Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpIK/PemK(toxin)
Location 3544451..3545019 Replicon chromosome
Accession NZ_CP025228
Organism Actinomyces qiguomingii strain actinomyces sp. 410

Toxin (Protein)


Gene name chpK Uniprot ID -
Locus tag CWT10_RS14800 Protein ID WP_103061612.1
Coordinates 3544672..3545019 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name chpI Uniprot ID -
Locus tag CWT10_RS14795 Protein ID WP_103061613.1
Coordinates 3544451..3544684 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CWT10_RS14770 3540150..3541037 - 888 WP_103061618.1 NAD(P)-dependent oxidoreductase -
CWT10_RS14775 3541150..3542568 - 1419 WP_103061617.1 hypothetical protein -
CWT10_RS14780 3542654..3543346 - 693 WP_103061616.1 FadR family transcriptional regulator -
CWT10_RS14785 3543612..3543890 + 279 WP_103061615.1 hypothetical protein -
CWT10_RS14790 3543893..3544312 + 420 WP_103061614.1 type II toxin-antitoxin system VapC family toxin -
CWT10_RS14795 3544451..3544684 + 234 WP_103061613.1 hypothetical protein Antitoxin
CWT10_RS14800 3544672..3545019 + 348 WP_103061612.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
CWT10_RS14805 3545102..3546418 - 1317 Protein_2905 DDE-type integrase/transposase/recombinase -
CWT10_RS14810 3546584..3547393 - 810 WP_103062430.1 class I SAM-dependent methyltransferase -
CWT10_RS14815 3548355..3549026 + 672 WP_103062431.1 hypothetical protein -
CWT10_RS14820 3549023..3549331 + 309 WP_128683554.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-114)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 12431.36 Da        Isoelectric Point: 10.7596

>T89920 WP_103061612.1 NZ_CP025228:3544672-3545019 [Actinomyces qiguomingii]
MAVVARGEVWWLDFGDPIGSKPGYRRPALIVSSDRFNRSRIATVIVSAITSNLRLAAAPGNVGIERGEAGLSKQCVVNVS
QTLVVDRSRLSDRIGVLPAHLLNRVDDGLRLVLDV

Download         Length: 348 bp

>T89920 NZ_CP025228:3544672-3545019 [Actinomyces qiguomingii]
ATGGCAGTGGTAGCTCGCGGAGAGGTCTGGTGGCTCGACTTCGGCGATCCCATCGGCTCGAAGCCGGGTTACCGCAGACC
CGCGTTGATCGTGTCCTCAGACAGATTCAACCGATCACGCATAGCCACTGTCATTGTTTCCGCGATAACCAGCAACCTGC
GGCTGGCAGCGGCGCCAGGCAACGTCGGGATTGAGCGCGGTGAGGCGGGCCTGTCCAAGCAGTGCGTTGTAAATGTGTCG
CAAACCCTCGTAGTCGACCGCTCCAGGTTGAGCGATCGCATCGGCGTTCTCCCCGCCCACCTTCTTAATCGCGTGGACGA
CGGACTGCGCCTGGTCCTCGACGTCTGA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8572.68 Da        Isoelectric Point: 4.6855

>AT89920 WP_103061613.1 NZ_CP025228:3544451-3544684 [Actinomyces qiguomingii]
VKTAVSIPDPVFQEAEKIARRLGWSRSQLYTKAVHDLVISYSDDPVTEALNALEDVEPAQAPLAPARRLIESGAWQW

Download         Length: 234 bp

>AT89920 NZ_CP025228:3544451-3544684 [Actinomyces qiguomingii]
GTGAAGACGGCAGTATCCATACCAGACCCGGTGTTCCAGGAGGCTGAAAAAATCGCACGCCGCCTCGGATGGAGCCGGTC
GCAGCTGTACACGAAGGCCGTCCACGACCTGGTGATCAGCTACAGCGATGACCCTGTGACTGAGGCGCTTAACGCTCTTG
AGGACGTCGAGCCCGCGCAGGCCCCGTTGGCGCCGGCGAGGAGACTCATTGAGTCGGGGGCATGGCAGTGGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References