Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/YoeB-RelB
Location 2425002..2425524 Replicon chromosome
Accession NZ_CP025227
Organism Actinomyces wuliandei strain 299

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag CWS50_RS10040 Protein ID WP_127842683.1
Coordinates 2425261..2425524 (+) Length 88 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag CWS50_RS10035 Protein ID WP_127842682.1
Coordinates 2425002..2425259 (+) Length 86 a.a.

Genomic Context

CWS50_RS10035CWS50_RS10040CWS50_RS10025CWS50_RS10030CWS50_RS10045CWS50_RS10050CWS50_RS10055CWS50_RS10060
Location: 2425002..2425259 (258 bp)
Type: Antitoxin
Protein ID: WP_127842682.1
Location: 2425261..2425524 (264 bp)
Type: Toxin
Protein ID: WP_127842683.1
Location: 2420826..2421926 (1101 bp)
Type: Others
Protein ID: WP_127842680.1
Location: 2422004..2424712 (2709 bp)
Type: Others
Protein ID: WP_127842681.1
Location: 2425567..2426145 (579 bp)
Type: Others
Protein ID: WP_127842684.1
Location: 2426135..2426929 (795 bp)
Type: Others
Protein ID: WP_127842685.1
Location: 2426884..2427270 (387 bp)
Type: Others
Protein ID: WP_127842686.1
Location: 2427394..2428473 (1080 bp)
Type: Others
Protein ID: WP_127842687.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
CWS50_RS100252420826..2421926-1101WP_127842680.1AAA family ATPase-
CWS50_RS100302422004..2424712-2709WP_127842681.1pyruvate, phosphate dikinase-
CWS50_RS100352425002..2425259+258WP_127842682.1type II toxin-antitoxin system prevent-host-death family antitoxinAntitoxin
CWS50_RS100402425261..2425524+264WP_127842683.1Txe/YoeB family addiction module toxinToxin
CWS50_RS100452425567..2426145-579WP_127842684.1hypothetical protein-
CWS50_RS100502426135..2426929-795WP_127842685.1hypothetical protein-
CWS50_RS100552426884..2427270-387WP_127842686.1hypothetical protein-
CWS50_RS100602427394..2428473-1080WP_127842687.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10737.02 Da        Isoelectric Point: 9.4176

>T89914 WP_127842683.1 NZ_CP025227:2425261-2425524 [Actinomyces wuliandei]
MAVAWDNDAWEDYLWWQKQDRKTLRRINQLLRDIQRDATTGTGRPEPLRYNLAGYWSRRITSEHRLVYRVDERGDIHVLS
CRYHYER

Download         Length: 264 bp

>T89914 NZ_CP025227:2425261-2425524 [Actinomyces wuliandei]
ATGGCGGTCGCATGGGACAACGACGCCTGGGAGGACTACCTCTGGTGGCAGAAGCAGGACCGTAAGACCCTCAGACGCAT
CAACCAGCTCCTCCGCGACATCCAGCGCGACGCGACCACCGGGACCGGCAGACCCGAGCCCCTGCGCTACAACCTGGCCG
GGTACTGGTCGCGCCGCATCACCAGCGAGCACCGCCTTGTCTACCGTGTGGACGAGCGAGGAGACATCCACGTGCTCTCA
TGCCGGTACCACTACGAGCGCTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9593.70 Da        Isoelectric Point: 4.4901

>AT89914 WP_127842682.1 NZ_CP025227:2425002-2425259 [Actinomyces wuliandei]
MRTMTYTESRARYAEVLDSVVNDCEEVVITRAGHEPAVIVSLAEYQSLKETDYLLRNPANARHLINAIARSEAGQDAYHD
LIEVE

Download         Length: 258 bp

>AT89914 NZ_CP025227:2425002-2425259 [Actinomyces wuliandei]
ATGAGGACCATGACCTACACCGAATCGCGCGCCCGCTACGCCGAGGTCCTTGACTCCGTGGTCAACGACTGCGAGGAGGT
CGTCATCACCCGAGCAGGCCACGAGCCCGCCGTCATCGTCTCCCTGGCCGAGTACCAGTCCCTCAAGGAGACCGACTACC
TCCTGCGCAACCCGGCCAACGCCCGGCACCTGATCAACGCGATCGCGCGCTCCGAGGCCGGGCAGGACGCCTACCACGAC
CTCATTGAGGTCGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
No matching records found

References