Detailed information of TA system TA089911

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 4165148..4165664
• Replicon: chromosome
• Accession: NZ_CP025225
• Organism: Enterobacter cancerogenus strain CR-Eb1

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: CWI88_RS19745
• Protein ID: WP_101738342.1
• Coordinates: 4165148..4165432 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: D2ZLS4
• Locus tag: CWI88_RS19750
• Protein ID: WP_006179065.1
• Coordinates: 4165422..4165664 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CWI88_RS19730	4161460..4162032	+	573	WP_101738340.1	PTS sugar transporter subunit IIA	-
CWI88_RS19735	4162400..4164538	+	2139	WP_088208738.1	anaerobic ribonucleoside-triphosphate reductase	-
CWI88_RS19740	4164680..4165144	+	465	WP_101738341.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
CWI88_RS19745	4165148..4165432	-	285	WP_101738342.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
CWI88_RS19750	4165422..4165664	-	243	WP_006179065.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
CWI88_RS19755	4165742..4167652	-	1911	WP_101738343.1	BglG family transcription antiterminator	-
CWI88_RS19760	4167672..4168808	-	1137	WP_101738344.1	lactonase family protein	-
CWI88_RS19765	4168922..4169662	-	741	WP_088208734.1	KDGP aldolase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-83)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-65)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 10831.73 Da
• Isoelectric Point: 10.1749

>T89911 WP_101738342.1 NZ_CP025225:c4165432-4165148 [Enterobacter cancerogenus]
MTYELEFDPRALKEWRKLGDTVKAQFKKKLPSVLVNPRNESARLHDLPDCYKIKLKSSVYCLVYQVQDAVVIVFVISIGK
REKSAAYQAASKRL

Nucleotide

• Length: 285 bp

>T89911 NZ_CP025225:c4165432-4165148 [Enterobacter cancerogenus]
ATGACTTATGAACTGGAATTCGACCCGAGGGCATTAAAGGAGTGGCGTAAACTGGGCGATACCGTGAAAGCCCAGTTTAA
GAAGAAGTTACCCAGCGTACTGGTGAATCCCCGGAATGAATCTGCCCGCCTGCATGACCTGCCTGACTGCTACAAGATAA
AGCTTAAATCCTCTGTCTACTGCCTGGTTTATCAGGTGCAGGACGCGGTGGTTATTGTTTTTGTCATTTCCATCGGTAAG
CGAGAGAAATCCGCTGCGTATCAGGCCGCGAGCAAACGGCTTTAG

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8956.37 Da
• Isoelectric Point: 5.0807

>AT89911 WP_006179065.1 NZ_CP025225:c4165664-4165422 [Enterobacter cancerogenus]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTISDGEEALIQTVRERLANPQKGIKVSLDDL

Nucleotide

• Length: 243 bp

>AT89911 NZ_CP025225:c4165664-4165422 [Enterobacter cancerogenus]
ATGGCCACGCTGAACGTCCGTCTGGATGACAAACTTAAAAACGAGGCGTATGCCGTGCTGGAAAAACTCAATATCACCCC
CACTGAAGCGGTACGGCTACTCTTTCAGTACGTTGCAGAGACCGGACGGATGCCGGTGAAAACTGTCACCATAAGCGACG
GTGAAGAGGCGCTTATTCAGACAGTCCGGGAGCGACTGGCTAATCCACAAAAGGGAATTAAGGTTAGTCTGGATGACTTA
TGA

Structures

Antitoxin

• AlphaFold DB: D2ZLS4