Detailed information of TA system TA089928

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-StbC
• Location: 2801971..2802512
• Replicon: chromosome
• Accession: NZ_CP025249
• Organism: Actinomyces sp. 432

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: CWT12_RS11670
• Protein ID: WP_202616208.1
• Coordinates: 2801971..2802276 (-)
• Length: 102 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: CWT12_RS11675
• Protein ID: WP_161924939.1
• Coordinates: 2802273..2802512 (-)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CWT12_RS11650	2797286..2797885	+	600	WP_161924935.1	Abi family protein	-
CWT12_RS11655	2798457..2798765	-	309	WP_161924936.1	hypothetical protein	-
CWT12_RS11660	2799144..2799989	-	846	WP_161924937.1	alpha/beta hydrolase	-
CWT12_RS11665	2801134..2801325	-	192	WP_161924938.1	hypothetical protein	-
CWT12_RS11670	2801971..2802276	-	306	WP_202616208.1	PIN domain-containing protein	Toxin
CWT12_RS11675	2802273..2802512	-	240	WP_161924939.1	Arc family DNA-binding protein	Antitoxin
CWT12_RS11680	2803151..2805799	+	2649	WP_161924940.1	DUF1998 domain-containing protein	-
CWT12_RS11685	2805970..2806728	-	759	WP_161924941.1	A24 family peptidase	-
CWT12_RS11690	2806991..2807410	-	420	WP_161924942.1	flp pilus-assembly TadE/G-like family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2792517..2802512	9995

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-93)

Antitoxin

• Arc-like DNA binding domain (9-39)

Sequences

Toxin

Protein

• Length: 102 a.a.
• Molecular weight: 11330.97 Da
• Isoelectric Point: 5.1484

>T89928 WP_202616208.1 NZ_CP025249:c2802276-2801971 [Actinomyces sp. 432]
VIILDTNVISEPLRSAPEPAVVEWLDRQPQESLFVTALTLAELRRGVLALSEGRRRDTLQYRLEETLLPFFSDRVLPFDD
AAASAWAQLQARAAAKGRPCR

Nucleotide

• Length: 306 bp

>T89928 NZ_CP025249:c2802276-2801971 [Actinomyces sp. 432]
GTGATCATTCTCGATACGAATGTCATCTCCGAGCCGTTGCGTAGTGCACCGGAGCCGGCGGTTGTTGAATGGCTCGATCG
GCAGCCTCAGGAGTCGCTGTTCGTGACCGCCCTGACGCTTGCCGAGTTGCGGCGGGGTGTCTTGGCCCTGTCGGAAGGGC
GACGACGAGACACGCTCCAGTACCGATTGGAGGAGACGCTGCTGCCGTTCTTCAGTGACAGGGTCCTTCCGTTCGATGAT
GCTGCCGCAAGCGCGTGGGCGCAGTTGCAGGCGCGGGCAGCCGCCAAAGGGCGCCCCTGCCGGTGA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 8546.74 Da
• Isoelectric Point: 5.6558

>AT89928 WP_161924939.1 NZ_CP025249:c2802512-2802273 [Actinomyces sp. 432]
MADVLVRNLPDGTHRALKALAKSHGRSMEAEIRQILGRAVAANDRPGLGSLLTSIREEVGPVELDMDRDDAPYVPVNLS

Nucleotide

• Length: 240 bp

>AT89928 NZ_CP025249:c2802512-2802273 [Actinomyces sp. 432]
ATGGCAGATGTTCTGGTTCGGAACCTGCCCGATGGGACCCACCGGGCATTGAAGGCGCTGGCGAAGTCGCATGGTCGCAG
CATGGAGGCCGAGATACGGCAGATCCTGGGACGGGCTGTTGCCGCGAATGACCGGCCCGGCCTTGGTTCGCTGCTGACTT
CGATACGCGAAGAGGTCGGGCCTGTGGAACTCGACATGGATCGTGACGACGCTCCCTATGTCCCGGTGAACCTGTCGTGA