Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-PHD
Location 1812706..1813355 Replicon chromosome
Accession NZ_CP025249
Organism Actinomyces sp. 432

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag CWT12_RS07560 Protein ID WP_161924329.1
Coordinates 1812960..1813355 (+) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag CWT12_RS07555 Protein ID WP_202616171.1
Coordinates 1812706..1812963 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CWT12_RS07530 1808119..1808967 + 849 WP_161924324.1 MerR family transcriptional regulator -
CWT12_RS07535 1809037..1809993 + 957 WP_161924325.1 ABC transporter ATP-binding protein -
CWT12_RS07540 1809990..1811621 + 1632 WP_161924326.1 Tat pathway signal protein -
CWT12_RS07545 1811734..1812093 - 360 WP_202616170.1 hypothetical protein -
CWT12_RS07550 1812144..1812611 + 468 WP_161924327.1 MarR family winged helix-turn-helix transcriptional regulator -
CWT12_RS07555 1812706..1812963 + 258 WP_202616171.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
CWT12_RS07560 1812960..1813355 + 396 WP_161924329.1 type II toxin-antitoxin system VapC family toxin Toxin
CWT12_RS07565 1813576..1814655 - 1080 WP_161924330.1 inositol-3-phosphate synthase -
CWT12_RS07570 1815219..1816064 - 846 WP_161925360.1 amino acid ABC transporter permease -
CWT12_RS07575 1816070..1816722 - 653 Protein_1479 amino acid ABC transporter permease -
CWT12_RS07580 1816816..1817828 - 1013 Protein_1480 glutamate ABC transporter substrate-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1812144..1820592 8448


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-120)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-42)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14427.53 Da        Isoelectric Point: 5.1403

>T89927 WP_161924329.1 NZ_CP025249:1812960-1813355 [Actinomyces sp. 432]
MTICYLDTSAALKLLIEEAESDPLATWLTEQTANGLSLCSSFLLHTELYCAARRRRQLDMQSTASLLSGIELIDISREHL
LNAARDTAGLRAADAIHLAVALNVRSDLLLTYDREMQQAALQRGLTVTAPR

Download         Length: 396 bp

>T89927 NZ_CP025249:1812960-1813355 [Actinomyces sp. 432]
ATGACCATTTGCTACCTGGATACCTCCGCAGCACTCAAGCTTCTCATCGAGGAAGCCGAGTCGGATCCTTTAGCCACCTG
GCTGACCGAGCAGACCGCGAACGGCTTGTCTCTGTGCTCCTCCTTCTTGCTGCACACAGAGCTGTACTGCGCCGCTCGAC
GACGCCGACAGCTCGATATGCAGTCAACCGCATCATTACTGTCGGGGATCGAACTCATTGACATCTCGCGGGAGCATCTG
CTCAACGCGGCGCGAGACACGGCGGGGCTGCGTGCGGCAGACGCGATCCACCTCGCAGTTGCCCTGAACGTACGCTCCGA
CCTGCTCCTCACTTACGACCGGGAAATGCAACAAGCTGCGCTGCAACGAGGGCTGACGGTGACCGCCCCCAGATGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9390.62 Da        Isoelectric Point: 11.0140

>AT89927 WP_202616171.1 NZ_CP025249:1812706-1812963 [Actinomyces sp. 432]
MTTIPHRELRNDSAAILRRVEAGESFAITNNGRPVAELVPITQDRLALLRRQGATRPAVPTDFNALNRARGLSSKDVLDD
LRGEQ

Download         Length: 258 bp

>AT89927 NZ_CP025249:1812706-1812963 [Actinomyces sp. 432]
ATGACTACGATTCCACACCGCGAACTACGGAACGACAGCGCCGCAATCCTCCGCCGAGTGGAGGCCGGCGAGAGTTTCGC
GATCACCAACAACGGACGTCCCGTAGCCGAGCTTGTGCCCATCACCCAGGACCGCCTCGCTCTACTGCGTCGGCAAGGAG
CTACGCGTCCAGCGGTCCCCACAGACTTCAACGCCTTAAACCGCGCGCGAGGACTCAGCTCAAAAGATGTACTGGACGAC
CTGCGCGGCGAGCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References