Detailed information of TA system TA089919

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC(toxin)
• Location: 3537563..3538224
• Replicon: chromosome
• Accession: NZ_CP025228
• Organism: Actinomyces qiguomingii strain actinomyces sp. 410

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: CWT10_RS14755
• Protein ID: WP_103061621.1
• Coordinates: 3537563..3537988 (-)
• Length: 142 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: CWT10_RS14760
• Protein ID: WP_103061620.1
• Coordinates: 3537985..3538224 (-)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CWT10_RS14745	3534812..3536149	-	1338	WP_103061623.1	NADP-specific glutamate dehydrogenase	-
CWT10_RS14750	3536506..3536943	-	438	WP_103061622.1	cupin domain-containing protein	-
CWT10_RS14755	3537563..3537988	-	426	WP_103061621.1	PIN domain-containing protein	Toxin
CWT10_RS14760	3537985..3538224	-	240	WP_103061620.1	division/cell wall cluster transcriptional repressor MraZ	Antitoxin
CWT10_RS14765	3538770..3540140	-	1371	WP_103061619.1	GntP family transporter	-
CWT10_RS14770	3540150..3541037	-	888	WP_103061618.1	NAD(P)-dependent oxidoreductase	-
CWT10_RS14775	3541150..3542568	-	1419	WP_103061617.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (8-127)

Antitoxin

• SpoVT-AbrB domain (3-42)

Sequences

Toxin

Protein

• Length: 142 a.a.
• Molecular weight: 14631.59 Da
• Isoelectric Point: 6.4846

>T89919 WP_103061621.1 NZ_CP025228:c3537988-3537563 [Actinomyces qiguomingii]
VNGTTRIAVDTSVAIPLLVASHEAHRPVRDWARGRRLSLSGHALAETYAVLTRLPADARVSAEDAVALIDDRFPEVLALS
ANSAITAHRRLASLGIAGGAVYDGLVALAALENGALLATRDARTRDTYEAVGVAVEVVAAG

Nucleotide

• Length: 426 bp

>T89919 NZ_CP025228:c3537988-3537563 [Actinomyces qiguomingii]
GTGAACGGAACTACGCGCATAGCCGTCGATACGAGTGTTGCCATTCCTCTGCTGGTAGCCTCCCATGAGGCGCACCGCCC
GGTGCGTGACTGGGCGAGGGGGAGGCGGCTGAGCCTCAGTGGACACGCCCTGGCGGAGACTTATGCGGTGCTGACGCGGT
TGCCCGCAGACGCGCGCGTGTCCGCCGAAGACGCGGTCGCGCTTATTGACGACCGTTTCCCGGAGGTGCTCGCCCTTTCT
GCGAATTCGGCGATCACGGCGCACCGGCGATTGGCCAGCCTTGGAATCGCAGGCGGTGCCGTCTACGACGGTCTGGTCGC
CCTTGCGGCACTGGAGAATGGCGCATTGCTCGCCACCAGGGACGCACGCACAAGGGACACATATGAGGCGGTGGGAGTCG
CCGTCGAGGTAGTCGCGGCCGGATAG

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 8331.56 Da
• Isoelectric Point: 6.2542

>AT89919 WP_103061620.1 NZ_CP025228:c3538224-3537985 [Actinomyces qiguomingii]
MEVTIDSGGRILLPKRLRESLGLLPGTKVDVSPYGAGVQVIPGGRAARVVRDEDGNLVATSQTPVTDDVMFALIDGGRR

Nucleotide

• Length: 240 bp

>AT89919 NZ_CP025228:c3538224-3537985 [Actinomyces qiguomingii]
ATGGAGGTGACGATTGATTCGGGCGGCCGCATCCTCCTGCCGAAGCGACTGCGGGAGTCGCTTGGATTGCTGCCGGGTAC
GAAGGTCGATGTGTCTCCCTATGGTGCCGGCGTGCAAGTGATTCCGGGGGGGCGTGCCGCACGGGTGGTGCGCGATGAGG
ACGGGAACCTGGTCGCCACTTCGCAGACCCCAGTAACCGATGACGTGATGTTTGCACTGATCGATGGTGGCAGAAGGTGA