hypothetical protein -
CV094_RS05070 1067674..1068072 - 399 WP_001132270.1 hypothetical protein -
CV094_RS05075 1068074..1068442 - 369 WP_000539752.1 hypothetical protein -
CV094_RS05080 1068414..1068818 - 405 WP_000248324.1 hypothetical protein -
CV094_RS05085 1068827..1069195 - 369 WP_000524231.1 hypothetical protein -
CV094_RS05090 1069197..1069586 - 390 WP_000008492.1 hypothetical protein -
CV094_RS05095 1069591..1070256 - 666 WP_000767881.1 stress-responsive nuclear envelope protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1041292..1095906 54614


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-126)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6695.84 Da        Isoelectric Point: 10.5523

>T89977 WP_000838146.1 NZ_CP025266:c1065514-1065332 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Download         Length: 183 bp

>T89977 NZ_CP025266:c1065514-1065332 [Acinetobacter baumannii]
GTGAAAAGTCTGGATTTAATCAAAATGATTGAAGCAGACGGTTGGTATGAGGTTAGGGTTTCAGGAAGTCATCATCACTT
CAAACACCCAACCAAAAAGGGATTAGTAACAATCCCTCATCCTAAAAAGGATTTACCAAACGGAACTGTTAAAAGCATTT
TGAAGCAAGCGGGTCTAAATTGA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14769.78 Da        Isoelectric Point: 4.5000

>AT89977 WP_000966689.1 NZ_CP025266:c1065267-1064863 [Acinetobacter baumannii]
MLYPIAIERGTDTEAFGVSVPDIPGCFSAGDTLYEAIENVKEAISGHLEILAEDGEEIPLASDVSKFIDQEDYRGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDDNVGKDKRFKTRSAFLAAGAEKLLHA

Download         Length: 405 bp

>AT89977 NZ_CP025266:c1065267-1064863 [Acinetobacter baumannii]
ATGTTATATCCAATTGCTATTGAAAGAGGTACAGACACCGAAGCCTTTGGTGTCTCCGTTCCAGATATTCCAGGGTGTTT
CAGCGCAGGCGATACATTATATGAAGCTATCGAGAATGTTAAAGAGGCTATTTCTGGCCACTTGGAAATCCTAGCAGAAG
ATGGAGAGGAGATTCCTTTAGCATCTGATGTCAGTAAGTTTATTGACCAAGAAGATTATAGAGGTATGATCTGGGCAGTT
ACTGAAGTTGATGTTAGCCGTTACTTAGGTAAACCAGAAAAAATCAATGTTACTTTACCAAGCCGATTAATTCGGAAGAT
TGATGATAATGTTGGTAAAGATAAAAGATTTAAAACTCGCTCTGCTTTTTTGGCCGCTGGTGCTGAAAAGCTACTACATG
CTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S3TWT7

Antitoxin

Source ID Structure
AlphaFold DB A0A0J1AAF8

References