Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 1036818..1037347 Replicon chromosome
Accession NZ_CP025228
Organism Actinomyces qiguomingii strain actinomyces sp. 410

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag CWT10_RS04215 Protein ID WP_103063423.1
Coordinates 1037057..1037347 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID -
Locus tag CWT10_RS04210 Protein ID WP_103063422.1
Coordinates 1036818..1037060 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CWT10_RS04180 1032139..1032948 + 810 WP_158247662.1 PH domain-containing protein -
CWT10_RS04185 1033191..1033394 + 204 WP_103063417.1 GyrI-like domain-containing protein -
CWT10_RS04190 1033994..1034731 + 738 WP_103063418.1 hypothetical protein -
CWT10_RS04195 1034876..1035310 + 435 WP_103063419.1 GNAT family N-acetyltransferase -
CWT10_RS04200 1035352..1035792 - 441 WP_103063420.1 aminoacyl-tRNA hydrolase -
CWT10_RS04205 1035826..1036752 + 927 WP_128683284.1 hypothetical protein -
CWT10_RS04210 1036818..1037060 + 243 WP_103063422.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
CWT10_RS04215 1037057..1037347 + 291 WP_103063423.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CWT10_RS04220 1037369..1037929 - 561 WP_103063424.1 DUF4256 domain-containing protein -
CWT10_RS04225 1038069..1039040 + 972 WP_103063425.1 diaminopimelate dehydrogenase -
CWT10_RS04230 1039202..1039822 + 621 WP_103063426.1 alpha/beta hydrolase -
CWT10_RS04235 1040830..1041705 + 876 WP_103063428.1 DUF5131 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin

Antitoxin ParD

(1-77)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11187.73 Da        Isoelectric Point: 8.4857

>T89916 WP_103063423.1 NZ_CP025228:1037057-1037347 [Actinomyces qiguomingii]
MSIYRLTPAARRDLSAIWDYTEERWGPLQAETYVRKLQAGLERLADDPRRGHARDEVRPGFLSYPVGRHVIFYMEQADGV
DVIRVLPQRVDPARHL

Download         Length: 291 bp

>T89916 NZ_CP025228:1037057-1037347 [Actinomyces qiguomingii]
ATGAGCATCTATCGGCTGACCCCGGCGGCGCGTCGCGACCTGTCGGCGATCTGGGATTACACCGAAGAGCGGTGGGGACC
GTTGCAGGCCGAGACGTATGTGCGTAAGTTGCAGGCAGGGCTGGAACGTCTAGCAGATGATCCGCGCCGGGGGCATGCTC
GTGATGAGGTGCGTCCCGGGTTCCTGAGCTACCCGGTCGGACGCCATGTCATCTTTTATATGGAACAGGCGGACGGCGTC
GACGTCATCCGTGTCCTCCCTCAACGCGTGGATCCTGCCAGGCATCTGTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8559.44 Da        Isoelectric Point: 4.5659

>AT89916 WP_103063422.1 NZ_CP025228:1036818-1037060 [Actinomyces qiguomingii]
MATNTSVSLDDHFTGFIAHQVGSGRYRSASEVVRAGLRLLEDRETELAALREALAEGEASGPAEPFDFDAFIAAKTSKTT

Download         Length: 243 bp

>AT89916 NZ_CP025228:1036818-1037060 [Actinomyces qiguomingii]
ATGGCAACGAATACCTCCGTCAGCCTCGACGATCACTTCACCGGATTCATTGCGCACCAGGTCGGATCTGGACGTTACCG
GTCCGCAAGCGAGGTCGTCCGCGCTGGCCTGCGCCTGTTGGAGGACCGGGAGACGGAACTGGCGGCGTTACGTGAAGCGC
TTGCGGAAGGCGAGGCGAGTGGTCCTGCTGAGCCCTTCGACTTCGATGCCTTCATCGCCGCCAAAACCTCAAAGACGACA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References