Detailed information of TA system TA089917

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YoeB-YefM
• Location: 1168548..1169090
• Replicon: chromosome
• Accession: NZ_CP025228
• Organism: Actinomyces qiguomingii strain actinomyces sp. 410

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: CWT10_RS04765
• Protein ID: WP_103063513.1
• Coordinates: 1168836..1169090 (+)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: CWT10_RS04760
• Protein ID: WP_103063512.1
• Coordinates: 1168548..1168799 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CWT10_RS04745	1163774..1163965	-	192	WP_073327266.1	50S ribosomal protein L28	-
CWT10_RS04750	1164249..1166069	+	1821	WP_103063511.1	DAK2 domain-containing protein	-
CWT10_RS04755	1166147..1168396	+	2250	WP_103063568.1	ATP-dependent DNA helicase RecG	-
CWT10_RS04760	1168548..1168799	+	252	WP_103063512.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
CWT10_RS04765	1168836..1169090	+	255	WP_103063513.1	Txe/YoeB family addiction module toxin	Toxin
CWT10_RS04770	1169164..1169784	-	621	WP_103063514.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
CWT10_RS04775	1170301..1173801	+	3501	WP_103063515.1	beta-galactosidase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (2-70)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 9868.28 Da
• Isoelectric Point: 8.0092

>T89917 WP_103063513.1 NZ_CP025228:1168836-1169090 [Actinomyces qiguomingii]
MRLVWDSSAWEDYCYWQTADRRTLKRINTLIAAALREPFAGIGKPEPLKYGAPGAWSRRITEEHRLVYLVDGEDLVILQA
RYHY

Nucleotide

• Length: 255 bp

>T89917 NZ_CP025228:1168836-1169090 [Actinomyces qiguomingii]
ATGAGACTTGTCTGGGACTCCTCCGCCTGGGAGGACTACTGCTACTGGCAGACGGCCGACCGGCGCACGCTAAAACGCAT
CAACACACTCATCGCCGCCGCCCTGCGTGAACCCTTCGCCGGCATCGGCAAACCGGAACCGCTCAAGTACGGGGCTCCCG
GCGCCTGGTCCCGGCGCATCACCGAGGAGCATCGACTGGTCTACTTGGTGGACGGCGAGGACCTGGTCATCCTGCAGGCC
CGCTACCACTACTGA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9495.50 Da
• Isoelectric Point: 4.6652

>AT89917 WP_103063512.1 NZ_CP025228:1168548-1168799 [Actinomyces qiguomingii]
MSISATEARRTLFPLIERVNADRDAVEIVSRHGNAVLMSADEYSAWQETAYLFRSPENARRLLDSYERARAGRVEAHELD
LDD

Nucleotide

• Length: 252 bp

>AT89917 NZ_CP025228:1168548-1168799 [Actinomyces qiguomingii]
ATGTCGATCAGCGCAACCGAGGCGCGGCGCACCCTGTTCCCGCTGATCGAGCGAGTCAACGCGGACCGGGACGCCGTCGA
GATCGTCTCCCGCCACGGCAACGCCGTGCTCATGTCCGCCGACGAGTACTCGGCCTGGCAGGAGACGGCCTATCTCTTCC
GTTCACCCGAGAATGCCCGGCGCCTGCTGGACTCCTACGAGCGCGCCCGCGCAGGACGGGTCGAGGCCCACGAACTCGAC
CTCGACGACTGA