Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PemK-RelB
Location 2996084..2996648 Replicon chromosome
Accession NZ_CP025228
Organism Actinomyces qiguomingii strain actinomyces sp. 410

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag CWT10_RS12625 Protein ID WP_103062372.1
Coordinates 2996084..2996416 (-) Length 111 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag CWT10_RS12630 Protein ID WP_103062371.1
Coordinates 2996403..2996648 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CWT10_RS12600 2991209..2991736 - 528 WP_103061808.1 GNAT family N-acetyltransferase -
CWT10_RS12605 2991783..2992651 - 869 Protein_2474 Fic family protein -
CWT10_RS12610 2992726..2993724 - 999 WP_103061807.1 glutamine-hydrolyzing GMP synthase -
CWT10_RS12615 2994060..2994284 - 225 WP_158247579.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
CWT10_RS12620 2994514..2995824 - 1311 WP_103062545.1 ISL3 family transposase -
CWT10_RS12625 2996084..2996416 - 333 WP_103062372.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
CWT10_RS12630 2996403..2996648 - 246 WP_103062371.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
CWT10_RS12635 2996745..2998391 - 1647 WP_103062370.1 glutamine-hydrolyzing GMP synthase -
CWT10_RS12640 2998437..2999174 - 738 WP_103062369.1 sulfite exporter TauE/SafE family protein -
CWT10_RS12645 2999361..3000557 + 1197 WP_103062368.1 Gfo/Idh/MocA family oxidoreductase -
CWT10_RS12650 3000617..3001543 + 927 WP_103062367.1 myo-inosose-2 dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-106)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-58)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 12014.81 Da        Isoelectric Point: 6.3095

>T89918 WP_103062372.1 NZ_CP025228:c2996416-2996084 [Actinomyces qiguomingii]
MRRGEVWTLRNDAYASKARSVVVVQSDELTGFGSVVLCLFTSFDSRDIPTRVPIDPSEGNGLAKPSYVMTEKIVTVDKQL
LGKRVGILDKDDMAEVSRQLIAVLGLQASS

Download         Length: 333 bp

>T89918 NZ_CP025228:c2996416-2996084 [Actinomyces qiguomingii]
ATGAGGCGCGGTGAGGTTTGGACGCTGCGGAACGACGCCTATGCGAGCAAGGCGCGATCGGTAGTTGTCGTGCAGAGCGA
TGAACTGACAGGCTTCGGATCGGTTGTCCTGTGCCTATTCACGAGCTTCGACTCGCGCGACATCCCCACGAGGGTCCCTA
TCGACCCGAGTGAAGGTAACGGGCTTGCGAAACCGAGCTACGTGATGACCGAGAAGATCGTCACTGTGGACAAACAACTT
CTCGGAAAGCGAGTTGGTATCCTGGACAAAGATGACATGGCAGAGGTCTCGCGGCAGCTCATCGCCGTCCTAGGGTTGCA
GGCATCAAGCTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9196.32 Da        Isoelectric Point: 4.8096

>AT89918 WP_103062371.1 NZ_CP025228:c2996648-2996403 [Actinomyces qiguomingii]
MAMRQIATRVDAEQAELFKETTRKLGTTPADALRMFVTAFNSHRGFPYDVRLSEDVEPFATEEDATRFATDLSLRAINEA
R

Download         Length: 246 bp

>AT89918 NZ_CP025228:c2996648-2996403 [Actinomyces qiguomingii]
ATGGCAATGAGACAGATAGCCACGAGGGTTGACGCGGAGCAGGCGGAGCTCTTCAAGGAGACCACGAGGAAGCTCGGCAC
CACCCCGGCGGACGCGCTGCGCATGTTCGTGACCGCCTTCAACAGTCACCGTGGCTTCCCTTACGACGTGCGCCTCTCGG
AGGACGTCGAGCCGTTCGCCACCGAGGAGGACGCCACCAGGTTTGCGACGGACCTGTCCCTGAGGGCGATCAATGAGGCG
CGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References